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BACKGROUND AND PURPOSE: The effect of age on the distribution of morphine and morphine-3-glucuronide (M3G) across the blood-brain barrier (BBB) was studied in a sheep model utilizing intracerebral microdialysis. The effect of neonatal asphyxia on brain drug distribution was also studied.EXPERIMENTAL APPROACH: Microdialysis probes were inserted into the cortex, striatum and blood of 11 lambs (127 g
Objectives To determine the frequency, accrual, attribution and outcome of neuropsychiatric (NP) events and impact on quality of life over 3 years in a large inception cohort of patients with systemic lupus erythematosus (SLE). Methods The study was conducted by the Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months of SLE diagnosis. NP events were identifi
Caveolae are membrane organelles that play roles in glucose and lipid metabolism and in vascular function. Formation of caveolae requires caveolins and cavins. The make-up of caveolae and their density is considered to reflect cell-specific transcriptional control mechanisms for caveolins and cavins, but knowledge regarding regulation of caveolae genes is incomplete. Myocardin (MYOCD) and its rela
Leukotriene A(4) hydrolase (LTA4H) is a key enzyme in the inflammatory process of mammals. It is an epoxide hydrolase and an aminopeptidase of the M1 family of the MA clan of Zn-metallopeptidases. We have solved the crystal structure of LTA4H in complex with N-[3(R)-[(hydroxyamino)carbonyl]-2-benzyl-1-oxopropyl]-L-alanine, a potent inhibitor of several Zn-metalloenzymes, both endopeptidases and am
Precise regulation of β-cell function is crucial for maintaining blood glucose homeostasis. Pax6 is an essential regulator of β-cell-specific factors like insulin and Glut2. Studies in the developing eye suggest that Pax6 interacts with Mitf to regulate pigment cell differentiation. Here, we show that Mitf, like Pax6, is expressed in all pancreatic endocrine cells during mouse postnatal developmen
Gluconobacter oxydans whole cells and membrane fractions in combination with ferrocene mediators were used to study oxidation of ethanol. The efficiency of mediator?enzyme interaction was assessed by the ratio of maximum current to the apparent Michaelis constant (Imax/KM) for saturating mediator concentrations. The bioelectrocatalytic processes were found to be more efficient with membrane fracti
Amplification of 8p12-p11 is relatively common in breast cancer and several genes within the region have been suggested to affect breast tumor progression. The aim of the study was to map the amplified 8p12-p11 region in a large set of breast tumors in an effort to identify the genetic driver and to explore its impact on tumor progression and prognosis. Copy number alterations (CNAs) were mapped i
Background: Cerebral ischemia activates both the innate and the adaptive immune response, the latter being activated within days after the stroke onset and triggered by the recognition of foreign antigens. Methods: In this study we have investigated the phenotype of antigen presenting cells and the levels of associated major histocompatibility complex class II (MHC II) molecules in the postischemi
The purpose of my study is to question the model service marketing triangle and propose an alternative ways of looking at service marketing. The study is based on a deep, qualitative research. In the research of the material an abductive approach has been used. The primary information sources are interviews with project workers, which are being analyzed together with the theoretical background in
In recent years more attention has been given to the rights of the indigenous peoples. Global awareness has been raised concerning the difficult circumstances under which they live. The ILO Convention No 169 and the UN Draft Declaration will serve as foundations for a new relationship between States and their indigenous peoples, promoting a stronger protection against discrimination and violations
This thesis evaluates the conduct of the United Nations High Commissioner for Refugees in relation to a tripartite Memorandum of Understanding with Sweden and Afghanistan, which aims to facilitate voluntary return of Afghan asylum seekers from Sweden to Afghanistan. The Memorandum was concluded in the context of deteriorating security in Afghanistan and the vocal opposition of a community of asylu
Sponges are aquatic filter feeding animals that use internal chambers comprised of choanoflagellate-like cells called choanocytes to pump and filter water. In this study I investigated the behavior of choanocytes in juvenile Amphimedon queenslandica, a coral reef demosponge, when they were fed Photobacterium damselae subsp. damselae compared to when they were maintained in 0.22μm filtered seawater
The masters thesis The particular politics of the home - domestication and parental practices of digital games in everyday life aims at providing a closer look at how games played on phones, consoles or computers are regulated within the everyday of family life. Through semi-structured interviews with nine parents, the author creates understanding for how digital games are not only tied to the mor
This study aims to examine how systemic factors shape the capabilities of a normative actor to project its power through the discourse. By looking into the statements of EU delegations related to shrinking civic space this study will identify patterns and variations in the EU discourse depending on the level of repression in the third country. We will claim that in the countries where civic space
For more than 40 years the case-law of the European Court of Justice has been developing the principle of prohibition of abuse of law in the European Union. However, in the sphere of value-added tax, the principle was invoked by the Court for the first time in 2006 in the landmark case Halifax, creating a tension between this emerging principle and the principle of legal certainty observed and pro
This thesis examines transnational adaptations of television crime drama between the United Kingdom and the United States. This is accomplished by looking at the case of Broadchurch (ITV, 2013), a complex crime drama series that was adapted from Britain into America as Gracepoint (FOX, 2014). The research explores the themes of cultural adaptation, characterization, and sense of place in both seri
This thesis concerns itself with the possibility that parental descriptions of psychological abuse by an intimate partner are viewed as less severe than claims of physical abuse by social workers involved in custody disputes. Swedish parents (N = 32) with experience of custody disputes were asked to write narratives describing incidents of psychological and physical abuse - abuse by their partner
According to a recent report from the Swedish Civil Contingencies Agency, the city of Kristianstad is considered as one of the most vulnerable in Sweden regarding consequences of a flood. Being protected by a barrier system, a failure would most likely have serious impact on the city. As parts of the city are situated below sea level, a heavy rainfall may cause considerable consequences since ther
