Filtyp
Objectives: The antiinflammatory effect of macrolide antibiotics has been well-established, as has their role in the treatment of certain disorders of chronic airway inflammation. Several studies have suggested that long-term, low-dose macrolides may be efficacious in the treatment of chronic rhinosinusitis; however, these studies have lacked a control group. To date, this effect has not been test
Ring preparations of the superficial buccal segment of the human facial vein, taken from extirpated tissue in 12 patients during neck surgery, were studied in vitro. The vein developed a maintained intrinsic myogenic tone in response to passive stretch and was supplied with alpha- as well as beta-adrenoceptors, both of which could be influenced by transmural nerve stimulation (TNS) and noradrenali
Popular Abstract in Swedish Astma är en folksjukdom. Uppemot 10 % av befolkningen i Sverige har mer eller mindre uttalade symptom. Barn är ofta värst drabbade. Vid astma drar luftrören ihop sig så att det blir svårt att andas. Detta tillstånd kan vara livshotande. Tack vare lång tids intensiv luftvägsforskning är en del mekanismer i sjukdomsförloppet kartlagda. Till exempel karakteriseras bronksleEosinophils, containing tissue toxic granule proteins, are regarded a culprit cell in asthma pathogenesis. Using animal and human experimental models of asthma effects on eosinophilic airway inflammation were investigated in vivo. The current research paradigm regarding spontaneous and steroid-induced clearance of airway tissue eosinophils exclusively involves death through apoptosis followed by p
We studied the A-band photodissociation of bromoiodomethane, CH2BrI, in acetonitrile solution at room temperature by femtosecond pump-probe spectroscopy, Initiated by the 266 nm light, this reaction leads to the CH2Br-I isomer, most likely produced via in-cage recombination of the CH,Br and I photofragments. The isomer is formed vibrationally excited with a time constant of similar to7.5 ps and th
his study investigated how 60 teachers' in Swedish nurse education, in higher education, understood and taught internationalization. The teachers answered a self-administered questionnaire. A phenomenographic, contextual and content analysis approach was used. The results show that teachers were found to experience and understand internationalization in different ways, which could be related to tw
Attachment of microorganisms to host cells is believed to be a critical early step in microbial pathogenesis. The aim of the study was to determine the role of the known glycosaminoglycan (GAG) binding activity of Staphylococcus aureus and coagulase-negative staphylococci (CoNS) in their attachment to six different eukaryotic cell lines. Three staphylococcal species expressing GAG binding capacity
AIM: To study the cellular transport of L68Q cystatin C, the cystatin variant causing amyloidosis and brain haemorrhage in patients suffering from hereditary cystatin C amyloid angiopathy (HCCAA). METHODS: Expression vectors for wild-type and L68Q cystatin C were constructed and used to transfect mouse NIH/3T3 cells. Stable cell clones were isolated after cotransfection with pSV2neo. Clones expres
Background: Serial Analysis of Gene Expression (SAGE) is a functional genomic technique that quantitatively analyzes the cellular transcriptome. The analysis of SAGE libraries relies on the identification of ditags from sequencing files; however, the software used to examine SAGE libraries cannot distinguish between authentic versus false ditags ("quasi-ditags"). Results: We provide examples of qu
Popular Abstract in Swedish I början av 1990-talet accepterade Vägverket metoden att mäta nyttan av trafiksäkerhet utifrån skattning av enskilda individers betalningsvilja för riskreduktion. Sedan dess har det diskuterats hur man ska gå tillväga för att finna den mest tillförlitliga metoden för att empiriskt mäta individernas betalningsvilja. Syftet med denna avhandling är att beskriva och analyseAt the beginning of the 1990s the Swedish National Road Administration (SNRA) adopted the willingness to pay (WTP) approach for estimating the benefits of safety improvements. However, since then there have been discussions about how to find the most valid and reliable empirical methods to conduct WTP studies. The purpose of this thesis is to describe and analyze approaches used to estimate the va
Effects on physical workload were quantified when introducing new information technology in air traffic control. Seven female and 7 male air traffic controllers were studied in an old control system, and during simulated-but similar-work in a new, mouse-based system. Postures, movements and muscular load were recorded (inclinometry for head, neck, back and upper arms; goniometry for wrists; elect
The effect of kinship on growth and use of space by individually PIT-tagged 1+ brown trout was studied for 11 weeks in eight stream enclosures. Each enclosure consisted of two sections, separated by a region containing PIT-detecting antennae, which enabled us to measure use of sections by all individuals. Two types of sibling groups were tested, a single sibling group, F1, consisting of four indiv
BACKGROUND: The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive glomerulonephritis, with or without lung hemorrhage, whereas autoantibodies spe
Neuronal ceroid lipofuscinoses (NCLs) represent a large group of inherited neurodegenerative disorders characterized by an abnormal accumulation of lipopigment in neuronal and extraneuronal cells. The authors present a case of juvenile neuronal ceroid lipofuscinosis in a 7-year-old boy. Ultrastructural examination of a skin biopsy disclosed deposits of curvilinear profiles and fingerprint-like str
The main focus in this licentiate thesis is a description of the environmentally introduced action of diffusing and chemically reactive (e.g. carbonation and chemical-physical adsorption-desorption) matter in the pore solution and in the air-filled space in the pore system of the material. The governing equations describing the variation of concentrations of different substances and temperature wi
A diagnosis-antibiotic prescribing study was performed in 5 counties in Sweden during 1week in November in the y 2000 and 2002, respectively. As part of the study, the characteristics and clinical management of patients who received diagnoses of urinary tract infections (UTIs) ( n = 1564) in primary care, were analysed. 85% of the visits were by women, and 74% of all consultations were diagnosed a
