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Ischemia-reperfusion injury in transplantation remains a significant clinical challenge with regard to both short-term and long-term complications. In this study, we developed a new amphiphilic construct, polyethylene glycol (PEG)-conjugated lipids (PEG-LIPIDs), to be administered ex vivo intra-arterially to procured porcine kidney allografts before reperfusion. The aim was to create a protective
Myeloid cells, such as monocytes, are central in the immune response to infections. However, limited knowledge exists regarding the inflammatory response to Gram-positive anaerobic cocci (GPAC). To explore the ability of GPACs to induce monocyte activation, we compared two GPAC species, Parvimonas micra and Peptoniphilus harei, with E. coli, a major cause of bloodstream infections. We stimulated w
Background: The occupational therapy intervention, Active in My Home (AiMH), puts occupational engagement, participation in society and personal recovery in focus and includes increased staff support. Aims/Objectives: To investigate how the residents experienced the AiMH support, with a focus on their possibilities for engaging in occupations and participating in society after the intervention. Ma
Groundwater in most parts of the world is an important source of agricultural water supply for food production. Soil salinization, however, threatens groundwater quality and may cause irreparable damage to agricultural land. A key to tackling this threat is to analyze the link between agricultural crop water requirements and groundwater quality. This study aimed to investigate salinity effects on
OBJECTIVES: Iron deficiency, anaemia, and menorrhagia - or heavy menstrual bleeding - are interrelated conditions that are highly prevalent and commonly underrecognised in exercising females of reproductive age. This study utilised a screening tool to identify risk factors and symptoms associated with heavy menstrual bleeding, iron deficiency, and anaemia in this population.DESIGN: An observationa
A key challenge in developing sustainable cities is establishing circular infrastructure systems. Decentralised urban water management solutions (DUWMS) are a case in point: Innovative DUWMS that allow recycling the water, heat, energy, or nutrients contained in wastewater locally are currently emerging in cities around the world. These systems could significantly enhance cities’ water resilience
The scope of this presentation is a new methodology to correct conventional NIR data for scattering effects. The technique aims at measuring the absorption coefficient of the samples rather than the total attenuation, measured by conventional NIR spectroscopy. The main advantage of this is that the absorption coefficient is independent of the path length of the light inside the sample, and therefo
Polarization spectroscopy in the mid-infrared (IRPS) has been applied to the detection of acetylene molecules making use of the asymmetric C-H stretching vibration at around 3 μm. The infrared laser pulses were produced through difference frequency generation in a LiNbO3 crystal pumped by a Nd:YAG and dye laser system. By directly probing the ro-vibrational transitions with IRPS, sensit
Atmospheric dispersion represents a relatively overlooked problem in connection with the ultimate quality of ELT images corrected by adaptive optics (AO). The aim of this paper is to evaluate the contribution from atmospheric dispersion to the background level of the point-spread function (PSF). Since proper suppression of this level is important for the prospects for direct exo-planet observation
Optimization of machining processes, such as milling, is essential for industrial efficiency and product quality. To achieve greater efficiency, it is necessary to understand how tools wear down in different conditions in order to anticipate possible undesirable events like sudden breakage or unpredictable degradation. This study focuses on understanding tool wear in dry milling of compacted graph
The world of games is no longer a males-only field of cultural leisure and labor practices. Many women and girls, and other marginalized groups, have taken console controls to heart and hands, embraced a variety of computer games and player modes, design games and participate in e-sports. The industry and academy and governmental policies have attempted to help balance the gender equality of the f
Satellite remote sensing offers global-scale soil moisture (SM) estimation to assess water and energy cycles. However, the coarse resolution of SM products from microwave remote sensing is unsuitable for fine-scale analysis. This study explored spatial downscaling methods to refine the 0.25° ESA CCI SM product to a 1-km resolution, utilizing optical and thermal remote sensing data, including the n
The gut microbiota plays a pivotal role in human life and undergoes dynamic changes throughout the human lifespan, from infancy to old age. During our life, the gut microbiota influences health and disease across life stages. This review summarizes the discussions and presentations from the symposium “Gut microbiota development from infancy to old age” held in collaboration with the Journal of Int
The efficacy of cancer immunotherapy relies on the recruitment and activation of cytotoxic T cell responses against solid tumors by type 1 conventional dendritic cells (cDC1s). However, the generation of cDC1s for cancer immunotherapy faces significant limitations, including poor cell yield, functional heterogeneity, and susceptibility to immunosuppression in the tumor microenvironment (TME). We r
Genetic factors are of importance for the development of primary hypertension (HT). Intrauterine growth retardation, salt sensitivity and insulin resistance are all characteristic features of individuals prone to develop HT. Monogenic forms of hypertension such as Liddle´s syndrome (LS) and Apparent Mineralocorticoid Excess (AME), and hypotension such as Gitelman´s syndrome (GIT) have recently bee
BACKGROUND: Infective endocarditis is associated with higher mortality in elderly patients, but the role of surgery in this group has not been fully evaluated. The aim of this study was to assess outcomes of left-sided infective endocarditis in elderly patients and to determine the influence of surgery on mortality in the elderly. METHODS AND RESULTS: A nationwide retrospective study was performed
Protein lysine acetylation is known to regulate multiple aspects of bacterial metabolism. However, its presence in mycobacterial signal transduction and virulence-associated proteins has not been studied. In this study, analysis of mycobacterial proteins from different cellular fractions indicated dynamic and widespread occurrence of lysine acetylation. Mycobacterium tuberculosis proteins regulati
Aim: Several countries, such as Norway and Sweden, have not implemented universal varicella vaccination. We present data for Norway and Sweden that were generated by a paediatric multi-country Phase III study over a 10-year period. This assessed the efficacy, antibody persistence and safety of two varicella vaccines containing the same Oka strain. Methods: This was an observer-blind, controlled tr
