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Purpose To evade immunosurveillance many cancers convert tryptophan (Trp) into kynurenine (Kyn), which induces immunotolerance and suppresses immune responses. Elevated Kyn amounts have been found in blood from patients with cutaneous melanoma. This study aimed to investigate whether higher Kyn abundance and lower Trp abundance can be detected on the surface of cutaneous melanoma lesions compared
BACKGROUND: Simple cold storage (CS) is the gold standard for organ preservation. Recently, evidence has been presented suggesting compared with CS hypothermic machine perfusion (HMP) improves the quality and outcome of kidneys for transplantation. Uppsala has used the LifePort Kidney Transporter to preserve deceased donor kidneys. We evaluated our first single-center 52 cases retrospectively.METH
BACKGROUND: The occurrence of migratory takeoff behavior is the essential first step for long-distance migration of insects. However, its characteristics, frequency of occurrence, and the identity of environmental and physiological factors influencing this process remain largely unknown. RESULTS: We investigate the global pest fall armyworm (FAW, Spodoptera frugiperda) as an exemplar species to in
Celiac disease etiopathogenesis requires genetic predisposition and exposure to gluten, yet these factors alone are not sufficient. Larger longitudinal studies are needed to determine the role of time-varying infections and gut microorganisms. The aim was to design a celiac disease case-cohort longitudinal study using The Environmental Determinants of Diabetes in the Young (TEDDY) study. By age 3-
Silver had an emblematic position in the 17th-century Atlantic world. After the Spanish had discovered silver ores in America, the metal’s meaning became symbolic of colonial dominion, of great wealth and providential fortune. Sweden too initiated a colonial project to obtain silver in the mountainous regions of Lapland. Silver-works were founded in order to refine the metal, and the industry borr
BACKGROUND: Children with autism spectrum disorder (ASD) are at increased risk of epilepsy (EP), but distinguishing epileptic seizures from ASD-associated behavior remains a clinical challenge. Although previous studies have reported changes in peripheral immune markers in adults with EP, it remains unclear whether similar immune signatures are present in pediatric patients with both ASD and EP, a
Timely diagnosis of type 1 diabetes (T1D), especially in high-risk populations, is crucial for preventing serious health complications. T1D is a chronic progressive autoimmune disease that has presymptomatic stages that can be identified through the detection of islet autoantibodies. Given that T1D is associated with other autoimmune diseases, having either those diseases or a family history of th
Polyunsaturated fatty acids (PUFA) have been shown to reduce liver fat compared to saturated fat, but effects of a novel “anti-lipogenic” diet replacing carbohydrates with PUFA (LCPUFA) or a low-fat healthy Nordic diet (HND) rich in whole-grains are unknown. The objective of this study was to investigate the effects of these diets, as compared with usual care (UC), on liver fat (primary outcome) a
CT-based radiostereometric analysis (CT-RSA) is a method of measuring implant micromotion using low-dose CT scans. We evaluated the precision, accuracy, and observer reliability of CT-RSA for measuring femoral stem translation in THA in vitro. A cementless femoral stem was implanted in a synthetic femur mounted on a calibrated micrometer platform. Controlled translations were applied along each or
While the so-called “audiobook boom” has yet to reach academic publishing, thegrowing number of students with print disabilities entering higher education isprompting an increase of academic reading materials in audio formats, such asaudiobooks and text-to-speech software. Despite this, little research exists on students’actual use of audiobooks and text-to-speech in their studies, especially amon
Freight transportation security concerns both public and private actors, however, their interests are often misaligned resulting in conflicting pressure and trade-offs. To understand this, a connection of macro and micro perspectives is required, which is enabled by an institutional lens. Furthermore, there is limited empirical knowledge of how policy design and implementation shape operational co
Two scales of gold mining operations, artisanal and small-scale mining (ASM) and large-scale mining, have operated side by side in Ghana for decades. In the past, the two co-existed on the same mineralised land without much contact or conflict, as large-scale mining occurred underground and ASM operated mainly on the surface. With the former's transition from an underground labour-intensive mining
ObjectivesAutoantibodies against tissue transglutaminase (tTG) are serological markers of celiac disease. The aim was to study the applicability of human leukocyte antigen (HLA)-genotyping and tTG autoantibodies in the screening of celiac disease in a longitudinal birth cohort followed to age 15 years.MethodsIncluded were 13,860 HLA-DQ-genotyped children at birth and previously invited to a screen
Tropical forests provide essential ecosystem services, playing a critical role in climate regulation, biodiversity conservation, and regional hydrological cycles while also supporting livelihoods. However, they are increasingly threatened by deforestation and land-use change. Accurate land cover (LC) mapping is vital to monitor these changes, but mapping tropical forests is challenging due to comp
Objective: Low-carbohydrate, high-fat diets under eucaloric conditions are associated with several health-beneficial metabolic effects in humans, particularly in the liver. We recently observed that apolipoprotein A-IV (apoA-IV), a highly abundant apolipoprotein, was among the most upregulated proteins in circulation after six weeks of consuming a high-fat diet in humans. However, the impact of di
The presence of microplastics (MPs) in water represents a current problem for marine life and a future serious issue for human health. This is pushing towards new approaches for the removal of MPs and, hence, their characterization and evaluation, which up to now has represented a limit for tentative procedures for their degradation. Herein, we reported on a new facile, in situ and non-destructive
Public squares are important spaces for social interaction, yet the influence of lighting on people’s experience and social interaction in such spaces after dark is poorly understood. This study examines users’ environmental appraisals and self-reported social interaction in two public squares in Sweden, comparing daylight with electric lighting after dark. The results show that perceived atmosphe
