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Popular Abstract in Swedish När folk frågat mig vad det är egentligen jag håller på med på labbet, brukar jag lite slarvigt svara att jag jobbar med blod. Jag tänkte här lite närmare gå igenom vad det är jag egentligen gjorde på labbet för Er som undrat. Jag har studerat ett protein i blodkoagulationen som heter faktor V (läs 5). För att man ska förstå varför detta protein är viktigt, måste man noThe homologous blood coagulation factors V (FV) and factor VIII (FVIII) are important at sites of vascular injury for the amplification of the clotting cascade. Activated FV (FVa) serves as a cofactor to the enzyme activated factor X (FXa) in the activation of prothrombin. This complex is called the prothrombinase complex. FVIII functions as a cofactor to the enzyme activated factor IX (FIXa) in t

In Proton Exchange Membrane Fuel Cell (PEMFC) systems, an intercooler contributes to proper thermal management of the reactant air into the cathode. However, the structure/performance of it is not clear yet. In this paper, two case studies concerning an intercooler in a 100 kW PEMFC system are carried out. Plate-fin and tube-fin heat exchangers are analyzed as the intercooler, in terms of volume,

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Popular Abstract in Swedish Denna avhandling gäller glibenklamid som är vårt vanligaste läkemedel för oralt bruk i behandlingen av diabetes mellitus, typ 2 (åldersdiabetes). Glibenklamids upptag, fördelning, omsättning och utsöndring har studerats i detalj hos friska människor samt hos patienter med diabetes. Därtill har läkemedlets och dess metaboliters kinetik relaterats till farmako-dynamiska eGlibenclamide (Gb) is the most commonly employed sulphonylurea worldwide for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). There has been uncertainty concerning its pharmacokinetics (PK) and pharmacodynamics (PD). Numerous long-lasting hypoglycemic reactions, which have sometimes been fatal, have been reported and have been difficult to reconsile with an allegedly short elimina

We consider the decoding of LDPC codes in presence of non-Gaussian noise, especially a set of ¿-mixture models. For each of these models, the optimal LLRs are presented. We study the performance degradation due to the use of incorrect LLR in presence of a given noise model. Without modifying the existing LDPC decoder, we propose robust initial LLR which require minimum knowledge about the underly

Ion beam methods are used to analyse material (Ion Beam Analysis, IBA) and to modify the target (Ion Beam Modification of Materials, IBMM). In this thesis, ion beams have been used in various IBA techniques to investigate the surface nanometre structures, and also in an ion beam synthesis (IBS) technique to form thin films and to modify material properties. The work is divided into two main parts:

Popular Abstract in Swedish I slutet av 1800-talet gjordes upptäckten att atomer bara kan ta upp eller sända ut ljus med vissa våglängder. Denna egenskap beror på att elektronerna endast kan befinna sig i ett av flera diskreta energitillstånd. Man säger att elektronerna är kvantiserade. Kvantiseringen är en effekt av att elektronerna i en atom tvingas hålla sig inom en mycket liten volym. Ju mindrIn this thesis, spectroscopic studies of quantum wells (QWs), quantum wires (QWRs) and quantum dots (QDs) in III-V semiconductors are presented. The electronic structure of these low-dimensional structures have been studied by absorption, photocurrent, electroreflectance, photoluminescence (PL), and photoluminescence excitation (PLE) spectroscopy. The band alignment of GaAs pseudomorphically grow

In recent years, language contacts have been considered one of the main causes for language change (Heine and Kuteva 2005, 2006), and this is also the case in English. However, English has gone through a range of contacts including a mutually intelligible language, e.g., Old Norse, and various dialects. In the context of English, French does not form a similar kind of contact, since it was spoken

In order to produce good decisions, an efficient foundation for decision-making has to exist. This article shows the importance of formal as well as informal structures in order to make the decisions within GMES Advisory Council efficient.

Background. It is expected that fuel cells will play a significant role in a future sustainable energy system, due to their high energy efficiency and possibility to use renewable fuels. Fuels, such as biogas, can be produced locally close to the customers. The improvement for fuel cells during the last years has been fast, but the technology is still in the early phases of development, however th

Popular Abstract in Swedish De fettlösliga vitaminerna upptäcktes i början av 1900 talet, och indelas i klasserna A, D, E och K. Brist på vitaminer i kroppen kan leda till svåra sjukdomar som nattblindhet, benskörhet och cancer. Även en överdos kan vara mycket allvarlig, och därför finns det bestämmelser om vilka livsmedel som ska vitaminberikas samt med hur mycket av varje vitamin. Dessutom utförSample clean-up methodologies based on supercritical fluid extraction (SFE) have been developed for determination of fat-soluble vitamins in foods. This thesis focuses on method development, stressing important issues concerning sample pre-treatment, extraction conditions and collection parameters. It was demonstrated that by using SFE followed by saponification and determination using RP-HPLC wit

Social anxiety disorder (social phobia) is a debilitating and common anxiety disorder, with a lifetime prevalence ranging from 6 % to 12 %. The condition has its onset in childhood and early adolescence, affects females more often than males, and if untreated is associated with high risk of developing comorbid anxiety and mood disorders, as well as substance abuse. The increasingly growing body of

Popular Abstract in Swedish I denna avhandling undersöks vilka funktioner cytoskelettproteinet desmin har strukturellt och funktionellt i hjärta och skelettmuskel. Genom att studera funktionen i hjärt- och skelettmuskler i en transgen musmodell, Des-/- som helt saknar proteinet desmin (delarbete I-III), kan vi uppskatta hur viktigt desmin är för muskelkontraktionen. Vi har även studerat hur en mutWe have examined the functional and structural roles of the cytoskeletal protein desmin in cardiac and skeletal muscles using a genetically modified mouse (Des-/-) with the desmin gene ablated. Desmin forms filaments at the Z-disks in the striated muscle sarcomere, have connections to the sarcolemma and most likely align sarcomeres and whole cells. We have shown a decreased contractile function of