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Aims/hypothesis: Five clusters based on clinical characteristics have been suggested as diabetes subtypes: one autoimmune and four subtypes of type 2 diabetes. In the current study we replicate and cross-validate these type 2 diabetes clusters in three large cohorts using variables readily measured in the clinic. Methods: In three independent cohorts, in total 15,940 individuals were clustered bas
Cholinergic pesticides, such as the neonicotinoid imidacloprid, are the most important insecticides used for plant protection worldwide. In recent decades, concerns have been raised about side effects on non-target insect species, including altered foraging behavior and navigation. Although pollinators rely on visual cues to forage and navigate their environment, the effects of neonicotinoids on v
Background: We investigated the alarming trend of curable head and neck cancer (HNC) patients forgoing conventional treatment to pursue alternative medicine (AM). Methods: A prospectively maintained database identified HNC patients with ≥12 weeks from diagnosis to treatment initiation between 2012 and 2017. Reasons for delay were categorized and clinical stages and outcomes of AM patients were ass
The standard model of particle physics encapsulates our best current understanding of physics at the smallest scales. A fundamental axiom of this theory is the universality of the couplings of the different generations of leptons to the electroweak gauge bosons. The measurement of the ratio of the decay rate of W bosons to τ leptons and muons, R(τ/μ), constitutes an important test of this axiom. U
Persistence is a reversible and low-frequency phenomenon allowing a subpopulation of a clonal bacterial population to survive antibiotic treatments. Upon removal of the antibiotic, persister cells resume growth and give rise to viable progeny. Type II toxin-antitoxin (TA) systems were assumed to play a key role in the formation of persister cells in Escherichia coli based on the observation that s
Understanding how the composition of organic coatings influences their ability to resist surface damage during use remains a challenge. A relevant potential influence is that of cross-linking density. This parameter is frequently used for tailoring the mechanical properties of organic coatings and it manifests itself in terms of scratch resistance. However, the mechanisms that influence scratch re
Previous studies on metabolic factors and bladder cancer (BC) risk have shown inconsistent results and have commonly not investigated associations separately by sex, smoking, and tumor invasiveness. Among 811,633 participants in six European cohorts, we investigated sex-specific associations between body mass index (BMI), mid-blood pressure (BP, [systolic + diastolic]/2), plasma glucose, triglycer
Background: Parental social characteristics influence the use of emergency departments (ED) in the USA, but less is known about paediatric ED care-seeking in countries with national health insurance. This prospective study was designed to evaluate associations between parental care-seeking and social characteristics, with emphasis on impact of non-native origin, at a paediatric ED in Sweden, a Eur
FinEstBeAMS is a new materials science beamline at the 1.5 GeV storage ring of the MAX IV Laboratory in Lund, Sweden. It has been built based on grazing incidence monochromatization of synchrotron light, which allows to cover a remarkably wide excitation energy range from ultraviolet to soft x-rays (4.5–1450 eV). A new mobile luminescence spectroscopy end station has been commissioned with design
This article explores the dynamics of state control and specific workings of state power by ethnographically examining the ways in which Chinese grassroots labor NGOs negotiate and gauge the unclear parameters permitted by the Chinese state in South China. By closely examining the everyday activism at the margins of the Chinese state, I argue that the uncertainty about the limits of the state’s to
Although Scandinavia is arguably peripheral in the global literary system, it nevertheless holds a surprisingly prominent position in the field of translation, Swedish and Danish being among the ten most translated languages in the world (Lindqvist, 2015). What literature is selected for translation and introduction into new linguistic contexts is not a coincidence, but has to do with economic fac
A genetic risk score (GRS) based on 29 single nucleotide polymorpysms (SNPs) associated with high blood pressure (BP) was prospectively associated with development of hypertension, stroke and cardiovascular events. The aim of the present study was to evaluate the impact of this GRS on the incidence of aortic disease, including aortic dissection (AD), rupture or surgery of a thoracic (TAA) or abdom
G protein-coupled receptor 30 (GPR30) is a G protein-coupled receptor (GPCR) that is attracting considerable attention in breast cancer and cardiometabolic regulation. Following reports that GPR30 is required for some rapid estrogen responses, e.g. increased cAMP production and ERK1/2 activity, in estrogen receptor (ER)-negative cells, GPR30 was renamed G protein-coupled estrogen receptor 1 (GPER1
The four main findings about the age and abundance structure of the Milky Way bulge based on microlensed dwarf and subgiant stars are: (1) a wide metallicity distribution with distinct peaks at [Fe/H] = -1.09, -0.63, -0.20, +0.12, +0.41; (2) a high fraction of intermediate-age to young stars where at [Fe/H] > 0 more than 35 % are younger than 8 Gyr, (3) several episodes of significant star formati
Case studies of two Swedish municipalities indicate that the general energy area was divided into three independent policy areas: One dealing with supply, one with conservation and one with environmental questions related to the Agenda 21 vision of an ecologically sustainable energy system. However, the dominant energy policy area in the municipalities was supply policy. This article discusses why
Background: The signal transducer and activator of transcription 3 (STAT3) pathway is observed to be constitutively activated in several malignancies including prostate cancer (PCa). In the present study, we investigated the expression of total STAT3 (tSTAT3) and two forms of activated phosphorylated STAT3 (pSTAT3
Buildings are responsible for a third of global greenhouse gas emissions, with much of their life cycle impacts resulting from embodied impacts of building materials. One solution to reduce embodied emissions is to use of secondary materials such as by-products and waste materials for producing building materials (in this study referred to as reuse solutions). While this is reported to have positi
The title compound forms as biphasic single crystals containing the α- and β-polymorphs. The structure of both polymorphs was solved and refined from single crystal X-ray data in a simultaneous refinement. The structures consist of rods of composition Sb3O4 separated by isolated iodine ions. The two phases differ only in the next nearest neighbour arrangement. The orthorhombic α-phase crystallizes
