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Recent studies of isolated human islets have shown that glucose induces hormone release with repetitive pulses of insulin and somatostatin in antisynchrony with those of glucagon. Since the mouse is the most important animal model we studied the temporal relation between hormones released from mouse islets. Batches of 5-10 islets were perifused and the hormones measured with radioimmunoassay in 30
Purpose: To address the systematic bias in whole-brain dual flip angle (DFA) T1-mapping at 7T by optimizing the flip angle pair and carefully selecting RF pulse shape and duration. Theory and Methods: Spoiled gradient echoes can be used to estimate whole-brain maps of T1. This can be accomplished by using only two acquisitions with different flip angles, i.e., a DFA-based approach. Although DFA-ba
During fracture of membranes loading often produces buckles above and below the cracksurface. This changes the stress state surrounding the crack-tip and stresses in theneighbourhood of the crack-tip posses a weaker singularity than r-1/2. As a result, fractureoccurs when the crack-tip stress distribution is different as compared with that when bucklingis artificially prevented. Therefore the cond
RATIONALE: Neutrophils likely contribute to the thrombotic complications of human atheromata. In particular, neutrophil extracellular traps (NETs) could exacerbate local inflammation and amplify and propagate arterial intimal injury and thrombosis. PAD4 (peptidyl arginine deiminase 4) participates in NET formation, but an understanding of this enzyme's role in atherothrombosis remains scant.OBJECT
In order to better understand the relations between different risk factors in the predisposition to type 2 diabetes, we present a Bayesian Network analysis of a large dataset, composed of three European population studies. Our results show, together with a key role of metabolic syndrome and of glucose after 2 hours of an Oral Glucose Tolerance Test, the importance of education, measured as the num
A single bout of electroacupuncture results in muscle contractions and increased whole body glucose uptake in women with polycystic ovary syndrome (PCOS). Women with PCOS have transcriptional and epigenetic alterations in the adipose tissue and we hypothesized that electroacupuncture induces epigenetic and transcriptional changes to restore metabolic alterations. Twenty-one women with PCOS receive
The large spatial variability in Arctic tundra complicates the representative assessment of CO2 budgets. Accurate measurements of these heterogeneous landscapes are, however, essential to understanding their vulnerability to climate change. We surveyed a polygonal tundra lowland on Svalbard with an unmanned aerial vehicle (UAV) that mapped ice-wedge morphology to complement eddy covariance (EC) fl
Aim: The aim of this thesis was to identify risk factors for type 1 diabetes in children, evaluate the effects of participation in prospective follow-up and the safety of immune tolerance treatment with GAD-Alum in children with islet autoimmunity.Methods: Subjects from the Swedish DiPiS cohort were studied regarding risk factors, cord blood islet autoantibodies and the effects of early severe lif
Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and in-tegrated into the genome of human cells. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro.
Homelessness and other forms of destitution among asylum-seeking migrants are currently on the rise across Europe, as migrants’ access to social rights, including housing, has been restricted through repressive migration policies, fuelled by the welfare nationalism and chauvinism that surge among European states. This article explores the largely overlooked homelessness experienced by migrants seeHomelessness and other forms of destitution among asylum-seeking migrants are currently on the rise across Europe, as migrants’ access to social rights, including housing, has been restricted through repressive migration policies, fuelled by the welfare nationalism and chauvinism that surge among European states. This article explores the largely overlooked homelessness experienced by migrants see
Background: The majority of childhood cancer survivors are at risk of treatment-related adverse health outcomes. Survivorship care to mitigate these late effects is endorsed, but it is not available for many adult survivors of childhood cancer in Europe. The PanCareFollowUp project was initiated to improve their health and quality of life (QoL) by facilitating person-centred survivorship care. Met
The role of the newly discovered estrogen receptor GPR30 in islet physiology and pathophysiology is unclear. We examined GPR30 expression in relation to hormone secretion and possible anti-apoptotic effects in isolated mouse islets using the synthetic GPR30 ligand G-1. The mRNA and protein expression of GPR30 was analyzed by qPCR, Western blot and confocal microscopy. Hormone secretion and cAMP co
It is hoped that information garnered from studies on population genetics will one day be translated into a form in which it meaningfully improves the prediction, prevention or treatment of type 2 diabetes. Type 2 diabetes genetics researchers have made extraordinary progress in identifying common genetic variants that are associated with type 2 diabetes, which has shed light on the biological pat
The national Swedish policy on alcohol has been eroded since the country joined the European Union (EU) in 1996, leading to a steep increase in the private import of alcohol. The paper investigates the impact on drinking patterns of the greater availability of alcohol among adolescents. Two cross-sectional data sets, collected in 2003 (n = 2,760) and 2005 (n = 2,031) in schools in southern Sweden,
The rising prevalence of type 2 diabetes among migrant populations from low- and middle-income countries (LMICs) living in high-income countries (HICs) presents a significant public health challenge. Migrants often experience lifestyle changes, socioeconomic disadvantages and barriers to accessing healthcare, which can increase their risk for type 2 diabetes. This review explores the prevention an
Det har länge varit känt att aktivt lärande, exempelvis i form av att ställa frågor till sig själv på material som ska läras in, är effektivt. Trots detta finns ibland ett motstånd hos såväl lärare som studenter mot nya undervisnings- och examinationsformer (Carpenter, 2023). I testbaserat lärande (eng. retrieval practice) utgår man från att inlärningseffekten förstärks om personen som ska lära ge
Issues of democracy and the greater debate on development cannot go without an examination of the various agencies that play a role in the larger development agenda and in political participation in particular, including NGOs and the Media. Here media refers to both traditional media of television, radio and press and social media and WEB 2.0. The case of YALI and the constitution making process i
Abstract The thesis is aimed to conduct research on rule of law as instrument for national development and to investigate the relationship between rule of law and development in rights based approach. Rule of law in relation to development will be examined to what extent it functions in practical development course of action. The study also aims at highlighting rule of law and spark light how it c
