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Background: Having overweight is increasingly recognized as a risk factor for poor breast cancer (BC) outcomes. Previous studies have linked high body mass index (BMI) to an increased risk of recurrence and higher mortality. While most research has focused on patients treated with adjuvant chemotherapy, this study examines the impact of overweight on recurrence-free survival (RFS) in BC patients t
The Neotropical butterfly genus Adelpha Hübner exhibits remarkable species diversity and striking convergence in wing colour patterns potentially explained by mimicry, making it an exceptional model for exploring trait evolution and its relationship with speciation. To date, unresolved phylogenetic relationships hinder a comprehensive understanding of the evolutionary biology of the genus. Using a
High fidelity Large Eddy Simulations (LES) are performed on a non-premixed hydrogen-air annular rotating detonation combustor. The simulations utilize a 22-step hydrogen-air reaction mechanism and an existing flow solver that is optimized for high-speed reacting flows. The selected combustor, designed by the US Air Force Research Laboratory (AFRL), has been extensively studied experimentally acros
House crows, known for their adaptability, thrive in urban settings by exploiting anthropogenic food sources. We explored the feeding dynamics of house crows (Corvus splendens) in the unique high-altitude urban environment of Srinagar, Jammu and Kashmir. Our research, conducted from July 2023 to February 2024, involved comprehensive field observations across diverse urban and semi-natural landscap
Asthma is a heterogeneous chronic respiratory disease affecting millions worldwide, and the prevalence is increasing. Although most patients achieve disease control using mainstay treatment with inhaled corticosteroids and bronchodilators, a subgroup of patients suffers from uncontrolled disease. Developing novel therapeutic strategies for these patients is therefore of great importance. When trea
Two weakly populated rotational bands have been established in Sn106 from the Fe54 (58Ni,2p) reaction at 243 MeV. One of the bands shows evidence of termination. The result is consistent with cranked Nilsson model calculations, which predict band terminations with a smooth and gradual shape change from a prolate collective to an oblate noncollective structure.
The rigid triaxial rotor plus particle model (RTRP) was applied to the nucleus 125Xe in order to determine the value of the γ deformation. Two quantities are very sensitive to the γ deformation: the signature splitting of Yrast levels for negative parity levels (h1 1 2) and the lifetime of the (I= 7 2+, K= 7 2) isomer for positive parity lev els. From the two analyses one obtains the same value fo
The particle-rotor model using strong coupling basis functions is briefly reviewed. Recent developments are discussed. For example, a formalism for odd-odd nuclei (and negative parity states in even nuclei) is presented. With a standard neutron-proton interaction, measured spins and moments of transitional and deformed Ho nuclei are used to extract their main configurations. Total energy calculati
The evidence for ground-state octupole deformation in a region of nuclei around 145Ba is considered, and signatures that might be observed in the deformed single-particle states of odd-mass isotopes are calculated. The measured ground-state spins and electromagnetic moments of 145Cs and 145Ba can be accounted for by single-particle orbitals at the reflection-asymmetric equilibrium shape.
Background: Cancer-associated fibroblasts (CAFs) are the main constituents of the tumor microenvironment. Several studies have delineated CAF heterogeneity in different types of tumors, however, it is still unknown how the distinct CAF transcriptional profiles are established during tumor progression. Methods: We reanalyzed a previously published single-cell RNA-sequencing dataset of MMTV-PyMT tum
Background: The six-minute walk distance (6MWD) is a measure of functional capacity and a frequently used endpoint in clinical trials investigating transthyretin amyloid cardiomyopathy (ATTR-CM). We evaluated the clinical utility of the 6MWD by quantifying the gap between the expected and observed physical performance and estimating its determinants. Methods: Outpatients with wild-type (ATTRwt)-CM
The introduction presents the 27 chapters of the Handbook on Welfare State Reform by international experts, organized in four parts that provide specific theoretical, methodological, policy-related, as well as reform trend-oriented angles. It begins with contributions providing theoretical lenses and policy paradigms central to the study of welfare state reform. The second part offers an overview
Cardiovascular disease is the global number one causeof mortality and morbidity. The majority of cardio vascular diseases are caused by atherosclerosis, a lipid-driven, inflammatory disease of the middle- and large-sized arteries. The disease is characterized by the formation of atherosclerotic plaques throughout the arterial tree. Over the years, insights intohe pathogenesis of atherosclerosis ha
Little is known about how heritage speakers (HS s) and first-generation migrants perceive global accents, including those of their own peers. Our study compares the accent perception of 107 Italian-speaking individuals belonging to three groups: HS s, migrants, and homeland controls. These three groups rated speech samples from second language learners (L2ers), homeland speakers, and other HS s. T
We discuss instrumentalism as a component of the social changes that accompanied the second industrial revolution, following particularly the case of Germany. These changes constituted a departure from the Enlightenment tradition of natural philosophers towards a new approach to knowledge. We claim that instrumentalism cannot be separated from the disciplining of science that produced the sciences
This paper is about simple random walks on $Z^d$, $d \ge 3$, in a random field of traps, the density of which tends to zero at infinity. We distinguish between the quenched problem (when the traps are fixed) and the annealed problem (when the traps are updated each unit of time). Our goal is not only to find a criterion for zero vs. positive probability of survival, but also to show three differen
This study investigated the retention of spatial knowledge in buildings following route-learning training in a virtual reality environment. A total of 121 participants were tested up to three months later on putting waypoints of the route in the correct order and recalling directions at waypoints. Memory accuracy declined over time, consistentwith classic memory theory. Route knowledge was retaine
Throughout the last decades, the social responsibility of corporations has undergone significant changes. From revolving around self-regulation, voluntariness, and soft law, the regulatory landscape has expanded to involve harder demands on corporations, such as mandatory sustainability due diligence. This thesis considers these changes as a hardening of Corporate Social Responsibility (CSR), and
