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BACKGROUND: The association between knee alignment and knee pain in knee osteoarthritis (OA) is unclear. High tibial osteotomy, a treatment option in knee OA, alters load from the affected to the unaffected compartment of the knee by correcting malalignment. This surgical procedure thus offers the possibility to study the cross-sectional and longitudinal association of alignment to pain. The aims

The mammary parenchyma is a complex arrangement of tissues that can greatly vary among individuals, potentially masking cancers in breast screening images. In this work, we propose a Simplex-based method to simulate anatomical patterns and textures seen in digital breast tomosynthesis. Our approach involves selecting appropriate Simplex noise parameters to represent distinct categories of breast p

BackgroundNon-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. For many loci, however, the mechanisms through which non-coding variants influence diabetes susceptibility are unknown.ResultsWe examine splicing QTLs (sQTLs) in pancreatic islets fro

Introduction: Alpha-1-antitrypsin (AAT) has been shown to inhibit SARS-CoV-2 cell entry and suggested as a therapeutic agent for COVID-19. Furthermore, epidemiological association of high prevalence of Alpha-1-antitrypsin deficiency (AATD) and regional severity of COVID-19-impact has been hypothesized. In our study setting, the estimated prevalence rates of mild (PI*MZ, PI*SS or PI*MS) and moderat

We apply the statistical sparse jump model, a recently devel-oped, interpretable and robust regime switching model, to infer key featuresthat drive the return dynamics of the largest cryptocurrencies. The algorithmjointly performs feature selection, parameter estimation, and state classifica-tion. Our large set of candidate features are partly based on cryptocurrency,sentiment and financial market We apply the statistical sparse jump model, a recently devel-oped, interpretable and robust regime switching model, to infer key featuresthat drive the return dynamics of the largest cryptocurrencies. The algorithmjointly performs feature selection, parameter estimation, and state classifica-tion. Our large set of candidate features are partly based on cryptocurrency,sentiment and financial marke

This chapter examines the media production of the US Office of War Information (OWI) in Stockholm, 1942–1945. While previous research has focused on the organization of OWI and the American view on war propaganda in Scandinavia, little emphasis has been placed on the actual production and circulation of American propaganda in Sweden during World War II. Drawing on previously neglected archival mat

In celiac disease, intestinal transglutaminase (TG2) produces immunogenic peptides by deamidation of gluten proteins. These products drive the celiac immune response. We have previously identified an interaction between gliadin and a food additive, E304i, which prevents gliadin processing (both deamidation and transamidation) by TG2, in vitro. In this study, we investigated if E304i could prevent

Three different circulation mechanisms are analyzed: 1) through-flow of a river; 2) wind generated oscillations; and 3) convective currents induced by heat flow from the bottom sediments. The through-flow takes place between the ice and a depth, which is mainly determined by the conditions at the inlet of the river into the lake. Just below this depth there is a sharp thermocline. The water mass b

Cells have an incredible ability to physically interact with neighboring cells and their environment. They can detect and respond to mechanical forces by converting mechanical stimuli into biochemical signals in a process known as mechanotransduction. This is a key process for the adaption of vascular smooth muscle and endothelial cells to altered flow and pressure conditions. Mechanical stimuli,

Little is known about the genetic determinants of medication use in preventing cardiometabolic diseases. Using the Finnish nationwide drug purchase registry with follow-up since 1995, we performed genome-wide association analyses of longitudinal patterns of medication use in hyperlipidemia, hypertension and type 2 diabetes in up to 193,933 individuals (55% women) in the FinnGen study. In meta-anal

Vasopressin is a pleiotropic hormone that controls body fluid homeostasis. Vasopressin has also been proposed to be involved in erythropoiesis, thrombocyte activity and inflammation. However, whether increasing vasopressin is associated with changes in hematopoietic markers is not known. To evaluate this gap of knowledge we measured the vasopressin marker copeptin and markers of erythropoiesis (er

After a tank has been exposed to crash violence, or an external fire, it might, in some situations, be judged dangerous to move the vessel due to the risk of a sudden tank rupture. Therefore, Swedish rescue services have a long history of using rifles to penetrate and therefore depressurize the vessels. In this paper, some first steps on providing guidance on the selection of ammunition and requir

This study examines the integration of climate change and biodiversity into business strategies and governance structures of listed firms on the Swedish stock exchange NasdaqOMX Large Cap. The results show clear disparities in the level of integration and the factors driving the integration process. All, but a few small firms, have integrated climate change into business strategies, and are ahead

Diabetes is an escalating health concern affecting approximately 152.6 million people globally in rural areas, with a significant rise in low- and middle-income countries where over 75% of affected adults live. These populations face unique challenges, including delayed diagnosis, limited access to specialized care, and economic hardships, leading to severe complications such as cardiovascular dis