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Numerous obesity loci have been identified using genome-wide association studies. A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci, but replication studies are lacking. Therefore, we tested whether the aggregate effect of these loci is diminished in adults of European ancestry reporting high levels of physical activity. Twelve obesity-susceptibili
AIMS/HYPOTHESIS: The aim of this work was to investigate, in children newly diagnosed with type 1 diabetes: (1) the prevalence of autoantibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb); and (2) the association between TPOAb, TGAb or both, with either islet autoantibodies or HLA-DQ genes. METHODS: Blood samples from 2,433 children newly diagnosed with type 1 diabetes were analys
The role of oxidative stress within photoreceptors (PRs) in inherited photoreceptor degeneration (IPD) is unclear. We investigated this question using four IPD mouse models (Pde6b(rd1/rd1), Pde6b(atrd1/atrd1), Rho(-/-) and Prph2(rds/rds)) and compared the abundance of reduced glutathione (GSH) and the activity of mitochondrial NADH:ubiquinone oxidoreductase (complex I), which is oxidative stress s
Background: Patient safety gained public notoriety following the 1999 report of the Institute of Medicine: To Err is Human – Building a Safer Health System which summarized a culminated decades' worth of research that had so far been largely ignored. The aim of this study was to analyze the report's impact on patient safety research in anesthesiology.Methods: A bibliometric analysis was performed
Background: Interleukin-17 (IL-17) monoclonal antibody drugs have been increasingly significant in the treatment of psoriasis, but it is not clear whether the efficacy is equivalent across ethnicities. Objective: To explore the differences of short-term efficacy of IL-17 inhibitors between Caucasians and Asians. Methods: The pooled log risk ratio (logRR) between the groups was estimated. The meta-
Background: Pediatric asthma remains a public health challenge with enormous impact worldwide. Objective: The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities. Methods: We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma
Desalination can be a cost-effective way to produce fresh water and possibly electricity. The Gaza Strip has had a complex hydro-political situation for many years. Gaza (enclosed area) is bordered by the Mediterranean in the west, by Israel in the north and east and by Egypt in the south. Water and electricity consumption in the Gaza Strip is expected to increase in the future due to the increasi
Obestatin is a gastrointestinal peptide having wide-ranging effects on cell proliferation; however, its mechanism of action remains poorly understood. Thus, the aim of the study was to elucidate the effect of exogenous obestatin on the postnatal structural development of the small intestine. Seven-day-old piglets with an average BW of 1.56 ± 0.23 kg were divided into four groups (n = 10) that rece
Three new genera Coppinsidea, Vandenboomia and Wolseleyidea are described and the genera Ivanpisutia, Lecaniella and Myrionora are resurrected on the basis of a phylogenetic analysisof multi-locus sequence data of the Ramalinaceae including the nuclear protein-codingmarker rpb2, the internal transcribed spacer and a fragment of the small mitochondrialsubunit. The genus Hertelidea was positioned wi
Addressing the biodiversity crisis requires renewed collaborative approaches. Large carnivores are ambassadorspecies, and as such they can aid the protection of a wide range of species, including evolutionarilydistinct and threatened ones, while being popular for conservation marketing. However, conflicts betweencarnivores and people present a considerable challenge to biodiversity conservation. OAddressing the biodiversity crisis requires renewed collaborative approaches. Large carnivores are ambassador species, and as such they can aid the protection of a wide range of species, including evolutionarily distinct and threatened ones, while being popular for conservation marketing. However, conflicts between carnivores and people present a considerable challenge to biodiversity conservation
Introduction: In 2011, a homozygous mutation in GOSR2 (c.430G > T; p. Gly144Trp) was reported as a novel cause of Progressive Myoclonus Epilepsy (PME) with early-onset ataxia. Interestingly, the ancestors of patients originate from countries bound to the North Sea, hence the condition was termed North Sea PME (NSPME). Until now, only 20 patients have been reported in literature. Here, we provide a
In this study, we aim to investigate the possibility that the construction of the Isahaya Sea-Dyke significantly causes anoxic water development in the bottom layer in the Ariake Sea, Japan. We numerically compared the vertical distribution of dissolved oxygen (DO) in the water column between two cases with the dyke and without it. As a result of this research, the followings are clarified: 1) DO
Importance: Novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain tau aggregates in Alzheimer disease. Objective: To determine which plasma biomarker combinations can accurately detect tau pathological brain changes in Down syndrome (DS). Design, Setting, and Participants: The cross-sectional, multicenter Alzheimer's Biomarker Consortium-Down Syndrome study included adul
Temporariness of refugee protection has started to emerge as a new standard in the policies of European countries. Given this development, the article focuses on one specific issue related to this temporariness: how refugee status intertwines with the conditions for the granting, revocation and prolongation of national residence permits. What are the interconnections between refugee status, includ
Migration includes re-starting and re-building a life course. It begins with re-imagination of the journey and the kind of life that is going to take shape in the receiving society. One steps in a migratory journey with knowledge of the past experiences of dealing with risks through, among others, developing an understanding about one’s body. With migration, bodies get displaced, emplaced, replace
The integration of high-precision cellular localization and machine learning (ML) is considered a cornerstone technique in future cellular navigation systems, offering unparalleled accuracy and functionality. This study focuses on localization based on uplink channel measurements in a fifth-generation (5G) new radio (NR) system. An attention-aided ML-based single-snapshot localization pipeline is
The two phases of El-Niño-Southern Oscillation (ENSO) influence both regional and global terrestrial vegetation productivity on inter-annual scales. However, the major drivers for the regional vegetation productivity and their controlling strengths during different phases of ENSO remain unclear. We herein disentangled the impacts of two phases of ENSO on regional carbon cycle using multiple data s
