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Cytokines have been shown to have important roles in lymphopoiesis. However, many questions remain unresolved. Among other, while the action of interleukin (IL)-7 in alpha beta T cell development in mouse seems to be largely mediated through permissive survival signaling, the possible permissive role of IL-7 in early B cell development is disputed. Furthermore, FMS-like tyrosine kinase-3 ligand (F
1 We investigated the antagonistic effect of 1-piperidinecarboxamide, N-[2-[[5amino-1-[[4-(4-pyridinyl)-1-piperazinyl]carbonyl]pentyl]amino]-1 -[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]4-(1,4- dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) on the calcitonin gene-related peptide (CGRP)-induced responses by using isometric myograph and FURA-2 technique in human subcutaneous arteries removed
Metabolic stress is a phenomenon often discussed in conjunction with recombinant protein production in Escherichia coli. This investigation shows how heterologous protein production, and the presence of host cell proteases is related to: i) IPTG induction, ii) cell mass concentration at the time of induction and iii) the presence of metabolites (glutamic acid or those from TSB) during the post ind
Objectives: Phosphodiesterase 5 (PDE5) inhibitors improve smooth muscle relaxation and therefore are considered for pharmacotherapy of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Cyclic guanosine monophosphate (cGMP) -dependent protein kinase-1 (cGKI) has been identified as one of the downstream targets for cGMP. The aim of the present study was to evaluate, by mean
The age and sex-specific incidence and prevalence of vertebral compression fractures were compared between the 1950s and 1980s in an urban population. In women over 80 years of age the incidence of symptomatic vertebral fractures has increased approximately four times; in elderly men even more. Mainly, low-energy trauma has caused these fractures. Thus, one clinical manifestation of osteoporosis--
The purely electronic linewidth delta of terrylene impurity molecules in monocrystalline biphenyl is studied at temperatures T between 1.7 and 3.5 K using the technique of single-molecule spectroscopy (SMS). Based on the data obtained, individual molecules appear to have their own law of delta(T) dependence; further, hysteresis effects have been observed in thermocycling experiments. The single-mo
The effects of energy conservation and saturation are studied in the coordinate space dipole formulation for QCD cascades. Preliminary results for dipole-dipole and dipole-nucleus scattering are presented. Very large effects are obtained from energy conservation, corresponding to a factor similar to 10 in the cross section and similar to 3 in lambda(eff). Some results on the gluon fusion process g
PURPOSE: To determine the relevance of popliteal dilatations, knowledge of the normal popliteal artery diameter is essential. This study investigates the diameter of the popliteal artery in healthy males and females. METHODS: We measured the diameter of the popliteal artery in 121 healthy volunteers (59 males and 62 females), ages 8 to 81, with echo-tracking B-mode ultrasonography. We analyzed the
This licentiate study has been completed as a part of a larger experimental program "Durability of Reinforced Concrete Structures in Marine Environment" carried out in Sweden and Denmark. The aim of this work has been to identify and critically evaluate some major parameters influencing the onset of active reinforcement corrosion in concrete in marine environment. Since the topic is naturally very
The status of instrumentation, control and automation (ICA) within the European wastewater community is reviewed and some major incentives and bottlenecks are defined. Future trends of ICA are also discussed. The information is based on a COST 624 workshop and a non-exhaustive survey with regard to ICA carried out in 13 European countries during March 2001. The level of instrumentation (type of se
The gene encoding calpain-10 (CAPN10) has been identified as a candidate gene for type 2 diabetes. Our aim was to study the impact of genetic (heritability and polymorphisms) and nongenetic (insulin, free fatty acids, and age) factors on CAPN10 mRNA expression in skeletal muscle using two different study designs. Muscle biopsies were obtained before and after hyperinsulinemic-euglycemic clamps fro
Aim of the study. To investigate intrauterine infection as a cause for unexplained stillbirth. Methods. Chorioamnionitis was studied in a material of stillbirths (117 subjects from the years 1985-1994) from a region in the south Sweden. Control material (126 alive and healthy newborns and with healthy mothers) was gathered from the same region. Results. Chorioamnionitis was a common diagnosis bo
Study of anti-Thatcherist tendencies in British cinema of the 1980s.
Increased vascular dilatation and permeability characterize allergic rhinitis. In this study oligonucleotide microarrays (Affymetrix HuGe95A) were used to identify differentially expressed vasoactive genes in nasal biopsies from 23 patients with symptomatic seasonal allergic rhinitis (SAR) and 12 healthy controls. RNA was extracted from the biopsies and pooled in three patient and three control po
The life histories of holo-anhydrobiotic animals differ from those of all other organisms by a regular or irregular entrance into an ametabolic state induced by desiccation. Such ametabolic periods will arrest growth and reproduction completely and thus affect primary life history parameters dramatically. The selective forces and the genetic and physiological trade-offs acting on anhydrobiotic ani
The current ambition to enlarge the European Union (EU) from fifteen to twenty-seven member states has brought to the fore questions about European integration and its overarching aim. On 7 June, 2001, the Irish people decided not to ratify the Nice Treaty. However, the Irish 'no' was not considered to be an expression of political resentment that could impinge on further development of European i
The conjugated polymer poly(2-methoxy-5-(2'-ethylhexyloxy)-1,4-pheiiylene vinylene) (MEH-PPV) was studied by a single-molecule imaging technique. A comparison of statistical distributions of fluorescence intensity with molecular weight distributions revealed that the distribution of the photoluminescence quantum yield of the single polymer chains under study is significantly asymmetric, with a pol
OBJECTIVE--The aim was to investigate associations between exposure to mineral fibres and dust, and cancer in subsites within the large bowel. DESIGN--Pooled retrospective cohort studies. SUBJECTS AND SETTINGS--Blue collar workers, employed for at least one year in different trades; asbestos cement or cement workers (n = 2507), other industrial workers (n = 3965), and fishermen (n = 8092). MAIN OU
