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Bisphenol A in human saliva and urine before and after treatment with dental polymer-based restorative materials

The aim of this study was to quantify bisphenol A (BPA) concentrations in saliva and urine before and after treatment with dental polymer-based restorative materials to assess if placement of this material is associated with increased BPA levels in saliva and urine. Twenty individuals in need of at least one dental restoration with polymer-based restorative material were included in this study. Th

Rewetting the hyper-arid Atacama Desert soil reactivates a carbon-starved microbial decomposer community and also triggers archaeal metabolism

Extreme environmental conditions make soils of the hyper-arid Atacama Desert one of the most hostile habitats for life on the planet. During the short intervals of moisture availability that occur, it remains unresolved how soil microorganisms physiologically respond to such dramatic environmental changes. Therefore, we simulated a precipitation event – without (H2O) and with (H2O + C) labile carb

Extracorporeal Membrane Oxygenation: Set-up, Indications, and Complications

Extracorporeal membrane oxygenation (ECMO) occupies an increasingly important position in the clinic for the management of cardiac and/or pulmonary failure. As a rescue therapy, ECMO can support patients following respiratory or cardiac compromise to act as a bridge to recovery, to decision, or to transplant. This chapter reviews briefly the history of ECMO implementation as well as device modes,

Elements of cognition for general intelligence

What can artificial intelligence learn from the cognitive sciences? We review some fundamental aspects of how human cognition works and relate it to different brain structures and their function. A central theme is that cognition is very different from how it is envisioned in classical artificial intelligence which offers a novel path toward intelligent systems that in many ways is both simpler an

Are European clinical trial funders policies on clinical trial registration and reporting improving? A cross-sectional study

Objectives:Assess the extent to which the clinical trial registration and reporting policies of 25 of the world’s largest public and philanthropic medical research funders meet best practice benchmarks as stipulated by the 2017 WHO Joint Statement, and document changes in the policies and monitoring systems of 19 European funders over the past year.Design, Setting, Participants:Cross-sectional stu

A Description of the Yield of Genetic Reinvestigation in Patients with Inherited Retinal Dystrophies and Previous Inconclusive Genetic Testing

In the present era of evolving gene-based therapies for inherited retinal dystrophies (IRDs), it has become increasingly important to verify the genotype in every case, to identify all subjects eligible for treatment. Moreover, combined insight concerning phenotypes and genotypes is crucial for improved understanding of thevisual impairment, prognosis, and inheritance. The objective of this study

Spatio-temporal variability of the earth’s surface temperature and the changes in land user/land cover : implications for sustainable tourism development

Tourism both contributes to environmental change and is, in turn, affected by such change. One area that is of considerable significance is tourism’s contribution to land use change and its subsequent impacts. Land use change, such as tourism urbanization, together with global heating leads to an increase in surface temperature and deterioration in environmental quality and human comfort levels. U

Skin mesenchymal niches maintain and protect AML-initiating stem cells

Leukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report massive AML cell infiltration in the skin in a transplantation-induced MLL-AF9 AML mouse model. These AML cells could regenerate AML after transplantat

Mechanisms Underlying the Specification of Definitive Hematopoiesis

Hematopoietic stem cells (HSCs) maintain blood through self-renewal and differentiation. Although HSC transplantation is the only cure for various blood disorders, generating and maintaining HSCs in vitro remains challenging, partly due to a limited understanding of the cellular and molecular mechanisms underlying human HSC ontogeny. In embryos, definitive HSCs arise from hemogenic endothelium via

Being between life and death—experiences of COVID-19 survivors 12 to 18 months after being treated in intensive care

Purpose: This study aims to explore the experiences of care, psychosocial support, and psychosocial wellbeing among patients treated for COVID-19 in intensive care 12 to 18 months after discharge. Methods: This study used a qualitative approach with a descriptive design. Semi-structured interviews were performed with 20 adult patients treated for COVID-19 12 to 18 months after being discharged fro

Unveiling the Supply Chain Digital Transformation of Small and Medium Enterprises

The global shift to a knowledge-based economy is driven by rapid advancements in information and communication technology (ICT). Within this landscape, digital transformation of supply chains is crucial for enterprises, particularly small and medium-sized businesses (SMEs), seeking to boost performance and efficiency in competitive markets. Despite increased awareness of this importance, there is

IoT based microcontroller operated UV germicide system

With the rise of the COVID-19 pandemic across the globe, people have come to understand the requirement of sanitation. However, other than the personal hygiene, sanitization of all the appliances (like mobile phone, wristwatch, wallet, eye wear, etc.) has become very important. Therefore, the requirement of germicides is being increased to sanitize all the appliances. A few germicides comprise che

Efficacy and acceptability of cognitive-behavioral therapy and serotonin reuptake inhibitors for pediatric obsessive-compulsive disorder: a network meta-analysis

BackgroundCognitive-behavioral therapy (CBT) and serotonin reuptake inhibitors (SRIs) are recommended treatments for pediatric obsessive-compulsive disorder (OCD), but their relative efficacy and acceptability have not been comprehensively examined. Further, it remains unclear whether the efficacy of in-person CBT is conserved when delivered in other formats, such as over telephone/webcam or as In

Structural brain correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study

Sustained attention is important for maintaining cognitive function and autonomy during ageing, yet older people often show reductions in this domain. The role of the underlying neurobiology is not yet well understood, with most neuroimaging studies primarily focused on fMRI. Here, we utilise sMRI to investigate the relationships between age, structural brain volumes and sustained attention perfor

Ultrasound centre frequency shifts as a novel approach for diagnosing giant cell arteritis : Scandinavian Journal of Rheumatology

Objective: Giant cell arteritis (GCA) is a treatable, but potentially sight- and life-threatening form of systemic vasculitis. Prompt and correct diagnosis is therefore important. Temporal artery biopsy (TAB) is the gold standard for diagnosing GCA, but is associated with risks. There is no reliable non-invasive technique for the diagnosis of GCA. Ultrasound centre frequency shift (CFS) is a novel

Assessing Theoretical Research Contributions in CCT

The present manuscript assesses the rhetorical claims made by authors in a selected corpus of CCT articles (2005-2019) in three representative journals. Against the widespread mantras of “theoretical contributions”, it offers a humble, pluralist framework for CCT scholars to shape and develop relevant and impactful research contributions.