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Popular Abstract in Swedish Allt levande består till stor del av proteiner. De bygger upp muskler och hår, transporterar syre i blodet och ser till att kemin i kroppen fungerar som den ska. Men hur tillverkas då dessa proteiner? Jo i alla celler finns ribosomer, proteinfabriker. En bakterieribosom är ungefär 0.02 mikrometer stor. Den är sammansatt av proteiner och RNA-kedjor. RNA utgör den funktioTranslation is a central biological process, that is catalysed by a machinery consisting of RNA and protein. In this thesis three different protein components of the bacterial protein synthesis system have been structurally studied. Ribosome recycling factor (RRF) is essential for the recycling step of the translation cycle, elongation factor SelB is a specialised elongation factor needed for co-t

Popular Abstract in Swedish I en normalt fungerande organism är det en balans mellan cellproliferation, celldifferentiering och celldöd. Olika typer av störningar av denna balansen resulterar i olika typer av sjukdomar. Denna avhandlingen handlar om när det är för lite celldöd och celldifferentiering och ökad cellproliferation. Detta leder till okontrollerad cell proliferering och resulterar i canIn the normal functioning organism, there is a balance between cell proliferation, cell differentiation, and cell death. An imbalance in these processes results in different diseases. This thesis concerns the imbalance where there is too little cell death and cell differentiation with increased cell proliferation. The result is uncontrolled cell proliferation resulting in the development of cancer

This paper deals with geographical and organisational patterns of knowledge flows in the media industry of southern Sweden, an industry that is characterised by a strong ‘symbolic’ knowledge base. Aim is to address the question of the local versus the non-local as the prime arena for knowledge exchange, and to examine the organisational patterns of knowledge sourcing with specific attention paid t

Studies using satellite sensor-derived data as input to models for CO2 exchange show promising results for closed forest stands. There is a need for extending this approach to other land cover types, in order to carry out large-scale monitoring of CO2 exchange. In this study, three years of eddy covariance data from two peatlands in Sweden were averaged for 16-day composite periods and related to

Retailing Retold offers an alternative approach to the analysis of how international retail images are translated across national boundaries. The approach extends the view on image in previous research as an instrument for monitoring the effects of marketing strategies on consumers’ perceptions of the retailer. Instead, it suggests that the usefulness of image resides in its ability to capture the

Scientific knowledge develops in an increasingly fragmentary way. A multitude of scientific disciplines branch out. Curiosity for this development leads into quests for a unifying understanding. To a certain extent, foundational studies provide such unification. There is a tendency, however, also of a fragmentary growth of foundational studies, like in a multitude of disciplinary foundations. We s

Objective. Pancreatic ductal adenocarcinoma is a highly lethal disease and most patients are not eligible for curable resection. Estimation of prognosis is essential in order to provide the best individual treatment for patients with pancreatic adenocarcinoma. Prediction of survival by current methods is limited, therefore the objective of this study was to determine possible prognostic factors id

Capsaicin is used to investigate the role of peripheral sensory nerve fibers. In previous studies of rats treated by injection of capsaicin into the skin of the neck, 'spontaneous' lesions in the head and neck region were observed. In this study, the course of development over time, the regional distribution and the innervation of capsaicin-induced dermal lesions were assessed in young male Spragu

The interactions of sodium dodecyl sulfate (SDS) with chemically cross-linked gels of ethyl(hydroxyethyl) cellulose (EHEC) were studied. Above the so-called critical association concentration (cac), binding of SDS gives rise to an increased swelling of the EHEC gels. The binding of SDS to the gels was measured with flame emission analysis of the sodium ion. The self-diffusion of the surfactant ion

BACKGROUND: Although hepatitis C virus (HCV) infection is recognized as an important causative factor in the development of liver cirrhosis and hepatocellular cancer (HCC), the strength of this correlation has been difficult to confirm in low-prevalence areas. METHODS: Stored serum samples from 987 consecutive (1978-88) patients with chronic liver disease were tested with an enzyme-linked immunoso

This report describes technical improvements to the manufacture of a carbon fibre electrode for the stable and sensitive detection of H2O2 (detection limit at 0.5 mu M). This electrode was also modified through the co-immobilisation of acetylcholinesterase (AChE) and/or choline oxidase (ChOx) in a bovine serum albumin (BSA) membrane for the development of a sensor for in vivo measurements of acety

Alzheimer´s Disease (AD) is a progressive neurodegenerative dementia characterized by the extracellular accumulation of the beta-amyloid (Ab) peptide into plaques and intracellular phosphorylation and accumulation of tau protein into neurofibrillary tangles (NFT). Inflammation due to astrocytic and microglial activation is one of the ongoing processes in the disease giving rise to cytokine product

Observation is made of rapidity-alignment of K+K- and (p) over barp pairs which results from their asymmetric orientation in rapidity, with respect to the direction from primary quark to antiquark. The K+K- and (p) over barp data are consistent with predictions from the fragmentation string model. However, the (p) over barp data strongly disagree with the conventional implementation of the cluster

Alkaline sphingomyelinase (Alk-SMase) and neutral ceramidase (N-CDase) in the intestinal microvillar membrane are responsible for dietary sphingomyelin digestion. The activities of the enzymes require the presence of bile salt, and the enzymes can be released into the gut lumen in active forms by bile salts and trypsin. It is unclear to what extent that the intestinal presence of bile salts is cri

Relative autonomy refers to the space that teachers have or can create to make choices regarding the curriculum of schooling. In order to transform conflicts and to cope with the tensions that arise in time of change, teachers are urged to make constructive use of their relative autonomy. In this paper some of the conflicts and tensions that exist today are discussed in the context of the Swedish

Objective. To study the distensibility and the diameter of the abdominal aorta and the common carotid artery (CCA) in patients with rheumatoid arthritis (RA), and investigate the relation between mechanical properties of these arteries and disease severity. Methods. One hundred and one patients with RA (33 consecutive cases with extra-articular manifestations, and 68 subjects with non-extra-artic

Background: We have previously demonstrated that patients with Crohn's disease ( CD) of long duration have signs of autonomic neuropathy. The aim of this study was to examine whether autonomic neuropathy is an early manifestation of CD, or a sign appearing late in the course. Methods: Twenty patients, median age 40 years, with a short duration of CD were included. Examination of autonomic reflexes