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We study a network of three populations of coupled phase oscillators with identical frequencies. The populations interact nonlocally, in the sense that all oscillators are coupled to one another, but more weakly to those in neighboring populations than to those in their own population. Using this system as a model system, we discuss for the first time the influence of network topology on the exist
New therapeutic agents for haemophilia with inhibitors that are in development or already licensed are expected to provide transformative treatment options. Many of these new therapies are not based on simply replacing the missing factor; new strategies include bispecific antibody technology that mimics factor VIII coagulation function (emicizumab), and inhibition of anticoagulant proteins such as
Autonomic computing systems adapt themselves thousands of times a second, to accomplish their goal despite changing environmental conditions and demands. The literature reports many decision mechanisms, but in most realizations a single one is applied. This paper compares some state-of-the-art decision making approaches, applied to a self-optimizing autonomic system that allocates resources to a s
Testing of autonomous systems is extremely important as many of them are both safety-critical and security-critical. The architecture and mechanism of such systems are fundamentally different from traditional control software, which appears to operate in more structured environments and are explicitly instructed according to the system design and implementation. To gain a better understanding of a
High expression of Junctional Adhesion Molecule-A (JAM-A) has been linked with poor prognosis in several cancers, including breast cancers overexpressing the human epidermal growth factor receptor-2 (HER2). Furthermore, JAM-A expression has been linked with regulating that of HER2, and associated with the development of resistance to HER2-targeted therapies in breast cancer patients. The purpose o
Differences in immune function between species could be a result of interspecific divergence in coding sequence and/or expression of immune genes. Here, we investigate how the degree of divergence in coding sequence and expression differs between functional categories of immune genes, and if differences between categories occur independently of other factors (expression level, pleiotropy). To this
Over the last two decades, electrification has gained importance as a means to decarbonise the transport sector. As the number of Electric Vehicles (EVs) increases, it is important to consider broader system aspects as well, especially when deciding the type, coverage, size and location of the charging infrastructure required. This article proposes a new approach using agent-based simulations to a
Angle-resolved electrons from laser-Assisted photoionization from atoms are simulated using Time-Dependent Configuration-Interaction Singles. The distributions are interpreted using a propensity rule for transitions in the continuum.
Background: The characteristics of Parkinson's disease (PD) include postural instability and resting tremor. However, reductions of tremor amplitude do not always improve postural stability. Research question: What is the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on spectral analysis of body movement in patients with PD when tested without anti-PD medication? The effe
The benefits of related variety on regional employment growth have become a prevailing view. However, these remain potential benefits unless channels (e.g. labour flows, inter-firm cooperation) and regional capabilities are in place to convert them into actual growth. This paper focuses on the labour mobility channel and proposes a way to measure the realized part of related variety. It demonstrat
Background: [18F]-fluorodeoxyglucose (FDG) positron emission tomography with computed tomography (PET-CT) is a well-established modality in the work-up of patients with suspected or confirmed diagnosis of lung cancer. Recent research efforts have focused on extracting theragnostic and textural information from manually indicated lung lesions. Both semi-automatic and fully automatic use of artifici
In this section of the European Resuscitation Council Guidelines 2021, key information on the epidemiology and outcome of in and out of hospital cardiac arrest are presented. Key contributions from the European Registry of Cardiac Arrest (EuReCa) collaboration are highlighted. Recommendations are presented to enable health systems to develop registries as a platform for quality improvement and to
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To determine the effects of methylxanthine administration on the incidence of apnea and longer-term clinical outcomes in preterm infants including infants at risk for or having apnea and preterm infants peri-extubation.
Disasters are typically conceptualised as extreme events that disrupt the “normal” functioning of a society. Dominant framings imply temporal boundedness and nature as primarily responsible for environmental disasters. Yet, many critical investigations into the root causes of disasters have taken aim at their eventfulness and naturalness through convincing analysis of the historical construction o
OBJECTIVE Degenerative cervical spondylotic myelopathy (CSM) is a major cause of spinal cord dysfunction with an unpredictable prognosis. Βiomarkers reflecting pathophysiological processes in CSM have been insufficiently investigated. It was hypothesized that preoperative cerebrospinal fluid (CSF) biomarker levels are altered in patients with CSM and correlate with neurological status and outcome.
Biomass, as a renewable energy source, is available worldwide, is carbon neutral, and can be converted to various types of products depending on the market and on the specific applications. Among different technologies of biomass utilization, thermochemical conversion of biomass is the most efficient method with the shortest time scale of the process. Thermochemical conversion can be used to produ
This thesis uses discourse to analyze how different story-lines of hydropower development in the Mekong River Basin reproduce the concept of sustainable development. With actors advocating sometimes diametrically opposite development paths resulting in different social, economic and environmental trade-offs they all refer to and motivate their agendas in terms of sustainable development. I applied
