Filtyp
The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, "The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis" on 10-12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic
Colour discrimination is based on opponent photoreceptor interactions, and limited by receptor noise. In dim light, photon shot noise impairs colour vision, and in vertebrates, the absolute threshold of colour vision is set by dark noise in cones. Nocturnal insects (e.g. moths and nocturnal bees) and vertebrates lacking rods (geckos) have adaptations to reduce receptor noise and use chromatic visi
We study statistical properties of the 0+ spectrum of 208Pb in the energy region Ex ≤ 20 MeV. We use the Skyrme interaction SLy4 as our model Hamiltonian to create a single-particle spectrum and to analyze excited states. The finite-rank separable approximation for the particle–hole interaction enables us to perform the calculations in large configuration spaces. We show that while the position of
We consider a class of structured covariance completion problems which aim to complete partially known sample statistics in a way that is consistent with the underlying linear dynamics. The statistics of stochastic inputs are unknown and sought to explain the given correlations. Such inverse problems admit many solutions for the forcing correlations, but can be interpreted as an optimal low-rank a
ZNF224 is a member of the Kruppel-associated box zinc finger proteins (KRAB-ZFPs) family. It was originally identified as a transcriptional repressor involved in gene-specific silencing through the recruitment of the corepressor KAP1, chromatin-modifying activities, and the arginine methyltransferase PRMT5 on the promoter of its target genes.Recent findings indicate that ZNF224 can behave both as
In a sample data system we are essentially restricted to control signals which are constant over the sampling interval. The purpose of this report is to analyze the effect of this restriction. The situation where the admissible control signals are piecewise continuous is used as a reference case and the problem is approached from a variational formulation of the control problem where the object o
Background: Effects of increased adenosine dose in the assessment of fractional flow reserve (FFR) were studied in relation to FFR results, hemodynamic effects and patient discomfort. FFR require maximal hyperemia mediated by adenosine. Standard dose is 140 μg/kg/min administrated intravenously. Higher doses are commonly used in clinical practice, but an extensive comparison between standard intra
Digitalization and emergence of new technologies including Artificial Intelligence has shaped new organizational principles for the functioning of economies and societies globally. Technology has also changed the landscape for taxation and interactions between tax administration and taxpayers. Recently various models of electronic reporting and invoicing, split-payment mechanisms as well electroni
The main aim of this article is to discuss the attitudes to mathematics of students taking a basic mathematics course at a Swedish university, and to explore possible links between how well such students manage to solve tasks about limits of functions and their attitudes. Two groups, each of about a hundred students, were investigated using questionnaires, field notes and interviews. From the resu
Entrenchment of multi-word sequences is known to shape native language competence, but there is debate about how (much) it affects L2 speakers. We investigate advanced English learners’ receptive processing of multi-word sequences with a word-monitoring experiment. The effect of reduction on recognition of the word to was tested in English V-to-Vinf constructions of varying surface frequencies and
Deformation mechanisms of crystalline solids has been the subject of research for more than two centuries. The theory of dislocations dominates modern views but still has significant gaps demanding the introduction of additional concepts for the coherent quantitative description of physical phenomena. In this work, we propose a coherent geometric description of motion and deformation in crystallin
Background/aims: Congestion is prognostically relevant in cardiac transthyretin amyloidosis (ATTR-CA), but whether congestion has an incremental prognostic value beyond the well-established, congestion-sensitive NT-proBNP is unknown. Therefore, we aimed to comparatively evaluate the prognostic utility of several congestion surrogates over NT-proBNP. Methods: We estimated hazard ratios by Cox propo
Disruptions in energy homeostasis can lead to diseases like obesity and diabetes, affecting millions of people each year. Tanycytes, the adult stem cells in the hypothalamus, play crucial roles in assisting hypothalamic neurons in maintaining energy balance. Although tanycytes have been extensively studied in rodents, our understanding of human tanycytes remains limited. In this study, we utilized
Starch is generally regarded as safe for human consumption and has therefore attracted interest for several applications as medicinal products. This chapter focuses specifically on starch microspheres as carriers for drug delivery and as a medical device for, for example, vascular occlusion. Several methods for the preparation of starch microspheres by chemical or physical cross-linking are presen
