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On 12 July 2021 the World Health Organization (WHO) Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing published a set of reports entitled Human Genome Editing: A Framework for Governance and Recommendations. These reports provide valuable advice and recommendations on appropriate institutional, national and global governance mechanisms fo
Posttraumatic syringomyelia (PTS) is a serious condition of progressive expansion of spinal cord cysts, affecting patients with spinal cord injury years after injury. To evaluate neural cell therapy to prevent cyst expansion and potentially replace lost neurons, we developed a rat model of PTS. We combined contusive trauma with subarachnoid injections of blood, causing tethering of the spinal cord
INTRODUCTION The closure of a local labor ward enhanced the possibility to initiate a continuity of midwifery care model project. Continuity models of midwifery care are a cornerstone in midwifery and women-centered care, mainly accessible in metropolitan areas. Australian studies have found continuity of midwifery care to work well in rural areas. The aim of this study is to describe midwives’ ex
PURPOSE: To investigate the impact of COVID-19 in Sweden on rates of knee and hip surgeries.METHODS: We used healthcare data for the population of the southernmost region in Sweden (1.4 million inhabitants). We did an interrupted time-series analysis to estimate changes in rates and trends of joint replacements (JR), arthroscopies, and fracture surgeries for knee or hip in April-December 2020 comp
The study investigated the effects of forest residue extraction on tree growth and base cations concentrations in soil waterunder different climatic conditions in Sweden. For this purpose, the dynamic model ForSAFE was used to compare theeffects of whole-tree harvesting and stem harvesting on tree biomass and the soil solution over time at 6 different forestsites. The study confirmed the results f
This research is a case study of the social activism experiences of Ai Xiaoming, a literature professor, feminist, rights activist, and independent documentary filmmaker. The research addresses the broad struggle for recognition and representation of feminists, activists, independent filmmakers, public intellectuals and scholars in digital China. The analysis of her case has led to the creation of
Background: The increased risk of cardiovascular events (CVE) in rheumatoid arthritis (RA) is not fully explained by traditional risk factors. Immuno-inflammatory mechanisms and autoantibodies could be involved in the pathogenesis of atherosclerotic disease. It has been suggested that anti-phosphorylcholine antibodies (anti-PC) of the IgM subclass may have atheroprotective effects. Here, we aimed
In their studies of collective exploitation of common-pool resources, Ostrom and other scholars have stressed the importance of sanctioning as an essential method for preventing overuse and, eventually, the collapse of commons. However, most of the available evidence is based on data covering a relatively small period in history, and thus does not inform us about the evolution of rules, including
Background: Coinfection of malaria and intestinal helminths affects one third of the global population, largely among communities with severe poverty. The spread of these parasitic infections overlays in several epidemiological locations and the host shows different outcomes. This systematic review and meta-analysis determine the pooled prevalence of malaria and intestinal helminthiases coinfectio
The rule of law in the EU is not only substantive and formal, it is also procedural. From the early years of European integration until now – and this through the interpretative lens of either the terse Article 31 ECSC or the robust Article 19 TEU - the procedural rule of law has always been thriving and jolting in the case law of both the European Coal and Steal Community (ECSC) Court and the Cou
The density and modulus of elasticity (MOE) distribution can provide information on the effectiveness of parametric and non-parametric methods in calculating the characteristic value of MOE. In this study, we aim to determine the optimal distribution model of the actual measured data of the lumber. We also estimate the lumber’s MOE characteristic value and compare the difference in density and MOE
Aminoacyl tRNA synthetases are enzymes involved in the key process of coupling an amino acid to its cognate tRNA. AN3365 is a novel antibiotic that specifically targets leucyl-tRNA synthetase, whose development was halted after evaluation in phase II clinical trials owing to the rapid selection of resistance. In an attempt to bring AN3365 back into the developmental pipeline we have evaluated the
MXenes are technologically interesting 2D materials that show potential in numerous applications. The properties of the MXenes depend at large extent on the selection of elements that build the 2D MX-layer. Another key parameter for tuning the attractive material properties is the species that terminate the surfaces of the MX-layers. Although being an important parameter, experimental studies on t
Adipocyte-rich omentum offers “good soil” for disseminating ovarian cancer (OvCa), contributing to therapeutic difficulty. However, little is understood about the association between adipocytes and tumor growth at peritoneal dissemination site. Herein, we report the induction of adipocyte dedifferentiation by OvCa cells and pro-tumorigenic effects of resulted adipocyte-derived fibroblasts. We conf
One aspect rarely addressed in rhetorical analyses of Pauline texts is that the emphasis on rhetorical features tends to exclude dialectical aspects such as the layout of arguments and their soundness. However, these are equally important aspects alongside the rhetorical ones when assessing argumentation from an overall perspective.I suggest that when analysing Paul's argumentation it is useful to
gamma-Trace, a microprotein occurring in neuroendocrine cells, was demonstrated by immunohistochemical technique to be present in the calcitonin-producing C-cells of normal simian thyroid gland and of human medullary thyroid carcinoma. A comparatively high concentration of gamma-trace was demonstrated in tissue extract of neoplastic C-cells. The immunoreactive protein found in the extract had a mo
Many industrially relevant emulsification devices are of the high-energy type, where drop deformation and subsequent breakup, take place due to intense turbulent fluid–drop interactions. This includes high-pressure homogenizers as well as rotor-stator mixers (also known as high-shear mixers) of various designs. The stress acting on a drop in a turbulent flow field varies over time, occasionally re
