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It is well known that antipsychotic drugs (APDs) are more effective in reducing symptoms in women than in men, and that women are more sensitive to the side effects of APDs. Therefore, it is of great importance that sex differences in drug responses are considered already in the early stages of drug development. In this study, we investigated whether sex-specific differences could be observed in r

Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous proble

The atmosphere, ocean, and sea ice components in Earth system models are coupled via boundary conditions at the sea surface. Standard coupling algorithms correspond to the first step of an iteration, so-called Schwarz waveform relaxation. Not iterating is computationally cheap but introduces a numerical coupling error, which we aim to quantify for the case of a coupled single column model: the EC-

Introduction: Residual cognitive deficits are commonly reported by individuals in remission from depression, often affecting daily life functioning and mental health. To provide tailored and personalized cognitive enhancement interventions for this population, there is a need for a better understanding of the characteristics of those who benefit from such interventions. Therefore, this study aimed

Pulmonary arterial hypertension (PAH) is a life-threatening condition with no cure, making research into its underlying mechanisms critical. The platelet-derived growth factor (PDGF) signaling pathway plays a crucial role in vascular remodeling, a key factor in PAH progression. Anti-PDGF receptor therapies, such as imatinib, show promise but are associated with significant side effects. Recent res

African Swine Fever (ASF) has been posing a significant threat to pig production and wildlife management in the Republic of Serbia since its first detection in 2019. The goal of this study is to provide a comprehensive overview of the spatial and temporal spread of ASF in both domestic and wild pig populations in Serbia from the initial outbreak in the summer of 2019 through May 2025. Additionally

In the Swiss canton of Geneva, an energy efficiency portfolio has been operated since 2009. In contrast, such programs have been in place for more than 40 years in the US. There are numerous lessons to be learnt from their experience. We have therefore conducted a comparative analysis including Geneva and 11 leading states in the US, with the objective to identify explanatory factors for the succe

Sweden is renowned for its centralised wage bargaining system, which has been studied from the point of view of inflation, wage differentials and unemployment. This article studies media coverage of wage bargaining rounds in the 1950s–1960s and in the 2000s–2010s to investigate the social understanding of what the wage bargaining institutions are supposed to do. The results indicate that the opera

Background: Research on the primary care management of back pain in children and young people (CYP) is scarce. Sociodemographic factors may influence presentation and management, potentially contributing to disparities in care and outcomes. This study aimed to describe the management of back pain in CYP and examine associations with sociodemographic characteristics. Methods: Data were extracted fr

The demand for safe and durable modified-wood products is increasing in the construction sector. In this work, the in situ wet-chemistry synthesis of a glassy MgO/Na2O–SiO2 solid in Scots pine (Pinus sylvestris L.) sapwood via a two-stage impregnation process using an industrial timber-impregnation autoclave is reported. Magnesium sulphate heptahydrate (MgSO4·7H2O), a historic fire retardant, and

BACKGROUND AND OBJECTIVES: Subjective cognitive decline (SCD) is a well-recognized risk state for developing mild cognitive impairment (MCI) and dementia. Optimal risk stratification for early interventions and clinical trial selection remains challenging. This study evaluates progression risk across multimodal biomarker profiles in SCD.METHODS: We conducted a longitudinal observational study incl

AIMS: To investigate the prevalence of diastolic dysfunction and associated risk factors in pre-diabetes and diabetes in the general population.METHODS: Diastolic function was assessed by transthoracic echocardiography in a cross-sectional sample of 3840 men and women aged 50-64 years from the Swedish CArdioPulmonary bioImage Study. Anthropometry, medical history, blood pressure, biochemistry and

Postural orthostatic tachycardia syndrome (POTS) is associated with multiple autonomic symptoms, including gastrointestinal (GI) complaints, and has been linked to insulin resistance. We aimed to explore HbA1c, circulating metabolic hormones (insulin, C-peptide, GIP, GLP-1, glucagon, leptin, and peptide YY) and cortisol, and their associations with hemodynamic parameters and GI symptoms in POTS. T

This thesis analyses the political implications of core traditional humanitarian principles of neutrality, impartiality and independence. With the end of the cold war the phenomena of ?new conflicts? have largely replaced traditional inter-state wars, hence the context of humanitarian emergency situations are no longer the same. Based on case studies of two humanitarian emergency relief operations

The London congestion charging scheme has been in place since the 17th of February 2003 and there is little doubt that, so far, the objectives set out prior to the introduction of the charge have been achieved. The purpose of this paper is to examine the effect the congestion charge have had on the air quality in central London. This was done by studying daily data on a number of pollutants that c

The atmosphere, ocean, and sea ice components in Earth system models are coupled via boundary conditions at the sea surface. Standard coupling algorithms correspond to the first step of an iteration, so-called Schwarz waveform relaxation. Not iterating is computationally cheap but introduces a numerical coupling error, which we aim to quantify for the case of a coupled single column model: the EC-