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Gamification in Politics

Although gamification is a popular term, the concept has rarely been applied to political studies. Therefore, this chapter provides an overview of the key features of gamification and offers an adapted definition of gamification suited to the study of electoral politics. To help illustrate this definition, two examples of gamification from recent campaigns are discussed: the uCampaign mobile appli

Spectral Analysis of Heart Rate Variability in Time-Varying Conditions and in the Presence of Confounding Factors

The tools for spectrally analyzing heart rate variability (HRV) has in recent years grown considerably, with emphasis on the handling of time-varying conditions and confounding factors. Time–frequency analysis holds since long an important position in HRV analysis, however, this technique cannot alone handle a mean heart rate or a respiratory frequency which vary over time. Overlapping

Short-term effects of a computer-based nutritional nursing training program for inpatient hospital care

RATIONALE: This study aimed to explore whether a computer-based training in eating and nutrition for hospital nursing staff can influence the precision in nutritional treatment and care.METHOD: A pre-intervention and post-intervention study was conducted with a cross-sectional design at each time point. The settings were one intervention (IH) and two control hospitals (CH1 and CH2). Hospital inpat

Low Intra-Individual Variation in Mean Platelet Volume Over Time in Systemic Lupus Erythematosus

Platelets have recently emerged as important immune modulators in systemic lupus erythematosus (SLE), in addition to their role in thrombosis and cardiovascular disease. However, studies investigating mean platelet volume (MPV) in SLE are often scarce, conflicting and cross-sectional. In this study, MPV was measured in clinical routine throughout a defined time-period to quantify both individual M

Role of HAMLET and metabolism in treatment and pathogenesis of pneumococci

Antimicrobial resistance (AMR) is one of the principle public health problems in the 21st century, threatening the available treatment strategies for bacterial infections. Here, we present a human protein-lipid complex, HAMLET (human alpha-lactalbumin made lethal to tumor cells) purified from human milk as a potential therapeutic agent which has both tumoricidal and bactericidal activity. HAMLET’s

Early change in specific depression symptoms and later outcome in internet-delivered psychotherapy for depression : A cohort study and cross-lagged network analysis

BACKGROUND: Symptom reduction occurring early in depression treatment is associated with favourable post-treatment outcome, but it is not known how early reduction in specific depression symptoms affect treatment outcome. We aimed to determine the impact of symptom-specific change from pre-treatment to week four during internet-delivered CBT (ICBT) on overall and symptom-specific depression severi

Protein Biomarker Signatures in Precision Diagnostics of Cancer

Early diagnosing and patient individualized biomarker profiling are two key elements for curative interventions within cancer. Detecting cancer, when the tumor is still localized, allows for a more efficient treatment-either through surgery alone or with systemic therapies, treating a naïve and less heterogeneous tumor cell population. Developing tumors consist of complex and stage-dependent genet

Meaning in Life in Late-Stage Parkinson’s Disease : Results from the Care of Late-Stage Parkinsonism Study (CLaSP) in Six European Countries

The Care of Late-Stage Parkinsonism (CLaSP) study is a longitudinal, multicentre, prospective cohort study to assess the needs and provision of care for people with late-stage Parkinson’s disease and their caregivers in six European countries. As a cross-sectional study within the CLaSP study, 509 people with Parkinson’s disease completed the “Schedule-for-Meaning-in-Life-Evaluation” (SMiLE) quest

Decoding Genetic Enigmas in Sarcoma

Sarcomas represent a broad and heterogenous group of rare tumors. For some subtypes, there arepathognomonic genetic alterations available, while for others such alterations remain to be identified.Especially in entities that harbor large numbers of complex genetic changes, much still remains to beunderstood. One such entity is osteosarcoma, the most common primary bone tumor. Although primarilyaff

Forecasting the Value of Vibration-Based Monitoring Information in Structural Integrity Management

