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Background & Aims: Gastrin stimulation of the type 2 cholecystokinin (CCK2) receptor results in ECL cell proliferation and histamine secretion. This report describes the effects of targeted disruption of the CCK2 receptor gene on ECL cell morphology and function. Methods: The ECL cells in the oxyntic mucosa of CCK2 receptor-deficient (knockout [KO]) vs. wild-type (WT) mice were investigated by
A digital image analysis technique for crack monitoring using a standard web-camera has been further developed to acquire continuous data sets on crack development in concrete dams. The method is based on an existing robust and straightforward non-contact method for experimental deformation analysis. It allows for the measurement of suspected serious cracks, identified from inspections, through a
The stroma of carcinomas shares several characteristics with inflamed tissues including a distorted vasculature, active angiogenesis and macrophage infiltration. In addition, the tumor interstitial fluid pressure (P-IF) of the stroma is pathologically elevated. We show here that bevacizumab [rhuMab vascular endothelial growth factor (VEGF), Avastin], a monoclonal antibody to VEGF, at a dose of 5 m
It has been reported in earlier in vitro studies that soft tissue trauma and endotoxin-induced shock causes pulmonary platelet trapping (PPT). This paper describes a noninvasive in vivo technique for dynamic studies of PPT in rabbits. Autologous platelets were labeled with 111In and reinfused into the animals. The following day, the rabbits were anesthetized and placed in a supine position under a
Abstract is not available. This is the final, accepted and revised manuscript of this article. Use alternative location to go to the published article. Requires subscription. The original publication is available at springerlink.com.
We study the equations modelling the evolution of electromagnetic fields in chiral media with dispersion. We prove existence and uniqueness of solutions of these equations and provide estimates for the error of the optical response approximation for chiral media.
Hypophosphatasia is an inherited disorder characterized by defective bone mineralization and deficiency of serum and tissue liver/bone/kidney alkaline phosphatase (L/B/K ALP) activity. We report the characterization of ALPL gene mutations in a series of 11 families from various origins affected by perinatal and infantile hypophosphatasia. Sixteen distinct mutations were found, fifteen of them not
BACKGROUND: In ecologic studies, group-level rather than individual-level exposure data are used. When using group-level exposure data, established by sufficiently large samples of individual exposure assessments, the bias of the effect estimate due to sampling errors or random assessment errors at the individual-level is generally negligible. In contrast, systematic assessment errors may produce
Two-pion correlations in roots(NN) = 130 GeV Au+Au collisions at RHIC have been measured over a broad range of pair transverse momentum k(T) by the PHENIX experiment at RHIC. The k(T) dependent transverse radii are similar to results from heavy-ion collisions at roots(NN) = 4.1 , 4.9, and 17.3 GeV, whereas the longitudinal radius increases monotonically with beam energy. The ratio of the outwards
This study investigated to what extent, and under what circumstances, pair collaboration influences the realism in eyewitness confidence in event memory. The participants first saw a short film clip and then confidence rated their answers to questions on its content. A condition (the Individual-Pair condition) where individual effort preceded pair collaboration showed better calibration compared w
Metasedimentary granulites from the central portion of the Belarus-Podlyasie granulite belt were studied with the purpose to reproduce the Paleoproterozoic tectono-thermal evolution in the western part of the East European craton. The regularities identified in the compositional variations in minerals (particularly, garnet), textural relations between minerals, and thermobarometric data point to t
Petite-positivity - the ability to tolerate the loss of mtDNA - was examined after the treatment with ethidium bromide (EB) in over hundred isolates from the Saccharomyces/Kluyveromyces complex. The identity of petite mutants was confirmed by the loss of specific mtDNA DAPI staining patterns. Besides unequivocal petite-positive and petite-negative phenotypes, a few species exhibited temperature se
A three-dimensional (3-D) imaging system for studies of reactive and non-reactive flows is described. It can be used to reveal the topology of turbulent structures and to extract 3-D quantities, such as concentration gradients. Measurements are performed using a high repetition rate laser and detector system in combination with a scanning mirror. In this study, the system is used for laser-induced
The original immunocompetence handicap hypothesis (ICHH) suggested that testosterone has a handicapping effect in males by both promoting the development of sexual signals and suppressing immune function. A modified version, the stress-linked ICHH, has recently proposed that testosterone is immunosuppressive indirectly by increasing production of corticosterone. To test both the original and stres
Aims: To investigate factors associated with health care utilisation in ambulatory diabetes care in relation to complications attributable to diabetes mellitus in an adult diabetic population. Methods: A cross-sectional study; standardised interview, physical examination, and an evaluation of medical records, comprising all known diabetic subjects living in six primary health care districts in sou
When the genome organization of thirty native isolates belonging to a wine-spoilage yeast Dekkera/Brettanomyces bruxellensis, a distant relative of Saccharomyces cerevisiae, was examined, the number of chromosomes varied drastically, from 4 to at least 9. When single gene probes were used in Southern analysis, the corresponding genes usually mapped to at least two chromosomal bands, excluding a si
