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BACKGROUND:Postural orthostatic tachycardia syndrome (POTS) is a frequently diagnosed cardiovascular disorder after COVID-19 infection. POTS is characterized by the presence of excessive sinus tachycardia on standing without a fall in blood pressure (BP). We investigated the BP profile using 24-hour ambulatory BP monitoring in patients with new-onset POTS after COVID-19 compared with prepandemic p
Schisandrin B (Sch B) is a predominant bioactive lignan from the fruit of a Chinese medicine food homology plant, Schisandra chinensis. Previously, we observed potent anti-tumor effect of Sch-B in colorectal cancer (CRC) and enhanced chemotherapy efficacy with fluorouracil (5-FU). However, their bioavailability and reciprocal interactions under CRC conditions are unclear. In this study, we first c
This study uses an experimental scale-up model together with a high-speed camera setup to quantitatively study the effect of Weber number on the breakup probability, deformation time, breakup time, breakup position, and breakup rate in this geometry in a turbulent jet. Results show an increase in breakup probability and a decrease in deformation and breakup times with increasing Weber number. Brea
This article traces publishing patterns in the Swedish humanities between 1840 and 1880; a period characterized by a new publishing regime yet bridging two dominant publication forms, the dissertation, and the disciplinary journal. Using the prominent historian Wilhelm Erik Svedelius as an entry point, the article charts how scholars in the humanities navigated the publishing landscape in a more d
Background: Patients in palliative care are often treated with antithrombotics, even in the late stages of disease. Clear guidelines regarding deprescribing are lacking. Objective: The aims of this study were to investigate bleeding as a side effect of antithrombotic treatments the last year in life and map the timing of deprescribing. Methods: A retrospective cohort study was performed. All medic
Biocompatibility testing of medical devices is governed by the ISO 10993 series of standards and includes evaluation of skin sensitization potential of the final product. A majority of all medical devices are tested using in vivo methods, largely due to the lack of in vitro methods validated within the applicability domain of solid materials. The GARDskin method for assessment of chemical skin sen
The S-scheme mechanism in photocatalysis offers a promising approach to significantly enhance photoreductive activity. Here, using Bi dots as electronic media, and by changing the amount of added C@CuO on the surface of flower-shaped Bi2MoO6, a diverse range of CBM-x heterojunctions, were synthesized using a multi-step approach that incorporated solvothermal preparation and calcination methods. CB
This paper presents a comprehensive analysis of the operation management of a multi-node community microgrid (MG), emphasizing power flow constraints and the integration of photovoltaic (PV) and battery systems. This study formulates MG operation management as a multi-objective optimal power flow problem, aiming to minimize costs (maximize profits) and emissions simultaneously. The multi-objective
Heart failure is a leading cause of morbidity and mortality1,2. Elevated intracardiac pressures and myocyte stretch in heart failure trigger the release of counter-regulatory natriuretic peptides, which act through their receptor (NPR1) to affect vasodilation, diuresis and natriuresis, lowering venous pressures and relieving venous congestion3–8. Recombinant natriuretic peptide infusions were deve
Background: In 2020, the coronavirus disease 2019 (COVID-19) pandemic caused disruptions in kidney replacement therapy (KRT) services worldwide. The aim of this study was to assess the effect of the COVID-19 pandemic in 2020 on the incidence of KRT, kidney transplantation activity, mortality and prevalence of KRT across Europe. Methods: Patients receiving KRT were included from 17 countries provid
Introduction: The adverse health effects of sugar-sweetened beverage intake are well-established, but the implications of overall added sugar intake remain unclear. We investigated the associations between intake of added sugar and various sugar-sweetened foods and beverages and risk of 7 cardiovascular diseases in 69,705 participants aged 45–83 years (47.2% female) from the Swedish Mammography co
The interest in galectin-3 as a drug target in the cancer and fibrosis space has grown during the past few years with several new classes of compounds being developed. The first orally available galectin-3 inhibitor, GB1211 (h-galectin-3 Kd = 0.025 μM), is currently in phase 2 clinical trials. Due to structural differences between human and mouse galectin-3 a significant reduction in mouse galect
The overall significance of loop motions for enzymatic activity is generally accepted. However, it has largely remained unclear whether and how such motions can control different steps of catalysis. We have studied this problem on the example of the mobile active site β1α1-loop (loop1) of the (βα)8-barrel enzyme HisF, which is the cyclase subunit of imidazole glycerol phosphate synthase. Loop1 var
Increasing evidence suggests that Lewy body disease (LBD) is associated with clinically important cardiac complications, including sick sinus syndrome, atrial fibrillation and sudden cardiac death. The high prevalence of sick sinus syndrome and atrial fibrillation in LBD suggests the presence of disease-related atrial conduction disorders. To explore whether LBD is associated with atrial conductio
BACKGROUND: The endosymbiotic relationship between Wolbachia bacteria and insects has been of interest for many years due to their diverse types of host reproductive phenotypic manipulation and potential role in the host's evolutionary history and population dynamics. Even though infection rates are high in Lepidoptera and specifically in butterflies, and reproductive manipulation is present in th
This article explores the representation of the female image in the visual artwork of generative AI and the gender issues in it, using eight different generative AI systems, ERNIE-ViLG 2.0, Shuhua, and Yihui from China and Nightcafe, Fotor, Jasper Art, DALLE and Deep dream generator from the West, as comparative cases. In this paper, female cyborg is selected as a representative of female images,
Human-induced impacts are increasing pressure on coastal ecosystems, particularly on benthic ecosystems in high-latitude regions. It has become evident that three of the greatest marine environmental challenges related to anthropogenic activity are warming, ocean acidification, and deoxygenation. The effect of these environmental changes on our uncertain future has created a need to understand the
