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In their roles as purchasers, users and dischargers of used products, consumers play an important role in the circular economy. In this article, we put forward a ‘hierarchy of consumption behaviour’ to support European Union policymaking. Among the priorities are avoiding the purchase of single-use and unnecessary products, prolonging the lifetime of products through maintenance and engaging in re
Results of angle-resolved electron spectroscopy of near-threshold photoionization of Ne atoms by combined femtosecond extreme ultraviolet and near infrared fields are presented. The dressed-electron spectra show an energetic distribution into so-called sidebands, being separated by the photon energy of the dressing laser. Surprisingly, for the low kinetic energy (few eV) sidebands, the photoelectr
Jet quenching is one of the major discoveries of the heavy-ion program at Rhic. While there is a wealth of data from Rhic that will soon be supplemented with measurements at the Lhc, on the theoretical side the situation is less clear. A thorough understanding of jet quenching is, however, beneficial, as it is expected that medium-induced modifications of jets allow one to characterise properties
Purpose – The purpose of this paper is to explore, describe and categorise practices of managing product returns empirically in internet retailing.Design/methodology/approach – A multiple case study was conducted involving 12 e-commerce firms and 4 logistics service providers. An integrative data collection approach of semi-structured interviews, documentation and observations was used to gain com
The insect odorant receptors (ORs) are amongst thelargest gene families in insect genomes and the primarymeans by which insects recognize volatile compounds.The evolution of ORs is thus instrumental inexplaining the chemical ecology of insects and as amodel of evolutionary biology. However, althoughORs have been described from numerous insect species,their analysis within and amongst the insectord
In idiopathic pulmonary fibrosis (IPF) structural properties of the extracellular matrix (ECM) are altered and influence cellular responses through cell-matrix interactions. Scaffolds (decellularized tissue) derived from subpleural healthy and IPF lungs were examined regarding biomechanical properties and ECM composition of proteins (the matrisome). Scaffolds were repopulated with healthy fibrobla
The PI3K pathway is a major driver of cancer progression. However, clinical resistance to PI3K inhibition is common. IBL-302 is a novel highly specific triple PIM, PI3K, and mTOR inhibitor. Screening IBL-302 in over 700 cell lines representing 47 tumor types identified neuroblastoma as a strong candidate for PIM/PI3K/mTOR inhibition. IBL-302 was more effective than single PI3K inhibition in vitro,
Encapsulation of proteins within lipid inverse bicontinuous cubic phases (Q2) has been widely studied for many applications, such as protein crystallization or drug delivery of proteins for food and pharmaceutical purposes. However, the use of the lipid sponge (L3) phase for encapsulation of proteins has not yet been well explored. Here, we have employed a lipid system that forms highly swollen sp
Kvantitativ analys är en teknik som syftar till att förstå komplexa system genom att använda matematisk och statistisk modellering. Det är en viktig del av dagens finansiella system och innebär bland annat att modellera den slumpmässiga utvecklingen av finansiella tillgångar, och för att förutspå verkliga händelser som till exempel förändring av riksbankens styrränta. En mycket vanlig metod som anDiffusion processes are the most commonly used models in mathematical finance, and are used extensively not only by academics but also practitioners. Nowadays a wide range of models, that can capture many of the effects observed in financial markets, are available. A very important task is to calibrate the models to observed market data and to achieve a good fit, since a slight misspecification ca
Because of the body's resistance to permanent weight change, obesity remains a major health problem in modern society. It is hypothesized that the regulatory system defending body weight utilizes pancreatic insulin as an indicator of adiposity to the brain. To take advantage of this negative feedback system, we transplanted neonatal (experiment 1) or adult (experiment 2) pancreatic islets containi
Sequences of different sizes are generated when DNA from homozygous HLA-Dw/DR typing cells are digested with restriction endonuclease and analyzed by hybridization with a HLA-D region class II antigen beta-chain cDNA probe. The patterns of hybridization were highly polymorphic but one endonuclease, BamHI, defined sequences unique to all HLA-Dw/DR specificities 1-8 except HLA-Dw/DR 2 and 6; however
The probable role of cell surface antigens in the development of juvenile diabetes necessitates a detailed study of the proteins expressed on the surface of pancreatic β-cells. A gene library composed of genes expressed in β-cells was constructed to provide a source of low abundance genes from those cells. Initial studies with this library have led to the isolation of three genes which share nucle
Dragonflies pursue and capture tiny prey and conspecifics with extremely high success rates. These moving targets represent a small visual signal on the retina and successful chases require accurate detection and amplification by downstream neuronal circuits. This amplification has been observed in a population of neurons called small target motion detectors (STMDs), through a mechanism we term pr
Five daily injections of streptozotocin (40 mg/kg) produced a delayed but progressively increasing level of hyperglycaemia in long term studies with male Naval Medical Research Institute mice and C3D2F1 (DBA 2 J male × C3H/ Tif female) F1 hybrid mice. The development of hyperglycaemia was paralleled by decreased amounts of pancreatic immunoreactive insulin as well as degranulation and necrosis of
Hydrolysis of p nitrophenyl phosphate was measured in a fraction enriched in plasma membranes from pancreatic islets of non inbred ob/ob mice. Hydrolysis was stimulated by K+ (10mM) in the pH range 5-10; a small peak of K+ induced activation was observed between pH 7.5 and 8. Both the K+ induced activation and the hydrolysis in the absence of K+ were Mg2+ dependent; maximum activation was obtained
