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Background The clinical distinction between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) is sometimes difficult, particularly in mild cases. Although CSF markers such as amyloid beta 42 (A beta 42) and P-tau can distinguish between AD and normal controls, their ability to distinguish between AD and DLB is not adequate. Objective This study aims to investigate whether CSF markers, i
Genetic predisposition for cardiovascular disease (CVD) is likely to be modified by environmental exposures. We tested if the associated risk of CVD and CVD-mortality by the single nucleotide polymorphism rs4977574 on chromosome 9p21 is modified by life-style factors.
Popular Abstract in Swedish Att kunna resa och transportera gods är en del av människors vardag i dagens samhälle. De flesta av dessa transportmedel använder förbränningsmotorer på grund av dess flexibilitet, låg global kostnad och lång körsträcka. Utsläpp i olika former är en oönskad biprodukt av förbränningsmotorer som är skadlig både för människor och för miljön. Diesel motorer är idag bland deInternal combustion engines have been an important technological field for more than a century. It has had an important impact on society through improved transportation and industrial applications. However, concerns about environmental effects of exhaust gases and utilization of oil resources have pushed development of combustion engines towards cleaner combustion and higher efficiencies. The d
This study spatially analyzes plant phenology and its variations over time in mainland Spain and the Balearic Islands. To conduct the analysis, a nearly 40-year span time series (1983-2020) was generated by merging NDVI vegetation index values from satellite images sourced from NOAA-AVHRR and MODIS sensors. The phenological variables were calculated using TIMESAT 3.3, which extracted 13 phenometri
The integration of high-precision cellular localization and machine learning (ML) is considered a cornerstone technique in future cellular navigation systems, offering unparalleled accuracy and functionality. This study focuses on localization based on uplink channel measurements in a fifth-generation (5G) new radio (NR) system. An attention-aided ML-based single-snapshot localization pipeline is
Background: Tissue factor (TF), encoded by the F3 gene, is the main initiator of blood coagulation. The molecular epidemiology of the F3 gene and the relation to venous thromboembolism (VTE) remains to be determined. Objectives: The aim was to determine the molecular epidemiology and the importance of F3 variants for incident VTE by analysis of the population-based MDC study (Malmö Diet and Cancer
The Furongian Słowińska Formation in Poland yielded minute three-dimensionally preserved, phosphatic fossils. Based on shape and structure, two distinct types are identified. The first type comprises sinuously folded, coiled, or spiral string-shaped specimens, interpreted as faecal material, coprolites. The specimens measure between less than one and two mm, the strings being long and against thei
Background Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking. Methods We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions part
Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well
Introduction: We have previously adapted a clinical linear accelerator (Elekta Precise, Elekta AB) for ultra-high dose rate (UHDR) electron delivery. To enhance reliability in future clinical FLASH radiotherapy trials, the aim of this study was to introduce and evaluate an upgraded beam control system and beam tuning process for safe and precise UHDR delivery. Materials and Methods: The beam contr
Molecular blood biomarkers are lacking for high-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN). To histologically distinguish between neuroendocrine carcinoma (NEC), neuroendocrine tumors G3 (NET G3), adenocarcinoma and MINEN is often challenging. The mRNA-based NETest has diagnostic, prognostic and predictive value in neuroendocrine tumors G1-2 but has not been studied in
There is an increasing need for new biomarkers to improve prediction of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D). We aimed to identify blood-based epigenetic biomarkers associated with incident CKD and develop a methylation risk score (MRS) predicting CKD in individuals with newly diagnosed T2D. DNA methylation was analyzed epigenome wide in blood from 487 individuals
Tree recruitment forms an essential process in forest growth models as it determines the amount and composition of the next generation of trees and, hence, the provision of forest ecosystem services over long time spans. With global change and the hereby associated changes in environmental conditions and forest management adaptations, the common static tree recruitment modelling approaches have be
BACKGROUND/AIMS: Ventricular-arterial coupling (VAC) plays a crucial role in cardiovascular physiology, affecting cardiac function and arterial properties for optimal organ perfusion. Considering that diabetes mellitus (DM) is a known risk factor for incident heart disease and vascular damage, this study aims to investigate whether changes in VAC due to DM occur earlier, even before the onset of c
Species-based ecological indices, such as Ellenberg indicators, reflect plant habitat preferences and can be used to describe local environment conditions. One disadvantage of using vegetation data as a substitute for environmental data is the fact that extensive floristic sampling can usually only be carried out at a plot scale within limited geographical areas. Remotely sensed data have the pote
BACKGROUND: Atrial myopathy refers to structural and functional cardiac abnormalities associated with atrial fibrillation and stroke, but appropriate diagnostic criteria are lacking.OBJECTIVES: This study aimed to assess prevalence, clinical correlates, and overlap between potential atrial myopathy markers.METHODS: The population-based SCAPIS (Swedish CArdioPulmonary bioImage Study) prospectively
Whereas autonomic dysfunction and the metabolic syndrome are clinically associated, the relationships with the plasma metabolome is unknown. We explored the association between orthostatic blood pressure responses and 818 plasma metabolites in middle-aged subjects from the general population. We included 3803 out of 6251 subjects (mean age, 57 years; 52% women) from the Malmö sub-cohort of The Swe
