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Genome-wide characterization of genetic variants of a large population of individuals within the same species is essential to have a deeper insight into its evolutionary history as well as the genotype-phenotype relationship. Population genomic surveys have been performed in multiple yeast species, including the two model organisms, Saccharomyces cerevisiae and Schizosaccharomyces pombe. In this c
BACKGROUND: A substantial proportion of cancer driver genes (CDG) are also cancer predisposition genes. However, the associations between genetic variants in lung CDGs and the susceptibility to lung cancer have rarely been investigated. METHODS: We selected expression-related single-nucleotide polymorphisms (eSNP) and nonsynonymous variants of lung CDGs, and tested their associations with lung can
Background: Maternal anti–human leukocyte antigen (HLA) Class I is commonly detected alongside anti–human platelet antigen (HPA)-1a in fetal and neonatal alloimmune thrombocytopenia (FNAIT). Little is known regarding whether the presence of anti-HLA Class I may exert an additive effect on the risk and severity of FNAIT. Methods and Materials: We reanalyzed samples originally collected as part of a
Female turnip moths (Agrotis segetum) from a laboratory culture inbred for more than 30 generations, and the offspring (first and third generation) from field-collected insects were analyzed individually for acetates and alcohols in the pheromone gland. Quantitative analysis of individual components was performed at the subnanogram level by gas chromatographymass spectrometry (selected ion monitor
Identification of biomarkers associated with protection from developing diabetic complications is a prerequisite for an effective prevention and treatment. The aim of the present study was to identify clinical and plasma metabolite markers associated with freedom from vascular complications in people with very long duration of type 1 diabetes (T1D). Individuals with T1D, who despite having longer
The crystallization rate during selective laser melting (SLM) of bulk metallic glasses (BMG) is a critical factor in maintaining the material's amorphous structure. To increase the understanding of the interplay between the SLM process and the crystallization behavior of BMGs, a numerical model based on the classical nucleation theory has been developed that accounts for the rapid temperature chan
Evacuation models generally tend to make over-simplifications in the representation of human behaviour in fire due to the difficulties to capture its complexity. This work shows how ‘new’ discrete choice model approaches allow overcoming this issue. A description of the existing state-of-the-art of discrete choice models is introduced to highlight the potential of those models. Three case studies
Proinflammatory cytokines stimulate expression of β-secretase, which increases processing of amyloid precursor protein (APP), ultimately leading to the deposition of amyloid beta (Aβ). The N-terminal domain of β-cleaved APP supports Cu/NO-dependent release of heparan sulfate (HS) from the glypican-1 (Gpc-1) proteoglycan. HS is an inhibitor of β-secretase, thereby constituting a regulatory, negativ
The effects of infused glucagon, histamine and vasopressin on blood flow in anesthetized rats with intrahepatic tumors were studied using microspheres labelled with 99Tcm or 51Cr isotopes. Considerable circulatory effects were noted both in central hemodynamic parameters as well as in organ and tissue blood flows. Glucagon infusion increased blood flow in the spleen and small intestine while hepat
Abstract: The β-decay half-life and the delayed neutron emission of 60Ca are studied within a microscopic model, which is based on the Skyrme interaction T45 to construct single-particle and phonon spaces. We observe a redistribution of the Gamow–Teller strength due to the phonon-phonon coupling and the tensor correlations, considered in the model. For 60Sc, the spin-parity of the ground state is
A growing body of consumer culture theory (CCT) research has pointed to the way that places are increasingly conceptualised and commodified as brands and consumption objects (Lichrou et al., 2008; Giovanardi et al., 2018). Research has explored consumers’ experiences with different kinds of spaces and places, including retail settings (e.g. Penaloza, 1998; Kozinets et al., 2004; Maclaran & Bro
Soil microbiome is one of the most heterogeneous biological systems. State-of-the-art molecular approaches such as those based on single-amplified genomes (SAGs) and metagenome assembled-genomes (MAGs) are now improving our capacity for disentailing soil microbial-mediated processes. Here we analyzed publicly available datasets of soil microbial genomes and MAG's reconstructed from the Amazon's tr
RATIONALE: The alarmin S100A9 has been identified as a potential therapeutic target in myocardial infarction. Short-term S100A9 blockade during the inflammatory phase post-myocardial infarction inhibits systemic and cardiac inflammation and improves cardiac function long term. OBJECTIVE: To evaluate the impact of S100A9 blockade on postischemic cardiac repair. METHODS AND RESULTS: We assessed card
The importance of units that influence a large number of other units in a network has become increasingly recognized in the literature. In this paper we propose a new method to detect such pervasive units by basing our analysis on unit-specific residual error variances subject to suitable adjustments due to the multiple testing issues involved. Accordingly, a sequential multiple testing (SMT) proc
A method for the electrochemical synthesis of palladium nanowires, using porous alumina templates with diameters of 25 nm and 40 nm, is presented. Through an electrochemical barrier layer thinning step, pulsed electrodeposition can take place directly into the anodized aluminum; without need for extra removal, pore opening, and metal contact coating steps. A digital oscilloscope is used to record
This article examines how the mediatised context of foreign policy provides new opportunities for political leaders to both frame and project their own leadership role to new audiences. The past ten years have witnessed a sharp rise in political leaders’ use of new social media to communicate on a range of foreign policy issues. We argue that this new media context of foreign policy, combined with
