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Background: Insulin resistance and impaired insulin secretion are hallmarks of type 2 diabetes (T2D) and may influence risks of complications including dementia. We investigated dementia risk across T2D subgroups defined by beta-cell function and insulin sensitivity. Methods: We used Homeostasis Model Assessment-2 indices of beta-cell function (HOMA2-B) and insulin sensitivity (HOMA2-S) to classif
BackgroundObesity is commonly diagnosed using BMI, which does not capture total adiposity or fat distribution, as highlighted by the recent Lancet D&E Commission report. We assessed the prognostic value of an adiposity-based classification combining body fat percentage (BF%) and waist circumference (WC) in relation to cardiometabolic and kidney outcomes and evaluated its concordance with BMI.M
Carotid sinus massage (CSM) is essential in evaluating recurrent unexplained reflex syncope, as it uniquely identifies cardioinhibitory forms that other tests may miss. CSM is largely underused in clinical practice outside dedicated syncope facilities and, when performed, its execution varies, as does the interpretation of results. Underuse affects the diagnostic yield of CSM in the syncope evalua
The question was asked whether or not it was possible to discern a connection between architecture, house functions and household activities among three-aisled longhouses at Lockarp, Malmö. Traces of postholes, along with the findings of artefacts and burnt herb seeds, constituted the major material culture left for revision by this study. The data used was based on reports from the excavation pro
A three second window has long been suggested by Pöppel (2009) and others, to guide the human perception. More recently,a three second constant has been suggested in overt human behaviour (Schleidt, 1988) as well as in mammalian species in general (Gerstner & Goldberg, 1994). It is however unclear whether this temporal window exists in other vertebrate species. This study examines the existenc
Emerging evidence from diverse populations highlights the therapeutic benefits of the Crohn’s Disease Exclusion Diet (CDED) in managing Crohn’s Disease. To improve the efficacy of the CDED, there is a need to focus on cultural adaptation and individualization to support dietary adherence to this advanced nutritional therapy. This paper provides a theoretical framework for modifying the CDED to ali
BACKGROUND & AIMS: The role of early-life overall diet in celiac disease risk is not well explored. The aim was to investigate associations of dietary diversity, and healthy eating in the second year of life with subsequent celiac disease risk.METHODS: In 64,315 children born 2002-2009 with available data in the Mother, Father and Child Cohort Study, a Dietary Diversity Score (0-4) and Healthy
Autoimmune thyroid disease (AITD) is associated with other autoimmune endocrine diseases such as type 1 diabetes (T1D) and celiac disease (CeD). Thyroid peroxidase autoantibodies (TPOA) are biomarkers of AITD but may also occur in patients with other autoimmune diseases. We examined cross-sectional correlations between TPOA and an array of immune markers in a cohort of 90 children with exclusively
In mouse early pachytene spermatocytes, the X and Y chromosomes undergo rapid non-homologous (NH) synapsis and desynapsis, but the functional significance remains unknown. Here, we report that pachynema-specific knockout of Speedy A (SpdyA) from telomeres caused persistent Y-X NH synapsis, with the entire Y axis synapsed onto the X axis. This persistent Y-X NH synapsis did not interrupt meiotic se
The rising prevalence of type 2 diabetes among migrant populations from low- and middle-income countries (LMICs) living in high-income countries (HICs) presents a significant public health challenge. Migrants often experience lifestyle changes, socioeconomic disadvantages and barriers to accessing healthcare, which can increase their risk for type 2 diabetes. This review explores the prevention an
Aims: Stratifying renal damage in type 2 diabetes is challenging due to overlapping features between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD). While miR-27b-3p modulates kidney fibrosis in DN through the lysine63 ubiquitination pathway, its upstream regulation and diagnostic relevance remain unclear. Methods: In a biopsy-verified cohort of 231 chronic kidney disease (CKD) pa
The importance of immunometabolism in the development of metabolic diseases is clear. Yet, how certain metabolic disorders, such as insulin deficiency (ID), influence immune cell function, and vice versa, is poorly understood. Also, therapeutic strategies to harness the interplay between immune cells and metabolism are lacking. Here, we observe that ID rearranges the immune landscape of the liver,
Popular Abstract in Swedish Avsaltning av havsvatten utgör en viktig källa för vattenförsörjning till befolkningen som bor vid Persiska viken, Medelhavet och Röda havet. De tre regionerna utgör ca 11,8 % av världens landyta och hade omkring 9 % av världens befolkning under 1950 och 2008, samt lika mycket enligt prognos för år 2050. Dessa områden är hemvist för 62 %, 58% och 60% av världens avsaltnIn this M.Sc. Thesis of a comparison for sewerage system of the three main municipalities of Turkish Republic of Northern Cyprus (T R N C) has been studied and discussed. The study covers the future population calculations for three municipalities, Nicosia, Famagusta and Kyrenia, by means of Turkish and European standards. The comparisons for sewerage system of the three municipalities are compare
Background and aim: Children with type 1 diabetes (T1D) represent a heterogeneous group of children with varying genetic backgrounds and different numbers of autoantibodies at diagnosis. The latter may reflect an interaction between genetic susceptibility and environmental triggers that contribute to the onset of the disease. However, the specific triggers remain unknown. The overall aim of this t
Type 1 diabetes, formerly known as juvenile diabetes or insulin-dependent diabetes, results from the specific autoimmune destruction of the pancreatic islet beta cells. The subsequent loss of insulin leads to increased blood and urine glucose. The classical symptoms are polyuria (frequent urination), polydipsia (increased thirst), polyphagia (increased hunger), and weight loss. The disease may be
