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Chondroitin (CS) and dermatan sulphate (DS) are socalled glycosaminoglycans (GAG) that are covalently attached to various type of proteins forming a subgroup within the diverse proteoglycan (PG) family. The PGs studied in this thesis are mostly extracellularly located and include aggrecan, biglycan and decorin. The CS and DS chains both consist of repeating disaccharides of the type (hexuronic aci
Hematopoietic stem cells (HSC) give rise to all types of blood lineages, including red blood cells (RBC). Hematopoietic stem/progenitor cells (HSPC) are known to be functionally diverse in terms of their self-renewal potential and lineage output. Consequently, investigation of molecular heterogeneity in the differentiation potential of HSPC is vital to identify novel regulators that affect generat
Background: In many settings, health care service provision has been modified to managing COVID-19 cases, and this has been affecting the provision of maternal and child health services. The aim of this study was to assess trends in selected maternal and child health services performance in the context of COVID-19 pandemic. Methods: A cross-sectional data review was conducted in Addis Ababa, Ethio
The coronavirus disease 2019 (COVID-19) pandemic has a major impact not only on public health and daily living, but also on clinical trials worldwide. To investigate the potential impact of the COVID-19 pandemic on the initiation of clinical trials, we have descriptively analyzed the longitudinal change in phase II and III interventional clinical trials initiated in Europe and in the United States
Striatal neurons forming the indirect pathway (iSPNs) are particularly vulnerable in Huntington's disease (HD). In this study we set out to investigate morphological and physiological alterations of iSPNs in two mouse models of HD with relatively slow disease progression (long CAG repeat R6/2 and zQ175-KI). Both were crossed with a transgenic mouse line expressing eGFP in iSPNs. Using the open-fie
Fibroblasts synthesize a variety of proteoglycans among which is a family of structurally related small proteoglycans, i.e. PG-S1 (biglycan) and PG-S2 (decorin). Fibromodulin, which is present in some tissues as a keratan sulfate proteoglycan, also belongs to this family. We have used primary fibroblasts from fetal skin and bovine sclera in culture to study the metabolism of proteoglycans. In part
The Indonesian archipelago, Borneo, Sumatra and West New Guinea (Papua), hosts half of the world's known tropical peat swamps, which support a significant proportion of the estimated biodiversity on Earth. However, several species groups that inhabit peat swamp environments remain poorly characterised and their biology, particularly during early life stages, is not well understood. In the present
Electrons from heavy-flavour hadron decays (charm and beauty) were measured with the ALICE detector in Pb–Pb collisions at a centre-of-mass of energy sNN=2.76 TeV. The transverse momentum (pT) differential production yields at mid-rapidity were used to calculate the nuclear modification factor RAA in the interval 3<pT<18 GeV/c. The RAA shows a strong suppression compared to binary sc
The repair jobs that birds have to do to maintain high quality plumage take energy and time, so should be under intense selection. Recently, we have shown that secondary moult in the Eurasian Golden Plover Pluvialis apricaria is incomplete, irregular and asymmetric between wings, and argued that this reflected their ‘relaxed’ migratory habits. On the basis of this hypothesis, we predict that relat
The Willow Warbler (Phylloscopus trochilus, Linnaeus, 1758) is a long distance migrant and one of the most common breeding birds in the Western Palearctic. Its migratory directions have been studied in detail in Scandinavia where a narrow migratory divide is located around 62°30′ N that separates southern SW migrating Phylloscopus t. trochilus from SSE migrating Phylloscopus t. acredula. The shape
Natural killer cells are part of the immune system and one of their main functions is to dispose of cancer cells and virus-infected cells. In order to avoid detection by T cells, cancer cells can decrease the expression of MHC I proteins which instead can make them a target for NK cells, making NK cells a suitable for use in therapy. This study sought to investigate the cytotoxic ability of NK cel
Iron is an important material in the study of societies of the Iron Age and later periods. Not only does it give its name to the period it was also an integrated part in every humans’ life from the Iron Age and forward. And yet this material is many times just assumed to be there without much consideration of how it got there. In this master thesis, the author thus tries to bridge this gap in betw
Domestic workers are an essential part of Vietnam’s urban labour market. However, many are in informal employment, which means they lack needed legal and social protections. In 2014, legal protections were introduced to formalise domestic work in Vietnam. This study aims to increase understanding of the formalisation process of domestic workers in Vietnam. A framework that conceptualises formalisa
The objective of this thesis was the impact evaluation of several parameters affecting daylight conditions in a typical cellular office in Lund, Sweden. The research approach that was followed consisted of three distinct steps; the literature review in order to specify the dependent and independent variables of the study, the simulation part to produce daylight performance data and the graphical a
This research project is intended to provide perspective on the role of leadership and decision-making of managers who are positioned in organizations that deal with crises and security-risks. By giving an insight to managers biographical accounts and combining it with previous leadership publications, this study has focused on what decisions such managers make, and the assessment of their respons
The Swedish Transport Administration (STA) has begun to expand the two lined tracks that run between Flackarp and Arlöv to four tracks. For STA, it is of high importance to manage aspects such as climate and energy issues in big infrastructure projects, especially since they must meet certain requirements. Furthermore, when performing life cycle assessments (LCA) in projects like these, the possib
