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Aims: Treatment with implantable cardioverter-defibrillators (ICD) is a cornerstone for prevention of sudden cardiac death in arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed at describing the complications associated with ICD treatment in a multinational cohort with long-term follow-up. Methods and results: The Nordic ARVC registry was established in 2010 and encompasses a large m
This paper examines how and why the Norwegian government’s early handling of the Covid-19 pandemic became constructed as a centre–periphery issue in public discourse. By analysing opinion pieces and editorials published in a North Norwegian regional newspaper during the first months of the outbreak, it identifies how a ‘northern peripherality’ discourse emerged and highlighted geographical, infras
Summary: Microstructures from the millimeter- tonanometer scale have been studied and described in ametal nodule from the Vaca Muerta mesosiderite. Ourobservations are interpreted in the context of formationmechanisms.
A recent theoretical model by Andersson et al. proposes that soft gluons order themselves in the form of a helix at the end of the QCD cascades. The Authors of the model present a measure of the rapidity-azimuthal angle correlation, which they call screwiness. We searched for such a signal in DELPHI data, and found no evidence for screwiness.
Lead has traditionally been added to brass alloys to achieve high machinability, but the exact mechanisms at work are still debated. Lead-free brass alternatives could be developed if these mechanisms were better understood. Accordingly, machinability characteristics were investigated for two brass alloys with similar mechanical properties and phase composition, but with very different machining c
The purpose of this study is to look into patronage effects of extended supply outside peak hours on regional public transport services. Previous studies have shown that the service frequency is an attribute of great importance for regional passengers, but little is known about the details regarding peak and off-peak frequencies or service hours. The present study addresses this knowledge gap, dep
This paper explores the idea of the entrepreneurial university and how it differs in diverse regional and institutional settings. From the analysis of university engagement in a regional economic development programme in fifteen city-regions in England (UK), this study identifies three roles that entrepreneurial universities play in regional economic development as growth supporter, steerer, and d
In this paper we describe how to determine the time delays caused by synchronous and asynchronous control loops. These time delays can vary in a quite irregular way and can cause problems for the control loops closed over a communication network of, for instance, field-buses. Different setups allowing an arbitrary number of communication layers are analyzed. The theoretical derivations are illustr
Unique 4D deformation data are collected during drained triaxial tests on intact specimens of a natural sensitive clay. This required the development of a miniature triaxial cell for advanced stress path testing, specifically designed for X-ray Computed Tomography (XCT). Salient features include the omission of membrane, and a mounting procedure that minimises disturbance from the experimenter. Th
Context: Maturity onset diabetes of the young, type 8 (MODY8) is associated with mutations in the CEL gene, which encodes the digestive enzyme carboxyl ester lipase. Several diabetes cases and families have in recent years been attributed to mutations in CEL without any functional or clinical evidence provided. Objective: To facilitate correct MODY8 diagnostics, we screened 2 cohorts of diabetes p
We provide an abstract approach to approximation with a wide range of regularity classes X in spaces of pseudocontinuable functions Kp Θ, where Θ is an inner function and p > 0. More precisely, we demonstrate a general principle, attributed to A. Aleksandrov, which asserts that if a certain linear manifold X is dense in Kq Θ for some q > 0, then X is in fact dense in Kp Θ for all p > 0. Moreover,
Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal and eye diseases, respectively. Binding of soluble complement inhibitors to the ECM, including factor H (FH), is important to prevent excessive comp
Aquaporins (AQPs) are water channels embedded in the cell membrane that are critical in maintaining water homeostasis. We describe a protocol for determining the water permeation capacity of AQPs reconstituted into proteoliposomes. Using a stopped-flow setup, AQP embedded in proteoliposomes are exposed to an osmogenic gradient that triggers water flux. The consequent effects on proteoliposome size
Aims: To accommodate surplus energy, adipose tissue expands by increasing both adipose cell size (hypertrophy) and cell number (hyperplasia). Enlarged, hypertrophic adipocytes are known to have reduced insulin response and impaired glucose transport, which negatively influence whole-body glucose homeostasis. Rosiglitazone is a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, known
In recent decades, tech-companies such as Amazon, Google, Facebook, and Apple have grown exponentially, and it can be tempting for cities to try to attract these powerful corporations. This paper explores a particular aspect of this development, namely, how cities brand themselves to win the favor of a single big business. We draw on institutional isomorphism and a case study of North American cit
Islet dysfunction is central in type 2 diabetes and full-blown type 2 diabetes develops first when the beta cells lose their ability to secrete adequate amounts of insulin in response to raised plasma glucose. Several mechanisms behind beta cell dysfunction have been put forward but many important questions still remain. Furthermore, our understanding of the contribution of each islet cell type in
