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E. coli continues to be a popular host organism for production of recombinant proteins. To obtain a high volumetric productivity at the cultivation stage, it is important to achieve a high cell density and a high specific productivity per cell. In many fed-batch processes, the substrate feed rate eventually becomes limited by the oxygen transfer capacity of the bioreactor. While biomass can contin
Bangladesh has made significant progress in health indicators in recent years in spite of her low level of income. This is mainly due to the commitment of the state supported by donors in providing preventive care with respect to child health and family planning. However, there are serious problems related to both access and quality of curative care that hurt the poor most. Infrastructures for ser
This thesis, which is based on four original papers, deals with human dendritic cells (DCs) in immunity and allergy. DCs play a key role in the regulation of immune responses by acting as the sentinels of the immune system, specialized in the uptake of a diverse range of antigens. These cells migrate to local lymph nodes and become highly efficient in inducing T cell proliferation, thus inducing a
A method for the inversion of wavefield spectra in non-destructive testing of pavements is outlined. Data acquisition and processing is based on the Multichannel Analysis of Surface Waves (MASW) method. The inversion of a vertical-shear wave velocity profile is conducted on the full wave field spectrum using the Fast Simulated Annealing (FSA) algorithm. This procedure avoids dealing with discrete
Within the framework of the Swedish national trial with Intelligent Speed Adaptation (ISA) in urban areas, the effects of large scale use of “active accelerator” were evaluated. 284 cars were equipped with the system for a period of 5-11 months in the city of Lund. The driving data of all equipped vehicles were logged with regard to time and speed, both before and after activating the system. Driv
NGC 595 is, after NGC 604, the second most luminous HII region in theMilky Ways neighbouring spiral galaxy M 33. Its Wolf-Rayet starcontent has mainly been unveiled by two different channels. On the onehand, the stellar population of NGC 595 has been resolved and its WRstars identified through on-line/off-line HeIIlambda4686 observationsrealised with the HST. Nevertheless, due to the limited numbe
The distribution of exogeneous radiolabelled surfactant was investigated in immature newborn lambs who were either ventilated vigorously at birth, and then given surfactant, or who were given surfactant before the first breath. Surfactant distribution was more uniform, and lung mechanics better among the latter.
In 1949, Swedish actress Ingrid Bergman caused a well known scandal in Hollywood by leaving her Swedish husband Petter Lindström and their daughter for Italian film director Roberto Rossellini. The effects of this scandal in America have been thoroughly described in works like Bergman’s autobiography (Bergman, 1980), Donald Spoto’s recent biography on Bergman (Spoto, 1997) and in specialized schol
Popular Abstract in Swedish Målet med avhandlingen är en ökad kostnadseffektivitet i förebyggande behandling av blödarsjuka. Allmän bakgrund om blödarsjuka och förebyggande behandling Blödarsjuka är en ärftlig sjukdom som endast uppträder hos män, även om anlaget överförs av kvinnliga bärare. I Sverige finns ungefär 700 blödarsjuka. Sjukdomen tar sig uttryck i en abnorm blödningsbenägenhet med fThe aim of the thesis was to increase cost-effectiveness in prophylactic treatment of haemophilia. Prophylaxis is effective to prevent bleedings and arthropathy, but the high cost limits its use. First, a new distribution system for clotting factor concentrates was implemented in Sweden to improve availability and reduce risks and costs. Next, optimization of dosing in prophylactic treatment was e
This study aims to determine the potential origin of Olea pollen recorded in Badajoz in the Southwest of the Iberian Peninsula during 2009-2011. This was achieved using a combination of daily average and diurnal (hourly) airborne Olea pollen counts recorded at Badajoz (south-western Spain) and A parts per thousand vora (south-eastern Portugal), an inventory of olive groves in the studied area and
The timing of the ice margin retreat of the Late Glacial Patagonian Ice Sheet (PIS) in southern Patagonia has been the object of discussion for many years. In order to resolve questions about the complex response of the PIS to past climate change, any geological interpretation and data modelling need evaluation against an absolute chronology. The aim of this project is to investigate the applicabi
We report on the observation of the bright, long gamma-ray burst, GRB 090926A, by the Gamma-ray Burst Monitor and Large Area Telescope (LAT) instruments on board the Fermi Gamma-ray Space Telescope. GRB 090926A shares several features with other bright LAT bursts. In particular, it clearly shows a short spike in the light curve that is present in all detectors that see the burst, and this in turn
The calcium-dependent transcription factor NFAT was first described as a key player in immune cell regulation. Since then, NFAT signaling has been shown to be crucial for normal vascular development during embryogenesis. This pathway is also an important regulator of cell growth and differentiation in various cell types, however, the functional significance of NFAT in the vasculature is largely un
