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The ubiquitin-editing enzyme A20 (TNFAIP3) and the deubiquitinase CYLD are central negative regulators of NF-kappa B signaling. Both can act by removing nonproteolytic K63-linked polyubiquitin chains from an overlapping set of signaling molecules. In B cells, A20 deficiency results in hyperactivity, loss of immune homeostasis, inflammation, and autoimmunity. The reported consequences of CYLD defic

Popular Abstract in Swedish När vi äter socker frisätter kroppen hormonet insulin från specifika beta-celler i bukspottskörteln för att förmå muskelceller och fettceller att ta upp sockret från blodet och därmed återställa blodets sockerbalans. Vid övervikt blir dessa vävnader resistenta mot insulinets verkan vilket leder till att sockret stannar kvar i blodet. Detta vill kroppen undvika då en förThere are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. hyperglucagonemia, for the development of beta-cell dysfunction in pre-diabetic mice. We found that i

Learning from incidents is considered a very important source for learning and improving safety in the process industries. However, the effectiveness of learning from reported incidents can often be ques-tioned. Therefore, there is a need to be able to evaluate the effectiveness of learning from incidents, and for that purpose we need methods and tools. In this paper, a method is described for eva

All is a 17-kDa chromosomally encoded outer membrane protein that mediates serum resistance (complement resistance) in the pathogenic Yersiniae (Yersinia pestis, Y. enterocolitica, and Y. pseudotuberculosis). In this article, we demonstrate that Y pseudotuberculosis Ail from strains PB1, 2812/79, and YPIII/pIB1 (serotypes O:1a, O:1b, and O:3, respectively) can bind the inhibitor of the classical a

Abstract—Service Level Agreements (SLA) are considered a good practice not only for IT outsourcing but also for IT management within an organisation. In this paper we study the usage of SLAs in municipal IT management. Municipal IT management traditionally involves a large organisation, often with a low IT maturity, but with high requirements on software quality and information security. In this s

Popular Abstract in Swedish Avhandlingen belyser läsning och läsarbanor i ett livsperspektiv där fyra lärarstudenters berättelser om läsning från barndom till mötet med lärarutbildningen analyseras ur ett sociokulturellt perspektiv. Ur berättelserna om läsning i olika kontexter såsom familj, skola och lärarutbildning framträder ett perspektiv på läsning som en relationell process. I en relationellThe aim of the thesis is to contribute to knowledge about experience and perceptions of reading that students at a school of education have, from early reading experiences in childhood, to the encounter with reading in context of their teacher training. The following overarching questions were asked: What aspects of narratives appear to be significant in the students’ reading trajectories? Which a

The posttranslational modification of proteins has the potential to generate neoepitopes that may subsequently trigger immune responses. The carbamylation of lysine residues to form homocitrulline may be a key mechanism triggering inflammatory responses. We evaluated the role of carbamylation in triggering immune responses and report a new role for this process in the induction of arthritis. Immun

Popular Abstract in Swedish Hjärtkärlsjukdom är den främsta dödsorsaken i västvärlden och den bakomliggande orsaken är oftast ateroskleros. Ateroskleros, eller åderförkalkning, medför att blodkärlens väggar blir tjocka och förlorar sin normala rörlighet på grund av inlagring av fett och bildningen av ett s.k. aterosklerotiskt plack. Vissa kan leva med åderförkalkning ett helt liv utan att märka avAtherosclerosis is a chronic inflammatory disease characterized by the formation of lipid rich plaques in the arterial wall. Rupture of a plaque results in clinical manifestations such myocardial infarction or stroke. Atherosclerosis is a complex disease where both autoimmune responses towards atherosclerosis-related antigens and smooth muscle repair responses play important roles. This thesis con

Osteoarthritis (OA) of the knee can be defined as primary (non-traumatic) or secondary (post-traumatic). Both non-traumatic OA and post-traumatic OA have been described predominantly in the medial compartment of the knee. The objective of this study was to compare the location of structural radiographic changes in non-traumatic OA and post-traumatic OA. A non-traumatic cohort, consisting of 155 pa

Tumor cells often carry mutations in genes that control cell survival, and become resistant to signals that trigger cell death. Yet, some cell death pathways remain intact in tumor cells. If identified, these pathways might be exploited to selectively remove tumor cells. HAMLET (human α-lactalbumin made lethal to tumor cells) is a protein-lipid complex derived from human milk that activates cell d

Objectives: To assess outcomes after a pain rehabilitation programme in terms of occupational performance and satisfaction with occupational performance, and to investigate whether socio-demographic factors and pain-related factors were associated with outcomes at follow-up. Methods: A pre- and post-test study of 555 participants with musculoskeletal pain who completed a pain rehabilitation progra

This study addressed the contribution of ADAMTS13 deficiency to complement activation in thrombotic thrombocytopenic purpura (TTP). Renal tissue and blood samples were available from 12 TTP patients. C3 and C5b-9 deposition were demonstrated in the renal cortex of two TTP patients, by immunofluorescence and immunohistochemistry, respectively. C3 was also demonstrated in the glomeruli of Shiga toxi

Galectins are defined by a conserved beta-galactoside binding site, which has been linked to many of their important functions in e.g. cell adhesion, signaling and intracellular trafficking. Weak adjacent sites may enhance or decrease affinity for natural beta-galactoside containing glycoconjugates, but little is known about the biological role of this modulation of affinity (fine specificity). We

Background Families with parental intellectual disabilities (ID) are likely to need support in achieving a decent family life. In order to accurately plan for such support services, society needs data regarding the occurrence of those parents and their children. The aim of this study was to investigate the 5-year incidence of children born to women with ID in a county in Sweden. Methods Women born

Uniform control and coordination of immigrant children’s vaccination is a critical current problem in the Swe-dish child health safety work. In this paper we discuss the Business Rules (BR) centric and SOA architected digital service VacSam. VacSam incorporates principles of SOA, Business Rules Approach, and Business Pro-cess Management. The incorporation is used for deriving VacSam from a part of

The human pathogen Haemophilus influenzae causes mainly respiratory tract infections such as acute otitis media in children and exacerbations in patients with chronic obstructive pulmonary disease. We recently revealed the crystal structure of H. influenzeae protein E (PE), a multifunctional adhesin that is involved in direct interactions with lung epithelial cells and host proteins. Based upon th

Objective: To investigate how subjective perceptions of everyday occupations, activity level, day centre attendance, social interaction, self-mastery and clinical factors were related to how unemployed people with psychiatric disabilities (PD) envision a future worker role, also controlling for socio-demographic variables. Participants: 175 people with PD; 93 attended a day centre and 82 did not.

The evaluation of the effectiveness of safety installations (such as emergency exits, lighting, etc.) is a key factor to improve the evacuation performance of buildings or transportation systems. In fact, even though an installation is designed to achieve a given design goal, it could happen it does not perform as intended. According to the Theory of Affordances, this could be interpreted in relat

Industrial energy systems involve many components where fluid flow, heat and mass transfer are the important transport processes. For design and development as well as investigation of innovative ideas, computational methods are of vital importance. Since the early pioneering works (by, e.g., the Spalding group) in the 1960s and 1970s, the development has been tremendous and nowadays CFD (computat