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Background: An audit of all patients with rectal cancer in Sweden was launched in 1995. This is the first report from the Swedish Rectal Cancer Registry (SRCR). Methods: Between 1995 and 2003, 13 434 patients treated for adenocarcinoma of the rectum were registered with the SRCR; there were approximately 1500 new patients annually. Results: Approximately half had an anterior resection, a quarter a
Background: A major part of medical pathology in internal medicine is associated with chronic alcoholism. The aim of the current study was to investigate whether screening for Alcohol Use Disorders (AUD) can be improved through determination of direct ethanol metabolites compared to traditional biological state markers, the Alcohol Use Disorders Identification Test (AUDIT) and additional self-repo
An east-west gradient in cardiovascular mortality has been reported from the region of mid-Sweden. Postal questionnaire studies found that the risk factor distributions among middle-aged men were similar in areas with striking differences in cardiovascular mortality. In this study, 120 randomly selected 50-year-old men in two high mortality communities in the west and 120 men from two low mortalit
Background and Study Aims: Sedation and monitoring practice during colonoscopy varies between centers and over time. Knowledge of current practice is needed to ensure quality of care and help focus future research. The objective of this study was to examine sedation and monitoring practice in endoscopy centers internationally. Patients and Methods: This observational study included consecutive pat
Ferrochelatase (EC 4.99.1.1) catalyzes the last reaction in the heme biosynthetic pathway. The enzyme was studied in the bacterium Bacillus subtilis, for which the ferrochelatase three-dimensional structure is known. Two conserved amino acid residues, S54 and Q63, were changed to alanine by site-directed mutagenesis in order to detect any function they might have. The effects of these changes were
Granins are major constituents of dense-core secretory granules in neuroendocrine cells, but their function is still a matter of debate. Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B (CgA and CgB), are involved in granulogenesis and protein sorting. Here we report the generation and characterization of mice lacking chromogranin B (
Scand J Caring Sci; 2011 Individual placement and support - a model to get employed for people with mental illness - the first Swedish report of outcomes Lack of participation in the open labour market is highly prevalent for people with a mental illness across countries, and the proportion of people who get some kind of sickness benefit because of mental illness is steadily growing in Europe. Voc
BACKGROUND: Prognostic and treatment-predictive biomarkers in primary breast cancer are routinely analyzed in the primary tumor, whereas metastatic tumor cells in lymph node metastases are not characterized. The present study aimed to define the concordance between biomarkers in matched pairs of breast cancers and lymph node metastases and to relate their expression to clinical outcome. METHODS: P
Respiratory proteins such as myoglobin and hemoglobin can, under oxidative conditions, form ferryl heme iron and protein-based free radicals. Ferryl myoglobin can safely be returned to the ferric oxidation state by electron donation from exogenous reductants via a mechanism that involves two distinct pathways. In addition to direct transfer between the electron donor and ferryl heme edge, there is
Inom kärnkraftsindustrin är säkerhet den aspekt som prioriteras högst. Alla kärnkraftverk är designade för att i högsta möjliga mån förhindra läckage av radioaktivetet till omgivningen, både under drift och i händelse av en allvarlig olycka. Med anledning av detta är reaktorinneslutningens vägg en av de viktigaste säkerhetsrelaterade konstruktionerna vid en anläggning, detta då denna konstruktionSafety is the top priority at a nuclear facility. The nuclear power plants are designed to prevent radioactive leakage to the surroundings, both during normal operation as well as in case of a severe accident. One of the most important structures in a nuclear power plant, with regard to safety, is thus the reactor containment wall. The containment wall is the last main barrier to prevent radioacti
Although average life expectancy has increased considerably in Sweden, there is less evidence for improved self-rated health (SRH). We analyzed longitudinal trends in SRH between 1980/1981 and 2004/2005 in age and birth cohort subgroups.
Popular Abstract in Swedish Jorden i vår natur är en mycket komplex miljö som innehåller en mängd olika organismer. Bland dessa är bakterier och svampar av störst betydelse eftersom de står för en stor del av nedbrytningen av olika ämnen. Jordbakterierna utför t.ex. många av ämnesomvandlingarna av kväve, svavel och fosfor i marken. Nedbrytningen frigör näringsämnen som sedan kan utnyttjas av växteThe soil bacterial community is under the constant influence of its environment. Changing any of the factors affecting the bacterial community will induce a selection pressure which, with time, will change the community. In this work the effect of changing the temperature or pH on the soil bacterial community was studied. Measurements using the [3H]-thymidine incorporation technique showed that th
Abstract in Undetermined This paper describes the Swedish-Polish Sustainable Energy Platform, its background, purpose and goals, as well as the partnerships between Sweden and Poland to establish this initiative. The paper also outlines a project initiated by the Swedish-Polish Sustainable Energy Platform to describe and analyze sustainable energy systems in Sweden, particularly from the perspecti
The volume provides a first-ever comprehensive account of the concept and the role of the family in EU law. It explores the family in EU law from four different angles. The first part of the book considers the philosophical and theoretical foundations of the family in the law in general, including the definition of the family under EU law. The second part provides an overview of the rights conferr
