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The increasing environmental awareness in today’s society has created a demand for vehicles with less environmental impact. One way to meet the resulting need is to construct hybrid vehicles, hybrid operation which involves a combination of different energy conversion- and storage principles. This project deals with just such a hybrid solution, a parallel hybrid. To construct a competitive solutio
Since the signing of the Treaty on the European Union (TEU) in 1993 the European Union has been base on three "&semicpillars"&semic. The European Community falls under the so-called pillar I. Under the terms of the TEU the two pillars on the Common Foreign and Security Policy (CFSP) and on Justice and Home Affairs (JHA) differ from pillar I for they do not share the institu
The foundation of International Refugee Law was laid down in the early 1950s by the creation of the UNHCR and the Geneva Convention of July 28 1951Relating to the Status of Refugees (hereinafter the Geneva Convention) and its 1967 Protocol Relating to the Status of Refugees. Refugees and asylum seekers are not only protected through the relatively limited refugee law but also through general human
In June 2005 the Commission imposed a &euro&semic60 million fine on AstraZeneca for abusing its dominant position. This was followed in December 2005 by the Discussion Paper on the application of Article 82 EC, issued by the Directorate-General for Competition of the European Commission. This thesis discusses the interpretation of Article 82 EC and does this from the perspective of pharmac
Who benefited from agricultural commercialization in colonial Africa? Using social tables for three African economies, we identify a small group of rural capitalists who captured disproportionate gains. We demonstrate how their strategies of accumulation varied across contexts and shaped divergent and often unequal development trajectories.
The climate change in northern Europe is not only leading to more extreme weather events but also causing long dry summers. This affects the moisture content of the ground and the vegetation. Causing an increased number of wildfires within Germany posing a risk to the environment, society, and firefighters. Surface fire spread in wildfires can be influenced by several environmental conditions and
Sensory traits shape animal lifestyles due to the central role they play in retrieving and processing environmental information. However, being some of the most energetically expensive tissues to build and maintain, ecological demands often modulate investment in these organs. Evidence that ecology shapes the evolution of sensory traits is plenty, but is heavily biased towards vertebrates and has
Non-invasive MRI is widely used to assess and monitor ischemic stroke, yet conventional approaches often lack sensitivity to subtle microstructural changes and struggle to evaluate tissue viability across lesion, penumbra, and distal regions. In this study, frequency dependent diffusion tensor distribution imaging (ωDTD) was combined with clustering of diffusion tensor distributions D(ω) and multi
The aim of this study was to investigate the frequency of p53 alterations in bilateral breast cancer and to evaluate a possible clonal relationship between the paired tumours regarding p53 alteration and other pathobiological variables. Tumours from 34 patients were investigated with immunohistochemistry, single strand conformation polymorphism analysis and DNA-sequence analysis applied to exons 5
In this study, we have investigated the dynamic behavior of colloidal rods within their isotropic phase, employing multispeckle ultrasmall-angle x-ray photon correlation spectroscopy (UA-XPCS) focusing on the understanding of the interplay between structure and dynamics at the nearest-neighbor length scale. While prior research has primarily focused on the structural aspects, our work addresses th
PURPOSE OF REVIEW: This review aims to give an overview of recent advances in the clinical management of children <18 years of age with end-stage pulmonary hypertension refractory to conventional medical therapy.RECENT FINDINGS/SUMMARY: The increased awareness and characterization of pediatric pulmonary vascular disease has amounted more data toward creating an accurate, and comprehensive, risk pr
Wind energy is an important form of clean energy, and its rational utilization represents a crucial solution for mitigating the energy crisis and global warming. In this study, wind energy potential and its long-term changes in the South China Sea (SCS) are evaluated using ERA5 100 m wind data from 1944 to 2023, validated against ASCAT observations. High wind speeds and high wind power density (WP
The proline-rich domain (PRD) of the tumor suppressor p53 plays a central role in modulating conformational dynamics and molecular interactions, yet its intrinsic structural behavior remains incompletely understood. Here, we combine extensive all-atom molecular dynamics simulations with biophysical validation to characterize the conformational ensemble of the p53 PRD. The domain behaves as an intr
In recent years the treatment of cancer with radioactive drugs, here termed molecular radiotherapy (MRT), has emerged to take a place alongside other treatment modalities, particularly non-radioactive drugs (NRDs) and external beam radiotherapy (EBRT). A purpose-built tool was developed within the Python programming environment to review the evolution of clinical trials performed in the first quar
We report on the effect of magnetic impurities on the microscopic superconducting (SC) properties of the kagome-lattice superconductor La(Ru1-xFex)3Si2 using muon spin relaxation/rotation. A strong suppression of the superconducting critical temperature Tc, the SC volume fraction, and the superfluid density was observed. We further find a correlation between the superfluid density and Tc which is
