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The targeting mechanisms for granule proteins in hematopoietic cells are largely unknown. Aggregation is believed to be important for protein sorting-for-entry and sorting-by-retention in endocrine and neuroendocrine cells. We asked whether artificially induced multimerization/aggregation of chimeric proteins could affect their sorting in hematopoietic cells. A system was used that permits ligand-
Objectives The aim was to psychometrically evaluate the Swedish version of the Multidimensional Pain Inventory (MPI-S) and the “brief screening version of MPI-S” for use in an elderly sample. Methods This study comprised 175 people aged 76–99 years reporting pain and in need of help to manage daily living. The instrument’s factor structures were investigated through factor analyses, convergent
X-linked retinitis pigmentosa (XLRP) is a severe form of inherited progressive retinal degeneration. The RP3 (retinitis pigmentosa type 3) locus at Xp21.1 is believed to account for the disease in the majority of XLRP families. Linkage analysis and identification of patients with chromosomal deletion have refined the location of the RP3 locus and recently have led to the cloning of the RPGR (retin
3-Hydroxy fatty acids (3-OH FAs) of 10-18-carbon chain lengths are constituents of the lipopolysaccharide of Gram-negative bacteria. These acids are used as chemical markers for determining endotoxin in environmental samples. The present communication addresses the question whether this type of analysis also would be applicable to mammalian samples. Low levels (6.1 +/- 1.6-94.0 +/- 23.2 pmol/ml) o
Mantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a rare disease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment. This works aimed to (I) investigate outcome in relation to primary treatment in MCL based on population-based registry data, (II) to evaluate tolerability and efficacy of lenalid
Background: Participation in everyday life and society is generally seen as essential for health-related outcomes and acknowledged to affect older people’s well-being. Aims: To investigate if aspects of performance- and togetherness-related participation influence on mortality among very old single living people in Sweden. Methods: ENABLE-AGE Survey Study data involving single-living participants
Det ökande byggandet av stadsvägtunnlar, de alpina tunnelolyckorna runt millennieskiftet, och det efterföljande EU-direktiv (2004/54/EC) med minimikrav gällande brandsäkerhet har placerat brandsäkerhet i vägtunnlar högt på dagordningen. Samtidigt är moderna enkelriktade vägtunnlar ofta bland de säkraste delarna av vägsystemet. Har vi kommit till en punkt där resurserna används bättre någon annanstThis thesis can be described as a journey in performance-based fire safety design. Along the way questions such as what fire safety is, how it can be measured, whether we are posing the right questions, or engineer the best solutions, have arisen. The safety journey naturally started out with the traditional view, with fire safety engineering based on limit-based design. Using this paradigm the sa
Classical dendritic cells (cDC) can be classified into two major subsets: Irf8-dependent cDC1 and Irf4-expressing cDC2. Although these subsets play distinct roles in intestinal immune homeostasis, their functions in T cell-driven colitis remain unknown. To assess the role of IRF4 expression in cDC2 in T cell-driven colitis, CD11c-Cre.Irf4fl/fl and Irf4fl/fl mice were backcrossed onto a Rag-1-/- ba
MrpA and MrpD are homologous to NuoL, NuoM and NuoN in complex I over the first 14 transmembrane helices. In this work, the C-terminal domain of MrpA, outside this conserved area, was investigated. The transmembrane orientation was found to correspond to that of NuoJ in complex I. We have previously demonstrated that the subunit NuoK is homologous to MrpC. The function of the MrpA C-terminus was t
This chapter sketches some of the societal dynamics that Gezi protests have expressed and the ways in which they constitute a significant departure from both the conceptualization and practice of politics in contemporary Turkey, through an interrogation of the politics of space that has occupied center stage in the protests.
Popular Abstract in Swedish Inom science och technology centre (STC)-rörelsen finns det uttalade mål och ambitioner att öka allmänhetens intresse och förståelse för naturvetenskap. Samtidigt ifrågasätter många forskare de val som görs vad gäller utställningarnas innehåll och hävdar att det är vanligt att en alltför produktorienterad syn på naturvetenskap presenteras. Men vilka bilder och aspekter Within the science and technology centre (STC) movement there exists explicit aims and ambitions to enhance visitors’ interest in and knowledge about science. Meanwhile, several researches question the choice of the scientific content in exhibitions when arguing that a too unproblematic view of science commonly is presented. But what images and aspects of science are visitors actually confronted w
The aim of the present cross-sectional study was to examine how subjective experiences of engagement in patterns of daily occupations (gainful employment, domestic work, enjoyable and recreational occupations) were associated with perceived health among women of working age. The sample (n=488) was drawn from a longitudinal cohort study of women of working age in Gothenburg, Sweden. Participants we
Kurskod/Course code 1. Identifikation och grundläggande uppgifter 1. Kurskod SVE B01 2. Kursens namn Retorik och argumentationsanalys 3. Nivå G 4. Högskolepoäng 15 5. Beslutsuppgifter Fastställd av kursplanegruppen för Området för humaniora och teologi 2007-03-13 6. Ändringsuppgifter 2. Allmänna uppgifter 1. Huvudområde/n, om tillämpligt 2. Ämne, om tillämpligt Svenska 3. Typ av kurs och dess plac
https://www.sol.lu.se/media/utbildning/dokument/kursplaner/SVEB01.pdf - 2026-07-07
Osteoarthritis is a multifactorial degenerative disease characterized by the breakdown of articular cartilage (AC), affecting hundreds of millions of people worldwide. Among many treatment options, hydrogels have emerged as promising candidates for cartilage replacement, due to their structural resemblance to the native tissue. Hydrogels can be made from various materials, and this study focuses o
