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Background: The European ALLTogether protocol for childhood acute lymphoblastic leukemia, initiated in Sweden 2019, introduced earlier asparaginase during induction, dexamethasone instead of prednisone for all patients, and omitted anthracyclines from low-risk induction to reduce treatment-related toxicity. Consolidation-1 was based on the Induction 1B-phase developed by the BFM-group, replacing m
Effective environmental policies for the tropics depend on accurate, representative scientific data. However, there is strong evidence from particular disciplines and regions that existing research is patchily distributed. Here, we show that poor representation of sampling and citation in some biomes and across key environmental gradients from all disciplines for the entire tropics may lead to fla
Urban areas play an important role in attaining the sustainability and energy goals set by municipalities. Despite the often ambitious sustainability visions and goals for new urban areas, there is limited understanding of how these aspirations are integrated into the planning and development process. This paper aims to provide insights into how energy-related visions and goals, in a new district
This study investigates isoprene emissions in a high-latitude Alpine tundra ecosystem, focusing on using near-field remote sensing of surface temperatures, the photochemical reflectance index (PRI) and normalized difference vegetation index (NDVI), and meteorological measurements to model these emissions. Isoprene is a key biogenic volatile organic compound (BVOC) emitted by select plants, which c
Objective: To describe the clinical and ultrasound characteristics of serous and mucinous cystadenomas in the adnexa. Methods: This was a retrospective international multicenter study. Using the International Ovarian Tumor Analysis (IOTA) database, patients with a histological diagnosis of serous or mucinous cystadenoma who had undergone preoperative ultrasound examination between 1999 and 2016 (I
Background: Diversion—patients who sell or share their medication—is a hotly debated but rela-tively unresearched phenomenon. We have investigated the prevalence of self-reported diversion ofmethadone and buprenorphine at OST programs in Sweden. We have also examined if demographic,treatment, and social factors can be associated with an increased risk of diversion. Methods: Structured interviews w
Background: The COVID-19 pandemic accelerated the use of telemedicine, specifically video consultations as they provide healthcare access in challenging situations where face-to-face encounters are not possible. Nevertheless, it remains largely unknown to what extent the organisation of general practice and national digital infrastructures have impacted the uptake and use of video consultations. O
Objective: Primary care is the base in many health care systems, and to identify the most registered diagnoses in primary care is a way to identify the overall health care use and needs in society. We estimated the rates of the 30 most common diagnoses in primary health care and their male to female ratio. Research design and methods: This was a study including inhabitants 18 years and older out o
BackgroundAntibiotics are handled in large amounts at hospitals at many different wards due to the wide range of bacterial infections that are treated. Unnecessary use and occupational exposure to antibiotics should be avoided due to the risk of bacterial resistance development and adverse health effects including skin and respiratory hypersensitivity reactions in persons handling these drugs.Obje
Global warming is expected to transfer carbon from soil organic matter to atmospheric CO 2, with microbial communities playing a crucial role in regulating this exchange. While the immediate impact of temperature on microbial functions is well understood and causes soil carbon losses, the long-term response remains unclear, with losses stabilising over time, reducing the overall effect of chronic
This study explores the online communication strategies of anti-tourism movements to evaluate their potential contributions to place branding—a topic that has received limited scholarly attention. While prior research often views such movements as antagonistic to place branding efforts, we challenge this assumption. Through an analysis of nine movements across five countries, we apply the typology
This article examines forced migrants’ decision-making over time on movement from first country of asylum. Building on 150 in-depth interviews with Syrian refugees (A note on terminology: the term refugee is used colloquially by our participants, other scholars, the legal profession, and international actors to denote most Syrian migrants, yet it often means different things to its users. While ma
This study examines disaster risk perception and communication in Albania, focusing on two districts in the cities of Tirana and Fier and the villages of Novosela and Dajç, all affected by severe flooding in recent years. The research highlights how dimensions of national culture - particularly fatalism and attachment to home and hearth - interact with contextual, psychological, and demographic ch
Genetics as a science has roots in studying phenotypes of relatives, but molecular approaches facilitate direct measurements of genomic variation between individuals. Agricultural and human biomedical research are both emphasizing genotype-based instruments, such as polygenic scores, but unlike in agriculture, there is an emerging consensus that family variables act nearly independently of genotyp
AimTo explore the meaning of lived experiences of women with a hereditary risk of breast cancer who participate in surveillance of their breasts with magnetic resonance imaging.DesignHermeneutic phenomenology.MethodsInterviews on two occasions were made with 14 women in the surveillance programme. The verbatim transcripts were analysed according to van Manen. The analysis was an insightful iterati
Background: Chronic pain in children can significantly impact daily functioning. While interdisciplinary pain rehabilitation is the recommended treatment, it is resource-intensive and limited in availability. Therefore, children with more complex symptoms, classified as High Impact Chronic Pain (HICP), need to be prioritized for interdisciplinary pain rehabilitation. However, HICP in children has
The European land carbon uptake has been heavily impacted by several recent severe droughts, yet quantitative estimates of carbon uptake anomalies are uncertain. Atmospheric CO2 inverse models (AIMs) provide observation-based estimates of the large-scale carbon flux dynamics, but how well they capture drought impacts on the terrestrial carbon uptake is poorly known. Here we assessed the capacity o
Epigenome-wide studies of pancreatic islets provide valuable insights into type 2 diabetes (T2D) but lack methylomes from individual cell types. Here we show changes to alpha and beta cell-specific methylomes and transcriptomes from people with or without T2D, using whole-genome bisulfite sequencing and RNA sequencing. We discover 22,544 differentially methylated regions annotated to 7,975 genes i
The capacity for birds to adjust their breeding time to variation in spring temperature via plasticity is crucial for insectivorous passerines in temperate areas, particularly in a context of climate disruptions. Recent studies suggested that phenological plasticity varies in response to environmental change via urbanization. We investigated the effects of urbanization on laying date, its phenotyp
This thesis explores how young people in Landkreis Harburg, Germany, make sense ofmilitarization and security narratives in their everyday lives, following Russia's full-scaleinvasion of Ukraine in 2022. Drawing on the conceptual frameworks of militarization andbanal militarism, the study examines how military logic becomes embedded in civilian lifethrough both institutional and informal proce
