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Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disease characterized by excessive extracellular matrix deposition. Current IPF therapies slow disease progression but do not stop or reverse it. The (myo)fibroblasts are thought to be the main cellular contributors to excessive extracellular matrix production in IPF. Here we show that fibrotic alveolar type II cells regulate producti
The current study presents a comprehensive research on the design, optimization, and numerical analysis of axial turbines, addressing the urgent need for more efficient and environmentally friendly energy conversion systems. With turbines being central to power generation, aviation, and marine propulsion, enhancing their performance is crucial to reducing fuel consumption, operational costs, and g
This thesis discusses the use of standards in land-use planning risk management regulations. Based on exploring the domains of standards and standardisation, risk science, and risk management regulations, the research contributes significant empirical evidence capturing the perspectives of risk managementpractitioners in terms of the strengths, the weaknesses and the effects of using standards in
In the present work, the concept of mechanically activated annealing (MAA) has been applied to produce nanocrystalline Al0.3CoCrFeNi high-entropy alloys (HEAs) with reduced contamination levels. Phase evolution during conventional mechanical alloying (MA), MAA and subsequent consolidation by spark plasma sintering (SPS) have been studied in detail. Complete alloying is obtained after 15 h of MA, w
The rotational behavior of T=0 and T=1 bands in the odd-odd N=Z nucleus 62Ga is studied theoretically using the spherical shell model (laboratory frame) and the cranked Nilsson-Strutinsky model (intrinsic frame). Both models give a good description of available experimental data. The role of isoscalar and isovector pairing in the T=0 and T=1 bands as functions of angular momentum is studied in the
Two excited superdeformed bands in Gd149 have been observed in -ray spectroscopy. Based on the behavior of the dynamical moments of inertia, we assign one band to a neutron excitation and the other to a proton excitation. The proton-excited-band -ray energies are nearly identical to those already known in Tb150. In addition, two new members of the Gd149 yrast cascade have been observed, extending
The cranked Nilsson-Strutinsky formalism is applied to the many-faceted spectrum of 16O. The deformation parameters ε{lunate}, γ and ε4 are varied independently and many-particle-many-hole excitations are considered in the rotating system. Potential-energy surfaces are presented at different values of spin, parity and signature. Surprisingly good agreement is obtained when the different minima are
Aims: To explore the association between soluble neuropilin-1 (sNRP-1) and depression in patients with newly diagnosed type 2 diabetes (T2D). Materials and Methods: Multicentre, cross-sectional study including adults with serologically confirmed newly diagnosed T2D. Included variables: sex, sNPR-1 (low sNRP-1 was defined as <226 ng/mL), psychometrically assessed depression and anxiety, antidepress
Music and Performing Arts is one of the fields Georgia can pride itself on internationally. While the country is in transition as it officially embarks on its long path to the European Union membership, this study explores the process of Europeanization of Higher Music Education in Georgia. Authors analyze how Higher Music Educational Institutions employ European projects for organizational change
Abstract: Serial dependence (SD) refers to the influence of a recent stimulus on a person’s perceptual judgement of a current stimulus. SD has been found to arise for a wide variety of objects and features, including faces. Perceptual and mnemonic processes, along with response and decisional biases, are thought to contribute to SD effects. Here, two experimental studies are reported examining the
BACKGROUND: Previous studies have demonstrated an association between transplantation rate per center and postoperative mortality after heart transplantation. In 2011, Sweden centralized heart transplants and waiting lists, reducing the number of centers from 3 to 2. We aimed to assess the active waiting time and pre- and post-transplant mortality before and after centralization.METHODS: Heart tra
New particle formation (NPF) events substantially contribute to the number concentration of atmospheric particles and cloud condensation nuclei (CCN) which can further influence radiative balance and Earth's climate. Many short-term studies have found that sulfuric acid (H2 SO4) and highly oxygenated organic molecules (HOM) are critical compounds in the early steps of NPF. However, it is not fully
Photoreceptor oil droplets (ODs) are spherical organelles placed most commonly within the inner segment of the cone photoreceptors. Comprising neutral lipids, ODs can be either non-pigmented or pigmented and have been considered optically functional in various studies. Among living amphibians, ODs were only reported to occur in frogs and toads (Anura), while they are absent in salamanders and caec
Simultaneous digital breast tomosynthesis and mechanical imaging (DBTMI), a novel screening approach, combines anatomic DBT with functional analysis of the stress distribution on the compressed breast by mechanical imaging (MI). Preliminary studies suggest potential to reduce false positive findings. DBTMI requires to align DBT and MI images. In this study, we have analyzed robustness to alignment
This chapter explores, through the lens of the history and development of the situation of statelessness across the Middle East and North Africa (MENA) – a consequence of nation-state formation, state succession and/or discriminatory ethnic, religious and gender law and policy – the striking commonalities in both the causes and consequences of statelessness. It focuses on how the MENA region lacks
The paper is part of a wider research project which seeks to explore the nexus between statelessness and refugee-ness at global, national and individual level. The relationship between the two legal concepts has not received much attention. This is surprising given that one in ten refugees globally are believed to be stateless. To begin to unpack this relationship, Denmark and Sweden are used as c
BACKGROUND: In response to the Institute of Medicine (IOM) report, Dying in America, we undertook an institution wide effort to improve the experience of patients and families facing serious illness by engaging leadership and developing a program to promote the practice of generalist palliative care.MEASURES: The impact of the program was measured with process measures related to its' three parts.
