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More effective treatments are needed for impaired fasting glucose or glucose intolerance, known as prediabetes. Sulforaphane is an isothiocyanate that reduces hepatic gluconeogenesis in individuals with type 2 diabetes and is well tolerated when provided as a broccoli sprout extract (BSE). Here we report a randomized, double-blind, placebo-controlled trial in which drug-naive individuals with pred

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The polymer electrolyte fuel cells are electrochemical devices that can produce electricity, water, and heat through chemical reactions of hydrogen and oxygen. This manuscript focuses on one detailed state of degradation, called as Membrane Chemical Stability and Metrics. The Accelerated Stress Test under study was standardized by the Department of Energy. Recent advancements in the study of degra

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BACKGROUND: Treatment for breast cancer poses major challenges and leads to a variety of side-effects and problems that affect life for a long time. Experiences and symptoms vary, and research indicates a lack of structures for ensuring individualized rehabilitation. This qualitative focus group study aims to explore the experience of women with BC after participating in a complex randomized contr

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Here we report on findings for four rock samples with melt texture found in a gravel pit within a glaciofluvial deposit near the small town of Kitkiöjärvi in northernmost Sweden. The samples are comprised of granitic clasts embedded in a brown fine-grained melt matrix. The samples all contain quartz grains and/or clasts exhibiting multiple sets of planar deformation features oriented parallel to c

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Introduction: The radiology department plays an important role in healthcare settings, facilitating diagnoses using different imaging modalities, including ultrasound. However, this high-tech environment can pose various risks to patients. In this study, we aimed to describe the risk of patient safety incidents, and factors associated with the prevention of risks related to ultrasound examinations

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The European Human Biomonitoring Initiative (HBM4EU) assessed human biomonitoring data on phthalates in children and adolescents, that were sampled between 2014 and 2021, in a harmonised way. These so-called “HBM4EU Aligned Studies” revealed that almost all children and adolescents were exposed to multiple phthalates concurrently. Some phthalates have been shown to act in a dose-additive manner, t

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The difference in arsenic concentration and speciation between benthic (Pteromylaeus bovinus, Myliobatis aquila) and pelagic rays (Pteroplatytrygon violacea) from the northern Adriatic Sea (Gulf of Trieste) in relation to their size (age) was investigated. High arsenic concentrations were found in both groups with tendency of more efficient arsenic accumulation in benthic species, particularly in

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Background: In the Sahel, one of the largest semi-arid areas in the world, pastoral livestock is the main source of protein for the local population. The quantification of herbaceous biomass in the Sahelian rangelands is of major importance since it provides food for the livestock. The main method used to monitor the biomass consists of cutting, drying, and weighting it. However, indirect methods

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Drought is a multifaceted phenomenon driven by both natural climate fluctuations and human activities. Unlike traditional, slow-developing droughts, flash droughts (FDs) emerge suddenly and intensify rapidly, posing significant challenges for natural resource management. The lack of effective tools to quantify FDs exacerbates stakeholders' concerns, particularly due to the risks they pose to water

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Increased global vegetation gross primary productivity (GPP) over the past decades has led to an enhanced terrestrial carbon sink, an important factor in mitigating global warming. However, the global spatiotemporal evolution of GPP trends is still under debate, largely limiting our understanding of the sustainability in terrestrial carbon sink. Here in this study, based on a dozen of long-term gl

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The color of lakes is an essential indicator of the local ecological state, and the corresponding changes can reflect the physical and biochemical processes of lakes. However, worldwide changes in lake color and their drivers remain largely unknown. Here, we analyze the long-term color distributions and changes of 67,579 lakes worldwide from 1984 to 2021 by utilizing 32 million consistent satellit

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Context: The mechanisms underlying bone fragility and increased fracture risk observed in individuals with type 2 diabetes (T2D) are not yet fully elucidated. Previous research has suggested a role for neuropeptides in regulating bone metabolism; however, the contribution of the neuropeptide Neurotensin (NT), which is thoroughly implicated in T2D and cardiovascular disease, has not been investigat

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Denna forskning undersöker professionaliseringen av strategisk kommunikation som undervisningsdisciplin genom att utforska upplevda spänningar inom ämnet. Högre utbildning är ett ”slagfält” för både professioner och blivande professioner, och studien ger en djupare förståelse för de dynamiska spänningar som formar professionaliseringsprocessen inom denna disciplin. Det finns dock begränsad forskniThis research examines the professionalisation of strategic communication as a teaching discipline by exploring perceived tensions within the subject. Higher education is a “battleground” for both professions and would-be professions, and the study offers a deeper understanding of the dynamic tensions shaping the professionalisation process of this discipline. However, there has been limited resea

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Coherent diffractive imaging experiments often collect incomplete datasets containing regions that lack any measurements. These regions can arise because of beamstops, gaps between detectors, or, in tomography experiments, a missing wedge of data due to a limited sample rotation range. We describe practical and effective approaches to mitigate reconstruction artifacts by bringing uniqueness back t

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BackgroundImpulsive-compulsive disorders (ICDs) are commonly acknowledged as side effects of dopaminergic therapy in Parkinson’s disease (PD). While many large-scale studies have focused on prevalences and high-risk treatments, little is known about practical management of ICDs in clinical care and patients’ experiences.ObjectiveTo investigate how ICDs are recognized in clinical PD care, clinical

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Nowadays organisms encounter not only natural challenges from predators but also significant anthropogenic stressors, such as insecticides, which can profoundly disrupt their normal growth and behavior. However, the knowledge on their potential interactions remains largely unknown, particularly regarding how insecticides may affect predator-prey interactions and prey responses across multiple gene

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A model, based on the solution of two coupled diffusion equations to the excitation and emission wavelengths, respectively, was developed to describe the Raman signal in the time domain in a reflectance configuration in a two-layer medium. The accuracy of the model is characterized by comparison with the results of Monte Carlo simulations. This solver can correctly account for the Raman emitters w