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Successful bacterial pathogens produce an array of virulence factors that allow subversion of the immune system and persistence within the host. For example, uropathogenic Escherichia coli strains, such as CFT073, express Toll/IL-1 receptor-containing (TIR-containing) protein C (TcpC), which impairs TLR signaling, thereby suppressing innate immunity in the urinary tract and enhancing persistence i
Introduction Opportunities for leisure activities and physical mobility are important for the ageing population. Therefore, we aim to describe leisure activities outside the home among very old (over 80 years of age) users and non-users of mobility devices in two European countries. Method Survey data on mobility device use, self-rated physical mobility and leisure activities outside the home were
Background: New or increased impairments may develop several decades after an acute poliomyelitis infection. These new symptoms, commonly referred to as late effects of polio (LEoP), are characterised by muscular weakness and fatigue, generalised fatigue, pain at rest or during activities and cold intolerance. Growing older with LEoP may lead to increased activity limitations and participation res
BACKGROUND: Maintaining and improving the quality of prosthetics and orthotics education at the Tanzania Training Centre for Orthopaedic Technologists is essential for the provision of appropriate prosthetics and orthotics services in African countries.OBJECTIVES: To describe how Tanzanian and Malawian graduates' of the Diploma in Orthopaedic Technology perceive their education and how it could be
SenseWear Armband (SW) is a multisensor monitor to assess physical activity and energy expenditure. Its prediction algorithms have been updated periodically. The aim was to validate SW in children, adolescents, and adults. The most recent SW algorithm 5.2 (SW5.2) and the previous version 2.2 (SW2.2) were evaluated for estimation of energy expenditure during semi-structured activities in 35 childre
Human brown fat tumors (hibernomas) display concomitant loss of the tumor suppressor genes MEN1 and AIP. In the present study, we hypothesized that the brown fat phenotype is attributed to these mutations. Accordingly, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumors, loss of
The University of Vermont College of Medicine and the Vermont Lung Center, in collaboration with the NHLBI, Alpha-1 Foundation, American Thoracic Society, European Respiratory Society, International Society for Cell Therapy, and the Pulmonary Fibrosis Foundation, convened a workshop, "Stem Cells and Cell Therapies in Lung Biology and Lung Diseases, " held July 29 to August 1, 2013 at the Universit
To predict ground-borne vibration levels caused by railway traffic, models for estimating the load from the vibration source, as well as the vibration transmission through the ground, are needed. In the present paper, a finite element formulation in a frame of reference following the moving load, is used for modeling a railway slab track. The response of the underlying soil is represented through
Retinal ischemia arises from circulatory failure. As the retinal blood vessels are key organs in circulatory failure, our aim was to study the retinal vasculature separately from the neuroretina to elucidate the role of hypoxia-inducible factor (HIF) 1α and 1β and vascular endothelial growth factor (VEGF) in retinal ischemia. Retinal ischemia was induced in porcine eyes by applying an intraocular
The Swedish legal scholar Tore Strömberg (1912-1993) is often characterized as the last true representative of the Uppsala school of legal thinking.
Objective: Compare caregiver burden, provision of informal care, participation in everyday occupations and life satisfaction of caregivers to people with stroke, who either had received a client-centred, activities of daily living intervention or usual activities of daily living interventions. Design: A multicentre cluster randomized controlled trial in which 16 rehabilitation units were randomly
IL-18 has been implicated in inflammatory bowel disease (IBD), however its role in the regulation of intestinal CD4+ T-cell function remains unclear. Here we show that murine intestinal CD4+ T cells express high levels of IL-18Rα and provide evidence that IL-18Rα expression is induced on these cells subsequent to their entry into the intestinal mucosa. Using the CD45RBhi T-cell transfer colitis mo
Wikipedia has become a reference knowledge source for scores of NLP applications. One of its invaluable features lies in its multilingual nature, where articles on a same entity or concept can have from one to more than 200 different versions. The interlinking of language versions in Wikipedia has undergone a major renewal with the advent of Wikidata, a unified scheme to identify entities and their
In the ancient corpus of Aesopic fables gods and semi-gods from Greek and Roman mythology often appear. Most commonly Zeus is called upon by fable characters such as the donkey, the snake, and the turtle, all of them pleading for a better destiny. Frequent main characters, rather often promoting their own interests in the fable fictions, are also Hera, Herakles, Apollo, and Hermes. The high esteem
The article contains an edition, Swedish translation and study of a fifteenth-century Easter sermon written in Latin at the Birgittine Abbey of Vadstena, in a postil produced for the curate of Björkvik, who, we may presume, used it as a resource when preparing vernacular sermons for his parishioners. The study is not simply an introduction and historical commentary. Rather, it proceeds from the ho
Abstract in German: Der Aufsatz untersucht das Gedicht »Säf, säf, susa« des schwedischen Fin-de-Siècle-Dichters Gustaf Fröding (1860–1911) aus einer Balladenperspektive. Eine textnahe Analyse zeigt, dass eine Reihe sowohl formaler als auch thematischer Besonderheiten in dem mehrfach vertonten Gedicht an das Genre der traditionellen Ballade angelehnt sind. Zugleich fördert die Analyse zutage, wie F
