Filtyp
Branched tubular networks constitute the basic structure of many organs to increase surface area and to transport fluids and gases. Glandular organs such as the pancreas arise from multilayered epithelium, which undergoes de novo lumen formation and extensive remodeling and branching. Endocrine cells originate from endocrine progenitors within the ductal epithelium. Upon differentiation into hormo
Multiple sclerosis (MS) is an immune-mediated demyelinating and neurodegenerative disease of the central nervous system (CNS). Neuroinflammatory processes in MS are believed to lead to damage and leakage in the blood-brain barrier that protects the CNS and regulates the trafficking of soluble mediators and leukocytes. MS is thought to be triggered in genetically susceptible individuals following e
This paper discusses how the author, a Japanese expatriate living in Sweden, perceives packaging in Sweden. Concentrating primarily on the cultural aspect, the paper focuses on the similarity and differences found in 1) the usage of packaging as well as 2) source separation systems for packaging waste. Concerning the usage, the main differences are found in the way packaging is used to keep the qu
The i.v. and i.m. dose pharmacokinetics of ceftazidime 1 g b.i.d. were investigated in steady state in 52 consecutive cases of hospitalised patients with underlying diseases and serious supervening bacterial infections. Following i.v. bolus injection, serum concentrations of greater than 4 mg/l persisted for 8 h in all patients. Compared to values found in younger patients studied previously, clea
The present doctoral thesis is a study of the problem of "variation" in relation to word-stress in Russian adjectives, in both their short and long forms. The stress variation in adjectival forms is investigated from various viewpoints, the main of which is the revelation of the basic processes of stress reorganisation in these groups of words and the establishment of main tendencies of adjectival
Dimethylaminopurine (DMAP) has previously been used as an inhibitor of phosphorylation in studies of meiotic events, and more recently to investigate TNFα signaling, because of its potential to inhibit activation of c-jun N-terminal kinase (JNK). Here we have addressed the effects of DMAP on metabolic insulin responses in adipocytes and on intracellular insulin signaling molecules. At 100 μmol/L,
Groups of male mice were exposed via inhalation to methylene chloride, perchloroethylene, toluene, trichloroethylene or 1,1,1-trichloroethane. The exposures were started at 2300 h. Generation of vapor was stopped after 1 h. Motor activity of the animals during the exposures was measured with a Doppler radar. Several concentrations of each solvent were tested. Concentrations could be found for all
[abstract missing]
An automated high-performance liquid chromatographic (HPLC) method has been developed for measurement of 5-S-cysteinyl-DOPA in urine (DOPA = 3,4-dihydroxyphenylalanine). The urinary sample was injected into an HPLC boronate column. With a mobile phase of 0.1 M phosphate buffer containing 0.2 mM disodium ethylenediaminetetraacetate (Na2EDTA) (pH 6.0) mixed with methanol (9:1), 5-S-cysteinyl-DOPA wa
Previous work has shown that the lips are moving at a high velocity when the oral closure occurs for bilabial stop consonants, resulting in tissue compression and mechanical interactions between the lips. The present experiment recorded tongue movements in four subjects during the production of velar and alveolar stop consonants to examine kinematic events before, during, and after the stop closur
Patients with dysphagia, heartburn and chest pain are regularly referred for radiologic evaluation of swallowing. The liquid barium swallow has been of great value for the biphasic evaluation of the pharynx and esophagus. Though many patients complain of dysphagia specifically for solids, solid bolus swallow is usually not part of the evaluation. For the present study we therefore included the use
Inflammatory bowel disease (IBD, i.e. primarily Crohn's disease and ulcerative colitis) is characterised by a chronic or relapsing inflammation of the digestive tract. The thiopurine drugs 6-mercaptopurine (6-MP) and azathioprine (AZA, an imidazol derivative and pro-drug of 6-MP) are currently used to an increased extent in IBD, particularly in Crohn's disease. Metabolism of thiopurines is comple
The three-dimensional structure of Bruton's agammaloglobulinemia tyrosine kinase (Btk) SH2 domain was modeled based on v-Src. Btk SH2 is presumably very related to the other SH2 structures consisting of two beta-sheets surrounded by two alpha-helices, with a well conserved hydrophobic core and phoshotyrosyl peptide binding site. The model was used to predict the recognition sequence of the target
Low-temperature absorption and fluorescence spectra of fully active cores and membrane-bound PS II preparations are compared. Detailed temperature dependence of fluorescence spectra between 5 and 70 K are presented as well as 1.7-K fluorescence line-narrowed (FLN) spectra of cores, confirming that PS II emission is composite. Spectra are compared to those reported for LHCII, CP43, CP47 and D1/D2/c
BACKGROUND: Hip dislocation in children with cerebral palsy (CP) is a common and severe problem. The dislocation can be avoided, by screening and preventive treatment of children with hips at risk. The aim of this study was to analyse the characteristics of children with CP who develop hip displacement, in order to optimise a hip surveillance programme. METHODS: In a total population of children w
