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This thesis investigates the EU’s strategic autonomy which refers to the EU’s strive for increased independence without having to rely on other countries in important policy areas. EU strategic autonomy was introduced in 2013 and has become a higher priority due to recent geopolitical changes. The research question is how the EU balances strategic autonomy with their commitments to multilateralism

Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood. Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on P

Background: Smoking is a strong risk factor for the development of Graves’ ophthalmopathy (GO). Immediate early genes (IEGs) are overexpressed in patients with active GO compared to healthy controls. The aim of this study was to study the effects of tobacco smoking and simvastatin on preadipocytes and orbital fibroblasts (OFs) in the adipogenic process. Methods: Cigarette smoke extract (CSE) was g

Owing to the significant societal value of inland water resources, there is a need for cost-effective monitoring of water quality on large scales. We tested the suitability of the recently launched Sentinel-2A to monitor a key water quality parameter, coloured dissolved organic matter (CDOM), in various types of lakes in northern Sweden. Values of a(420)CDOM (CDOM absorption at 420 nm wavelength)

Background: It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF. Methods and Results: In this nationwide study of the Swedish population, patients with AF and t

Autoimmune (type 1) diabetes mellitus is a chronic disease without a cure. It affects primarily young people but may be diagnosed at any age. Strong genetic susceptibility characterizes the most common form of autoimmune diabetes in children younger than 18 years of age. Autoimmune diabetes is generally assumed to be hereditary, although the majority of patients do not have a family history of aut

Carriers of the hydroxysteroid 17-β dehydrogenase 13 (HSD17B13) gene variant (rs72613567:TA) have a reduced risk of NASH and cirrhosis but not steatosis. We determined its effect on liver histology, lipidome, and transcriptome using ultra performance liquid chromatography-mass spectrometry and RNA-seq. In carriers and noncarriers of the gene variant, we also measured pathways of hepatic fatty acid

Quantitative measurements of blood flow based on magnetic resonance imaging (MRI) using conventional multiple spin echo sequences were evalutated in vivo in healthy young volunteers. Blood flow was measured using MRI in the femoral vein. The initial slope of the multiple spin echo decay curve, corrected for the T2 decay of non-flowing blood was used to calculate the blood flow. As a reference, the

In early 2026, the European Union (EU) adopted the Omnibus I proposal to simplify the Corporate Sustainability Reporting Directive (CSRD) by reducing reporting burdens and enhancing competitiveness. However, it has been criticised for weakening sustainability ambitions and increasing uncertainty about future sustainability reporting. This thesis examines how sustainability professionals percei

Title: Developing Talent or Maintaining Control? Course: BUSN49 - Master Thesis Authors: Klara Gaskell-Brown and Lovisa Wiksborg Supervisor: Roland Paulsen Purpose: This study aims to understand how employees and managers make sense of talent management, and with a particular focus on the relationship between organizational structures, managerial practices and employee responsibility for ca

Based on disappointing results of stem cell-based application in clinical trials for patients with critical limb ischemia, we hypothesized that the acidic environment might be the key factor limiting cell survival and function. In the present study, we used microdialysis to determine presence of acidosis and metabolic imbalance in critical ischemia. Moreover, we explored the effect of extracellula

Genomic manipulation of Yersinia ruckeri, a pathogen of salmonid fish species, is essential for understanding bacterial physiology and virulence. Here, we present a protocol for genomic recombineering in Y. ruckeri, a species reluctant to standard genomic engineering, using CRISPR Cas12a coupled with the λ Red system. We describe steps for identifying protospacer guides, preparing repair template

The osteopontin-derived peptide FOL-005 stimulates hair growth. Using ligand-receptor glyco-capture technology we identified neuropilin-1 (NRP-1), a known co-receptor for vascular endothelial growth factor (VEGF) receptors, as the most probable receptor for FOL-005 and the more stable analogue FOL-026. X-ray diffraction and microscale thermophoresis analysis revealed that FOL-026 shares binding si