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The goal of this thesis was to investigate the path-length dependence of jet suppression for jets propagating through a medium known as the quark–gluon plasma (QGP). The QGP is formed in collisions between two lead (Pb) ions, where the overlap region consists of participant nucleons distributed in an approximately elliptical geometry. Simulations of jet quenching in these collisions were performed
The environments of living in temporary accommodation centers for asylum-seeking migrants have prompted many researchers to question the nature of these spaces in relation to the temporal aspect of navigating an asylum application. The physical isolation of the structures, paired with the unique legal restrictions residents must abide by, can be potentially conducive to chronic social exclusion an
Research on video games and sustainability has predominantly focused on game design — examining how serious games, gamification, and narrative design can transmit ecological knowledge or shape sustainability-related behaviour. This design-centred approach, however, treats sustainability as a property to be embedded in the game system and received by players, leaving a theoretical blind spot: it ca
Lipid nanoparticles (LNPs) have emerged as an efficient platform for mRNA delivery, in which ionisable lipids play a central role in intracellular uptake and endosomal escape. In this study, the influence of different ionisable lipids on cellular uptake, endosomal damages and mRNA release kinetics was investigated to identify promising LNP compositions for effective mRNA delivery. Dose-dependent L
The thesis examines how the American Recovery and Reinvestment Act (ARRA) was legitimised during the 111th U.S. Congress. Although ARRA was introduced as a response to the f inancial crisis with the aim of supporting those most affected, scholarship has shown that its benefits were distributed unevenly. Using critical discourse analysis the thesis analyses congressional hearings and house floor de
Natural products are of great interest for a variety of powerful applications that are related to the biological activity of small organic molecules inspired by nature. While the landscape of natural products is structurally abundant, their occurrence in nature is very scarce, posing a challenge to isolate them in quantities required to be studied and used in pharmaceutical application. This work
AbstractBackgroundThe increasing prevalence of obesity has led to a rise in bariatric surgery as an effective intervention for weight loss and associated co-morbidities. However, concerns persist regarding increased alcohol consumption after surgery.ObjectivesTo objectively assess long-term changes in alcohol use after bariatric surgery, we used the highly specific alcohol biomarker phosphatidylet
Who benefited from agricultural commercialization in colonial Africa? Using social tables for three African economies, we identify a small group of rural capitalists who captured disproportionate gains. We demonstrate how their strategies of accumulation varied across contexts and shaped divergent and often unequal development trajectories.
The climate change in northern Europe is not only leading to more extreme weather events but also causing long dry summers. This affects the moisture content of the ground and the vegetation. Causing an increased number of wildfires within Germany posing a risk to the environment, society, and firefighters. Surface fire spread in wildfires can be influenced by several environmental conditions and
Background: Optimal treatment and support in family planning for women with type 1 diabetes (T1D) and follow-up during pregnancy are important, however, there is limited knowledge from the women’s perspective on their considerations of family planning, pregnancy, and motherhood. Objectives: To explore expectations and experiences of family planning, pregnancy, and motherhood among women with T1D.
Sensory traits shape animal lifestyles due to the central role they play in retrieving and processing environmental information. However, being some of the most energetically expensive tissues to build and maintain, ecological demands often modulate investment in these organs. Evidence that ecology shapes the evolution of sensory traits is plenty, but is heavily biased towards vertebrates and has
Non-invasive MRI is widely used to assess and monitor ischemic stroke, yet conventional approaches often lack sensitivity to subtle microstructural changes and struggle to evaluate tissue viability across lesion, penumbra, and distal regions. In this study, frequency dependent diffusion tensor distribution imaging (ωDTD) was combined with clustering of diffusion tensor distributions D(ω) and multi
The aim of this study was to investigate the frequency of p53 alterations in bilateral breast cancer and to evaluate a possible clonal relationship between the paired tumours regarding p53 alteration and other pathobiological variables. Tumours from 34 patients were investigated with immunohistochemistry, single strand conformation polymorphism analysis and DNA-sequence analysis applied to exons 5
In this study, we have investigated the dynamic behavior of colloidal rods within their isotropic phase, employing multispeckle ultrasmall-angle x-ray photon correlation spectroscopy (UA-XPCS) focusing on the understanding of the interplay between structure and dynamics at the nearest-neighbor length scale. While prior research has primarily focused on the structural aspects, our work addresses th
PURPOSE OF REVIEW: This review aims to give an overview of recent advances in the clinical management of children <18 years of age with end-stage pulmonary hypertension refractory to conventional medical therapy.RECENT FINDINGS/SUMMARY: The increased awareness and characterization of pediatric pulmonary vascular disease has amounted more data toward creating an accurate, and comprehensive, risk pr
