Filtyp
Microtubule nucleation requires the γ-tubulin ring complex, and during the M phase (mitosis) this complex accumulates at the centrosome to support mitotic spindle formation. The post-translational modification of γ-tubulin through ubiquitination is vital for regulating microtubule nucleation and centrosome duplication. Blocking the BRCA1/BARD1-dependent ubiquitination of γ-tubulin causes centrosom
Along with chronic neurotoxic effects, the long-term consumption of amphetamines has been associated to psychiatric symptoms and memory disturbances. Dendritic spine dynamics have been discussed as a possible morphological correlate. However, the underlying mechanisms are still elusive. 3,4-Methylenedioxyamphetamine (MDA), a major drug of abuse and a main metabolite after 3,4-methylenedioxymethamp
Magnetic compass orientation in a night-migratory songbird requires that Cluster N, a cluster of forebrain regions, is functional. Cluster N, which receives input from the eyes via the thalamofugal pathway, shows high neuronal activity in night-migrants performing magnetic compass-guided behaviour at night, whereas no activation is observed during the day, and covering up the birds' eyes strongly
The emotional salience of faces has previously been shown to induce memory distortions in recognition memory tasks. This event-related potential (ERP) study used repeated runs of a continuous recognition task with emotional and neutral faces to investigate emotion-induced memory distortions. In the second and third runs, participants made more false alarms to distracters (repeated from previous ru
Objective To test a life-course model of cognitive reserve in dementia and examine if school grades around age 10 years, formal educational attainment, and lifetime occupational complexity affect the risk of dementia in old age. Methods 7,574 men and women from the Uppsala Birth Cohort Multigenerational Study were followed for 21 years. Information on school performance, formal education, and occ
An important component of the aircraft generated noise, especially ahead of it, is the fan noise created by the high velocity variation near the blades and the interaction of the rotating fan with the fluid. In order to predict the sound, the method used involves the acoustical analogy developed by Ffowcs Williams and Hawkings. Computation of the flow field is performed in the incompressible LES f
Popular Abstract in Swedish Selen är ett essentiellt näringsämne som behövs för att upprätthålla flera viktiga funktioner i kroppen, huvudsakligen genom en speciell grupp proteiner som heter selenoproteiner. Det finns minst 25 stycken olika selenoproteiner i människan och flera av dem skyddar kroppen mot oxidation medan vissa andra sköter regleringen av sköldkörtelhormoner. Många selenoproteiners Selenium is a micronutrient that is essential for many important life processes due to the action of the specific selenoproteins containing one or more of the 21st amino acid, selenocysteine. Twenty-five selenoprotein genes have been found in the human genome but the function of many of them is not yet known. Some of the characterised selenoproteins have, however, antioxidant properties. Selenium
A Low Weber water spray subjected to an air cross flow has been investigated. The spray is characterized by low liquid injection velocity, producing a column that is broken up by aerodynamic forces from the oncoming air.PIV and PDA have been used to quantify both the continuous and dispersed phases. Long range microscopy has been used to characterize the column breakup process. It has been shown t
Popular Abstract in Swedish Det är idag viktigt att ha tillgång till moderna, snabba och miljövänliga analysmetoder, som är användbara för olika typer av livsmedel. Dagens metoder är arbetskrävande och leder till hantering och konsumtion av stora mängder lösningsmedel. Metoderna är oftast mycket svåra att automatisera på grund av att de innehåller vätske/vätske-extraktionssteg. Ett alternativ tillSample preparation is the most time-consuming step in an analysis. Traditional sample preparation techniques consume large amounts of organic solvents, are time-consuming and are difficult to automate. During the last decade some new extraction techniques have been developed for sample preparation and one of them is supercritical fluid extraction (SFE). This thesis focuses on sample preparation fo
