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Inhaled corticosteroid (ICS) therapy is central to the long-term management of asthma and is extensively used in the management of chronic obstructive pulmonary disease (COPD). While administration via inhalation limits systemic exposure compared with oral or injected corticosteroids and, therefore, the risk of systemic corticosteroid-related adverse effects, concerns over the long-term safety of
AIMS/HYPOTHESIS: To date, the molecular function of most of the reported type 2 diabetes-associated loci remains unknown. The introduction or removal of cytosine-phosphate-guanine (CpG) dinucleotides, which are possible sites of DNA methylation, has been suggested as a potential mechanism through which single-nucleotide polymorphisms (SNPs) can affect gene function via epigenetics. The aim of this
OBJECTIVE: To establish the diagnostic sensitivity of and the relationships between autoantibodies to all three Zinc transporter 8 (Zinc transporter 8 autoantibody to either one, two, or all three amino acid variants at position 325, ZnT8A) variants to human leukocyte antigen (HLA)-DQ and to autoantibodies to glutamic acid decarboxylase (GADA), insulinoma-associated protein 2 (IA-2A), and insulin
The thesis concerns glycosyl transfer with use of b-glycosidases, most of them from hyperthermophilic organisms. Both optimisation of the reaction conditions and protein engineering in terms of site-directed mutagenesis were used to improve b-glycosidase-catalysed reactions. The first part of the work deals with conversion of lactose into valuable products such as galacto-oligosaccharides (GOS) an
Urban living in built environments, combined with the use of processed water and food, may not provide the microbial stimulation necessary for a balanced development of immune function. Many chronic inflammatory disorders, including allergic, autoimmune, metabolic, and even some behavioural disorders, are linked to alteration in the human commensal microbiota. Sedentary lifestyle is associated wit
Does perfluorooctane sulfonate (PFOS) and perfluorooctanate (PFOA) exposure disrupt the menstrual cyclicity? The female reproductive system may be sensitive to PFOA exposure, with longer menstrual cycle length at higher exposure. PFOS and PFOA are persistent man-made chemicals. Experimental animal studies suggest they are reproductive toxicants but epidemiological findings are inconsistent. A cros
The signaling mechanisms controlling organ damage in the pancreas in severe acute pancreatitis (AP) remain elusive. Herein, we examined the role of farnesyltransferase signaling in AP.
Coeliac disease and type 1 diabetes are autoimmune diseases that may share the same initiating environmental factors. In this study, the occurrence of type 1 diabetes associated autoantibodies (GADA and IA-2A) and tissue transglutaminase autoantibodies (TGA) was determined in patients with confirmed viral infections and no signs of type 1 diabetes or coeliac disease. Serum samples from 82 Cuban pa
A high energy supply and appropriate amount of polyunsaturated fatty acids is crucial for proper growth and development in neonates. The capacity for fatty acid absorption in newborns is however hampered due to an undeveloped pancreatic function combined with a low bile output. This seems in particular to limit fatty acid absorption in babies given infant formulas. Since interaction between the li
Vid en diskussion om nivån på den svenska bolagsskatten är det av stor vikt att avgöra huruvida diskussionen rör den nominella eller den effektiva skattesatsen. Den nominella skattesatsen uppgår till 28 procent och återfinns i 65 kap. 14 § IL. Den effektiva skattesatsen är däremot inte given utan kan i viss utsträckning påverkas, eftersom den bestäms genom att dividera skatt på årets resultat med
Since the mid 90s more focus has been put on the problems surrounding hooliganism, especially in the media. This began when football referee Anders Frisk was injured during a football game. Nowadays, the police use more and more resources to prevent the problems with hooliganism and new laws have been instituted to handle the problem. More and more politicians, football players, coaches, and club
The appearance anxiety phenomenon has become increasingly prevalent in Chinese society, especially among females. This research critically examines the Chinese social media trend “Refusing Appearance Anxiety” (“拒绝容貌焦虑”)initiated by female bloggers who are opposing the issue. The primary goal of this study is to reflect on how Chinese females negotiate with the normative discourse around body image
Title: Motherhood Means Business: a motivational factor in entrepreneurship Seminar date: 1 June 2023 Course: FEKH99, Bachelor Degree Project in Entrepreneurship and Innovation Management, Business administration, 15 University Credit Points Authors: Molly Eklund, Isa Stinger & Stina Svensson Advisor: Ziad El-Awad Keywords: Mother entrepreneurship; motivational factors; Push and Pull theory; O
This thesis analyses how conspiracy narratives are used to negotiate a collective identity within the global branch of the Freedom Convoy movement. To better understand what common conspiracies are present and how they function for the group’s collective identity, this paper is based on empirical data from text messages and memes shared in a group chat on Telegram, an instant messaging platform. W
In the context of China’s concerning decline in fertility rates and the widespread normalization of the ‘996’ overtime culture, the connection between overtime work and fertility assumes considerable importance. This research is firmly grounded in the theoretical framework of the Theory of Planned Behavior (Ajzen, 1991), which investigates the complex relationship between overtime work and fertili
Due to various political and economic crises around the world, the displacement of large populations has constituted one of the most important contemporary social problems; causing social tensions and conflicts between the “newcomers” (Them) and the local community (Us). In this context, media has played an important role in the construction of narratives that, in most cases, present immigrants in
Salinisation is a global issue which leads to desertification and soil degradation and exposure to salt is also known to inhibit microbial activity and plant growth. This study was conducted to determine the influence of salinity on microbial activity of a non- saline soil. By using Salt Induced Community Tolerance (SICT) concept I found that microbial community tolerance to salt can be induced in
