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Serglycin (SRGN) has been found overexpressed and secreted in glioblastoma (GBM), associated with tumorigenic signaling and poor prognosis. In this study, we aimed to elucidate the involvement of SRGN in the unfolded protein response (UPR), an oncogenic signaling pathway implicated in protein recycling and cell fate. Herein, we developed stably transduced LN-18shSCR GBM cells, expressing high leve
Child abuse, including physical, sexual, or emotional violence or neglect, is a global problem with serious and long-term consequences for children. Even though child abuse is prohibited in Denmark, the estimated number of physically and sexually abused children is relatively high, whereas the annual number of forensically examined children is low. We present the Danish practice and legal foundati
China is promoting the development of “music industry system” in recent years, by publishing policies and regulations that supporting music industry system with funding, clusters, protecting copyrights, and so on, in both national and regional policies like Chengdu. The difference between yearly developing reports of music industry in 2018 and experiences on the ground shows in the growing of the
CT-based radiostereometric analysis (CT-RSA) is a method of measuring implant micromotion using low-dose CT scans. We evaluated the precision, accuracy, and observer reliability of CT-RSA for measuring femoral stem translation in THA in vitro. A cementless femoral stem was implanted in a synthetic femur mounted on a calibrated micrometer platform. Controlled translations were applied along each or
While the so-called “audiobook boom” has yet to reach academic publishing, thegrowing number of students with print disabilities entering higher education isprompting an increase of academic reading materials in audio formats, such asaudiobooks and text-to-speech software. Despite this, little research exists on students’actual use of audiobooks and text-to-speech in their studies, especially amon
BACKGROUND: An increasing incidence of penicillin-resistant Streptococcus pneumoniae (PRP) was detected in Malmo in 1994. OBJECTIVE: To evaluate clonality and factors facilitating the spread of PRP among children in day-care centers (DCCs). METHODS: We used phenotypic and DNA-fingerprinting methods in conjunction with epidemiologic data from the South Swedish Pneumococcal Intervention Project's in
The clinically relevant polyamine analogue N-1,N-11-diethylnorspermine (DENSPM) inhibits cell growth by down-regulating polyamine biosynthesis, up-regulating polyamine catabolism at the level of spermidine/spermine N-1-acetyltransferase (SSAT), and depleting intracellular polyamine pools. Among human melanoma cell lines, the analogue causes rapid apoptosis in SK-MEL-28 cells and a sharp G(1) arres
The prescribing of selective serotonin reuptake inhibitors for adolescents is extensive despite the fact that there are few pharmacokinetic (PK), efficacy, safety, or tolerability studies on this group. This study reports the PK findings from two trials in adolescents treated with citalopram (CIT) in naturalistic clinical settings: one retrospective and one prospective. The aim of our study was to
The rates of oxygen consumption and lactate production in the guinea-pig oviduct were measured together with registration of contractile activity during three phases of the hormonal cycle. In pro-oestrus (high oestrogen, low progesterone levels) and oestrus (time of ovulation, high oestrogen and progesterone) the rate of O2 consumption was higher than in dioestrus (low oestrogen, high progesterone
It is generally difficult to analytically derive models describing the echo attenuation in pulsed gradient spin-echo (PGSE) experiments for even he simplest porous systems that are commonly studied-especially when the gradient pulse (delta) is of finite length compared to the timescale of the diffusion measurement (Delta). Consequently, various levels of approximation are used to evaluate PGSE ex
A clone encoding farnesyl diphosphate synthase (FPPS) was obtained by PCR from a cDNA library made from young leaves of Artemisia annua. A cDNA clone encoding the tobacco epi-aristolochene synthase (eAS) was kindly supplied by J. Chappell (University of Kentucky, Lexington, KY, USA). Two fusions were constructed, i.e. FPPS/eAS and eAS/FPPS. The stop codon of the N-terminal enzyme was removed and r
Background. Antibiotic utilisation varies profoundly among and within countries, and the extent of antibiotic utilisation correlates with the frequency of bacterial resistance, particularly among children. Hence, it is important to assess which factors may influence prescribing. In addition to variations in morbidity, health-care organisation, drug regulatory and supply systems, prescriber's attit
In the beginning of the 1990s, the Tunisian Ministry of Agriculture launched an ambitious program for constructing small hillside reservoirs in the northern and-central region of the country. At present, more than 720 reservoirs have been created. They consist of small compacted earth dams supplied with a, horizontal overflow weir. Due to lack of hydrological data and the area's extreme floods, ho
This overview focusses on the ubiquitous presence of immunohistochemically visible peptidergic nerves with vasodilatory function. The nerve fibres are primarily related to the parasympathetic system (vasoactive intestinal polypeptide or VIP), the sympathetic system including the adrenal medulla (enkephalins) and to the sensory system (substance P as well as calcitonin gene-related peptide, CGRP).
