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OBJECTIVES: Patient-reported outcome measures (PROMs) are important for clinical practice and research. Given the high unmet need, our aim was to develop a comprehensive PROM for systemic sclerosis (SSc), jointly with patient experts. METHODS: This European Alliance of Associations for Rheumatology (EULAR)-endorsed project involved 11 European SSc centres. Relevant health dimensions were chosen an

Augmented reality (AR) games are a rich environment for researching and testing computational systems that provide subtle user guidance and training. In particular computer systems that aim to augment a user's situation awareness benefit from the range of sensors and computing power available in AR headsets. The main focus of this work-in-progress paper is the introduction of the concept of the in

Blended and online learning environments continue to grow, transforming higher education. The motivation behind this study is to explore blended and online learning environments, from the perspective of students, through the lens of Activity Theory (AT). Based on 12 virtual semi-structured interviews with Master's (MSc) students at one University in England, the paper sheds light onto some of the

The practice of code review is widely adopted in industry and hasbeen studied to an increasing degree in the research community.However, the developer experience of code review has receivedlimited attention. Here, we report on initial results from a mixed-method exploratory study of the developer experience.

This paper discusses challenges, experiences and lessons learned so far while transforming a masonry build system based mostly on manual labour into a robot automated build system. Our motivation for selection of this masonry process is to try out how robot automation could impact the architects in their design work by providing a tool to directly manipulate wall expression down to individual bric

Cooperative transport allows for the transportation of items too large for the capacity of a single individual. Beyond humans, it is regularly employed by ants and social spiders where two or more individuals, with more or less coordinated movements, transport food to a known destination. In contrast to this, pairs of male and female dung beetles successfully transport brood balls to a location un

Denna studie undersöker konflikten i Taranto, en stad i södra Italien som sedan 1960 talet har hyst ett av Europas största stålverk, Ilva. Under årtiondenas lopp har Ilva omformat Tarantos socioekonomiska och miljömässiga landskap och orsakat allvarlig förorening, som epidemiologiska studier har kopplat till överdödlighet och ökad sjuklighet. Denna kris har lett till en konflikt som också har utkäThis study examines the conflict in Taranto, a city in Southern Italy that has hosted one of Europe’s largest steel plants, Ilva, since the 1960s. Over the decades, Ilva has reshaped Taranto’s socioeconomic and environmental landscape, causing severe pollution that epidemiological studies have linked to excess mortality and morbidity. This crisis has led to a conflict fought also through legal mea

The motion of pre-existing edge dislocations in an infinite linear elastic body is studied. Motion is due to a quasi-statically steady-state growing crack. In the model, the dislocations glide if the force on the dislocation exceeds a critical value. Obtained results are changes in dislocation density, the shielding effect on the crack tip and residual stresses. The model is applied to an isotropi

PURPOSE: Perceived Threat of the Risk of Graft Rejection (PTRGR) is prominent in organ transplant recipients' lives. When asked about what they fear most, the commonest response is graft rejection. A reasonable assumption is that this perceived threat is also relevant for heart recipients and involves various psychological reactions, such as efforts to cope with the perceived threat. There are no

Ambiguity and controversy abounds the debate over the thousands of people trying to enter the European territory and their rights, especially in their procedural form. This paper explores the latest developments in the context of the European Court of Human Rights’ and the European Court of Justice’s expansive interpretation of the right to an effective remedy and the procedural guarantees afforde

The European grapevine moth, Lobesia botrana, uses (E,Z)-7,9-dodecadienyl acetate as its major sex pheromone component. Through in vivo labeling experiments we demonstrated that the doubly unsaturated pheromone component is produced by ∆11 desaturation of tetradecanoic acid, followed by chain shortening of (Z)-11-tetradecenoic acid to (Z)-9-dodecenoic acid, and subsequently introduction of the sec

Neutrophils are highly abundant in synovial fluid of rheumatic inflamed joints. In oligoarticular juvenile idiopathic arthritis (JIA), synovial fluid neutrophils have impaired effector functions and altered phenotype. We hypothesized that these alterations might impact the immunoregulatory interplay between neutrophils and T cells. In this study we analyzed the suppressive effect of neutrophils, i

Event detection and classification algorithms are resilient towards aggressive resource-aware optimisations. In this paper, we leverage this characteristic in the context of smart health monitoring systems. In more detail, we study the attainable benefits resulting from tailoring Support Vector Machine (SVM) inference engines devoted to the detection of epileptic seizures from ECG-derived features