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Background: Inherited platelet disorders (IPDs) are rare diseases characterized by reduced blood platelet counts and/or impaired platelet function. Recognizing IPDs is advisable but often challenging. The diagnostic tools include clinical evaluation, platelet function tests, and molecular analyses. Demonstration of a pathogenic genetic variant confirms IPDs. We established a method to assess the p
Selection leading to adaptation to interactions may generate rapid evolutionary feedbacks and drive diversification of species interactions. The challenge is to understand how the many traits of interacting species combine to shape local adaptation in ways directly or indirectly resulting in diversification. We used the well-studied interactions between Lithophragma plants (Saxifragaceae) and Grey
Basic and translational research needs rapid methods to test antimicrobial formulations. Bioluminescent bacteria and advanced imaging systems capable of acquiring bioluminescence enable us to quickly and longitudinally evaluate the efficacy of antimicrobials. Conventional approaches, such as radial diffusion and viable count assays, are time-consuming and do not allow for longitudinal analysis. Bi
Bacteria in the order 'Candidatus Brocadiales' within the phylum Planctomycetes (Planctomycetota) have the remarkable ability to perform anaerobic ammonium oxidation (anammox). Two families of anammox bacteria with different biogeographical distributions have been reported, marine Ca. Scalinduaceae and freshwater Ca. Brocadiaceae. Here we report evidence of three new species within a novel genus a
The theoretical foundation of inflation targeting was laid out by the Swedish economist Knut Wicksell (1851-1926) in his groundbreaking treatise, Interest and Prices, published originally in German in 1898. Here he proposed price stability as the rule for monetary policy. Today, inflation targeting is considered the best-practice approach to monetary policy across the world. It has contributed to
Climbing fibers, which originate in the inferior olive and project to Purkinje cells and Golgi cells in the cerebellar cortex, were activated at low (0.4-Hz) and high (4-Hz) frequencies by peri-orbital stimulation in decerebrate ferrets. Climbing fiber responses were recorded as field potentials from the c3 zone of the cerebellar surface. When periorbital stimulation was applied at high frequency,
In 1969, a government report concluded that there was a need for closer contact between the citizens and Swedish government agencies. Television, at this time still considered a new medium, was highlighted in the report as a valuable form of mass communication with great yet unfulfilled promise as a disseminator of government information. A heated debate about the role and function of government i
Characterizing the diversity and structure of host-parasite communities is crucial to understanding their eco-evolutionary dynamics. Malaria and related haemosporidian parasites are responsible for fitness loss and mortality in bird species worldwide. However, despite exhibiting the greatest ornithological biodiversity, avian haemosporidians from Neotropical regions are quite unexplored. Here, we
This article analyses Swedish social workers’ accounts of custody when a parent is in remand prison or prison due to homicidal violence that has resulted in the death of the other parent. How do social workers justify or excuse assessments of custody and custody transfers? What legal dilemmas can be discerned? The empirical material comprises six group interviews with 14 Swedish social workers bas
The microphysical quasi-equilibrium in an ascending adiabatic parcel is elucidated by an analytical theory in 0D with drastic simplifications. The theory predicts how in-cloud activation is most likely to be triggered by the onset of precipitation during sufficient ascent, with the ascent only needing to approach almost twice the cloud-base updraft speed aloft. The precipitation and cloud condensa
Most plants form symbiotic associations with arbuscular mycorrhizal fungi (AMF). AMF increase the uptake of plant nutrients by extending their extra-radical mycelium (ERM) in the soil where other groups of microorganisms may suppress the activity of the ERM. However, little is known about such suppression in natural soils. This work aimed to investigate the incidence of AMF suppression among soils
Currently, there is a need for diagnostic markers in Lewy body disorders (LBD). α-synuclein (αSyn) RT-QuIC has emerged as a promising assay to detect misfolded αSyn in clinically or neuropathologically established patients with various synucleinopathies. In this study, αSyn RT-QuIC was used to analyze lumbar CSF in a clinical cohort from the Swedish BioFINDER study and postmortem ventricular CSF i
When it comes to the field of drug studies, researchers have tended to privilege men’s perspectives and experiences, assuming women to be mostly marginal, as primarily victims and accomplices. Further, when women’s experiences are taken into account, a view of them as only women has tended to be pushed to the forefront. As such, we are sorely lacking research departing from women’s own recollectio
This master thesis explores the mechanisms and optimization strategies of a pneumatic conveying system. By investigating the impact of process parameters on power consumption and erosion rate, the aim was to provide valuable insights for system design and operation. The research combines theoretical considerations, CFD simulations, and numerical calculations to analyse the behaviour of the system
This paper will examine if U.S. foreign aid to Colombia had any effect on unemployment rates in the country from 2000-2008. The anti-drug policy Plan Colombia’s success will be assessed and how the policy, which consisted of military and social aid, was able to reduce unemployment numbers. The analysis will be a case study using a qualitative method of interpreting trends from longitudinal and cro
In recent years, several men in Sweden have been acquitted of different sexual offences because the courts deemed that it could have occurred in their sleep. According to a leading expert, several of the Swedish acquitting cases are based on incorrect or irrelevant arguments and reasoning regarding sexsomnia. Therefore, it is important to gain a deeper understanding of how sexsomnia manifests with
