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Background and Purpose- In ischemic stroke, breakdown of the blood-brain barrier (BBB) aggravates brain damage. Pericyte detachment contributes to BBB disruption and neurovascular dysfunction, but little is known about its regulation in stroke. Here, we investigated how loss of RGS5 (regulator of G protein signaling 5) in pericytes affects BBB breakdown in stroke and its consequences. Method- We u
BackgroundComplex clusters of rearrangements are a challenge in interpretation of cancer genomes. Some clusters of rearrangements demarcate clear amplifications of driver oncogenes but others are less well understood. A detailed analysis of rearrangements within these complex clusters could reveal new insights into selection and underlying mutational mechanisms.Patients and methodsHere, we systema
The streaming instability is a promising mechanism to drive the formation of planetesimals in protoplanetary disks. To trigger this process, it has been argued that sedimentation of solids onto the mid-plane needs to be efficient, and therefore that a quiescent gaseous environment is required. It is often suggested that dead-zone or disk-wind structure created by non-ideal magnetohydrodynamical (M
All competition analysis, including in relation to mergers, begins by defining the relevant market. In sectors where innovation plays a major role, the definition of the relevant market must also take into account the R&D efforts of the merging firms. One field in which R&D poles can be identified early on is the pharmaceutical sector. In March 2015, the European Commission released the pu
It has been discussed how important the contributions of informal investors in supporting entrepreneurs and developing startups. The market for informal venture capital is almost invisible source of financing for entrepreneurial ventures, which can explain the difficulty of finding these investors. However, what if the entrepreneur were able to find virgin angel, private individuals who want to un
The now redlisted P. vulgaris has continuously declined throughout its distribution range. In this project, 72 localities in eastern Scania, southern-most Sweden, were investigated, 19 of them contained viable populations of P. vulgaris and in the remaining 53 it had gone extinct. The localities were assessed as to why the extinction had occurred, and if the locality still appeared to be suitable
This paper explores social science students’ generalized trust (trust towards most people in a particular nation). The analyses are based on the survey data collected at nine universities in Tbilisi, Georgia. This study presents evidence that trust towards the people that the students meet for the first time is the strongest plausible factor behind their generalized trust level, followed by trust
Purpose: The main purpose is to see if dividend smoothing is a pertinent phenomenon among Swedish public firms. The study also aims to identify what firm characteristics that drive dividend smoothing. Theoretical Framework: The theoretical framework covers different explanations of dividend smoothing behavior, such as information asymmetries, agency issues and investor clientele motivations. Also
In this study, possibilities to belong in the contemporary Chinese society are recognized to differences along axes of sexual orientation. Lesbians and gays in the LGBT group are exposed to violations of their human rights in forms of discrimination and lack of legal protection. The aim of this thesis is to critically explore “politics of belonging” by highlighting processes of inclusion and exclu
Marketing research has acknowledged the concept of authenticity. It is argued that consumers in modern society increasingly search for something real, in contrast to what they perceive as mediated and distorted. Producers of regional food brands has acknowledged this trend, and started to market their products as being authentic. Given the potential practical and theoretical contributions in study
Abstract The unprecedented fast-changing environment, embracing new information, manufacturing and process technologies in the context of the increasing globalisation of product and service market has had significant effect on the nature of work and subsequently affected career management of employees. Organizations today embark on many changes internally and externally in order to strengthen ther
Intestinal mononuclear phagocytes, comprising macrophages (MΦs) and dendritic cells (DCs), play important roles in the generation and the regulation of immune responses to intestinal antigens, and alterations in the development and/or the function of these cells are thought to contribute to the pathogenesis of inflammatory bowel disease. In this review, we discuss the role of tumor necrosis factor
The treatment of immune thrombocytopenic purpura (ITP) in children is controversial, requiring individualized assessment of the patient and consideration of treatment options. If the platelet count is >10 000/μL and the patient is asymptomatic, a 'watch and wait' strategy is appropriate since most children with ITP will recover completely without pharmacotherapy. If therapy is indicated because of
Charge transfer states in blends of organic semiconductors have significant importance for the functioning of organic optoelectronic devices, but are also interesting from the perspective of fundamental research as many of their properties as well as their influence on the photophysics of the material are not yet completely understood. We report on a time-resolved photoluminescence study of the ph
Presently, the mountain gorilla in Rwanda, Uganda, and the Democratic Republic of Congo is endangered mainly by poaching and habitat loss. This paper sets out to investigate the possible resolution of poaching involving the local community by using benefit sharing schemes with local communities. Using a bioeconomic model, the paper demonstrates that the current revenue sharing scheme yields subopt
Plasma proteins occur in the airway lumen in inflammatory airway diseases. This study tests the hypothesis that airway microvascular-epithelial exudation of plasma proteins, as induced by a non-injurious inflammatory mediator, is characterized by loss of size-selectivity. Using a nasal pool-device, the nasal mucosa of 10 allergic individuals, without current disease, was sequentially exposed to sa
