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The discovery, in 2004, of extracellular traps released by neutrophils has extended our understanding of the mode of action of various innate immune cells. This fascinating discovery demonstrated the extracellular trapping and killing of various pathogens by neutrophils. During the last decade, evidence has accumulated showing that extracellular traps play a crucial role in the defence mechanisms
Focusing on Western tourism behind the Iron Curtain, this chapter introduces the main research questions addressed in the volume: firstly, how and why Eastern Europe became a tourist destination for citizens of the West; secondly, what impact this had on the development of a tourism industry in the Eastern bloc; and thirdly, to what extent the experiences of Western tourists in Eastern Europe infl
The atrioventricular (AV) node plays a central role during atrial fibrillation (AF). We have recently proposed a statistical AV node model defined by parameters characterizing the arrival rate of atrial impulses, the probability of an impulse choosing either one of the dual AV nodal pathways, the refractory periods of the pathways, and the prolongation of refractory periods. All model parameters a
Type 2 diabetes can often be managed by healthier diet and exercise in early stages of the disease, but as it progresses oral medication is needed and later on the patients will require insulin to survive. Vitamin K is a fat soluble vitamin that is a cofactor in gamma-carboxylation and activation of coagulation proteins produced in the liver. There are also extrahepatic proteins named Gla proteins
We propose a technique to generate non-projective word orders in an efficient statistical linearization system. Our approach predicts liftings of edges in an unordered syntactic tree by means of a classifier, and uses a projective algorithm for tree linearization. We obtain statistically significant improvements on six typologically different languages: English, German, Dutch, Danish, Hungarian, a
The SM2RAIN (soil moisture to rain) model has been widely used for rainfall estimation worldwide. However, due to the lack of sufficient ground observation, the SM2RAIN model driven by different passive microwave soil moisture products over the Tibetan Plateau has not been fully validated. In this article, four widely used satellite microwave soil moisture products (including SMAP, ASCAT, SMOS, an
Increasingly fine-grained cloud billing creates incentives to review the software execution footprint in virtual environments. For example, virtual execution environments move towards lower overhead: from virtual machines to containers, unikernels, and serverless cloud computing. However, the execution footprint of security components in virtualized environments has either remained the same or eve
The paper explores tourists’ smartphone-related information behavior on site in light of the concept of “planned serendipity”. The ability to gatherinformation at anytime and anywhere can deeply influence tourists’ behavior,their information needs and the outcomes of their travel plans. In this study, theconcept of planned serendipity is used to suggest that the outcome of travelinformation behavi
Purpose: A preoperative estimate of the risk of malignancy for intraductal papillary mucinous neoplasms (IPMN) is important. The present study carries out an external validation of the Shin score in a European multicenter cohort. Methods: An observational multicenter European study from 2010 to 2015. All consecutive patients undergoing surgery for IPMN at 35 hospitals with histological-confirmed I
This patient case report describes a 45-year old white unmarried man with disability pension due to schizoaffective disorder, diagnosed at the age of 24. He lives in an apartment and has housing support. Retrospectively, the patient displayed prodromal markers of a disorder within the schizophrenia spectrum many years before the onset of frank psychosis, indeed since childhood. Over the years seve
This article outlines a number of new approaches in the history of medicine and medical humanities to the study of medical case histories from a genre-theoretical vantage point. Differentiating between morphological and structuralist concepts of genre, the essay proposes the investigation of similarities and differences among specific series of case histories in order to recover evolving, changing
Along with aptitude, motivation is the primary determiner of learning outcomes in second language (L2) learning. Widely regarded as an activity especially suited to girls, empirical studies from different sociocultural contexts have, with few exceptions, revealed systematic gender differences in L2 motivation. In particular, gender differences are most apparent in relation to establishing an affin
L2 motivation is a relational phenomenon, shaped by teacher responsiveness (Lamb, 2017; Ushioda, 2009). Little, however, is known about the practices in which responsiveness is manifested. Drawing on research from the culturally responsive teaching paradigm (Petrone, 2013), and highlighting the role of empathy and perspective taking (Warren, 2018), the aim of this ethnographic case study of two le
Background: Due to the COVID-19 pandemic, physical visits were replaced by video visits. The aim of this study was to evaluatethe rapid implementation of telehealth video visits in cancer care from the perspectives of patients and healthcare professionals togain knowledge about when physical visits can be replaced by video visits and to identify the improvements needed to optimizecancer care.Mater
Achromobacter is a genus of Gram-negative rods, which can cause persistent airway infections in people with cystic fibrosis (CF). The knowledge about virulence and clinical implications of Achromobacter is still limited, and it is not fully established whether Achromobacter infections contribute to disease progression or if it is a marker of poor lung function. The most commonly reported Achromoba
In mitosis, transcription factors (TFs) and RNA polymerase disperse across the cytoplasm leading to transcriptional silencing, but some TFs are retained on condensed chromatin and mark genomic sites, a mechanism termed mitotic bookmarking. In pluripotent and differentiated cells this mechanism is important for pluripotency maintenance, cell reprogramming and lineage inheritance. However, the role