Structural deterioration and increasing load demand are two main factors that compromise the serviceability and functioning of civil constructions. The vastity of the bridge portfolio and the few resources available require maintenance optimization to provide the required user safety. In this context, vibration-based monitoring may provide information about the structural performance and support d

Outcomes and performance of the ACURATE neo2 transcatheter heart valve in clinical practice : one-yearresults of the ACURATE neo2 PMCF Study

BACKGROUND: Transcatheter aortic valve implantation is an effective treatment for patients with aortic stenosis; however, complications related to paravalvular leakage (PVL) persist, including increased risk of mortality, cardiovascular mortality, and rehospitalisation. AIMS: We sought to evaluate the clinical outcomes and valve performance at 1 year in patients with severe aortic stenosis treated

The clinical presentation of major depressive disorder in youth with co-occurring obsessive-compulsive disorder

BackgroundMajor depressive disorder (MDD) is common in youth and among the most frequent comorbid disorders in pediatric obsessive-compulsive disorder (OCD), but it is unclear whether the presence of OCD affects the symptom presentation of MDD in youth.MethodsA sample of youth with OCD and MDD (n = 124) and a sample of youth with MDD but no OCD (n = 673) completed the Patient Health Questionnaire

Naturally Occurring IgG Antibodies Provide Innate Protection against Vibrio cholerae Bacteremia by Recognition of the Outer Membrane Protein U

Cholera epidemics are caused by Vibrio cholerae serogroups O1 and O139, whereas strains collectively known as non-O1/non-O139 V. cholerae are found in cases of extraintestinal infections and bacteremia. The mechanisms and factors influencing the occurrence of bacteremia and survival of V. cholerae in normal human serum have remained unclear. We found that naturally occurring IgG recognizing V. cho

Protein Expression Changes in Ovarian Cancer during the Transition from Benign to Malignant.

Epithelial ovarian carcinoma has in general a poor prognosis since the vast majority of tumors are genomically unstable and clinically highly aggressive. This results in rapid progression of malignancy potential while still asymptomatic and thus in late diagnosis. It is therefore of critical importance to develop methods to diagnose epithelial ovarian carcinoma at its earliest developmental stage,

Mycobacteria-infected bystander macrophages trigger maturation of dendritic cells and enhance their ability to mediate HIV transinfection

Synergistic interplay between Mycobacterium tuberculosis (Mtb) and HIV in coinfected ind-ividuals leads to the acceleration of both tuberculosis and HIVdisease. Mtb, as well as HIV, may modulate the function of many immune cells, including DCs. To dissect the bystander impact of Mfs infected with Mtb on DC functionality, we here investigated changes in DC phenotype, cytokine profiles, and HIV-1 tr

Multicenter comparison trial of DNA extraction methods and PCR assays for detection of Chlamydia pneumoniae in endarterectomy specimens

The reported rate of detection of Chlamydia pneumoniae DNA within atherosclerotic lesions by PCR varies between 0 and 100%. In this study, identical sets of coded experimental atheroma samples (n = 15) and spiked controls (n = 5) were analyzed by 16 test methods in nine centers by means of PCR. The positive controls were correctly identified to levels of 1, 0.1, and 0.01 inclusion bodies of C. pne

Sociala utredningar om barn : En rättssociologisk studie av lagstiftningens krav, utredningarnas argumentationer och konsekvenser för den enskilde

Popular Abstract in Swedish Denna avhandling behandlar sociala utredningar om barn. Avhandlingens övergripande syfte är att ur ett kritiskt perspektiv analysera och diskutera hur de rättsligt givna handlingsdirektiven för utredningsförfarandet och det därmed integrerade stöd- och behandlingsarbetet tillämpas i socialtjänstens faktiska utredningsverksamhet, i förhållande till föräldrarna. Frågan bThis thesis is about the social services’ investigations into childrens need of protection and support. The principal purpose is, from a critical perspective, to analyse and discuss how the legally-accorded procedural directives for the execution of an investigation, and therein the integrated support and counselling work, are adapted in the social services’ actual investigation work in relation t