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The adipokine resistin is suggested to be an important link between obesity and insulin resistance. In the present study, we assessed the impact of resistin as inflammatogenic cytokine in the setting of arthritis. In vitro experiments on human PBMC were performed to assess cytokine response and transcription pathways of resistin-induced inflammation. Proinflammatory properties of resistin were eva

Moraxella catarrhalis IgD-binding protein (MID) is a multimeric outer membrane protein belonging to the family of autotransporters. The IgD-binding domain of MID is located between amino acids MID 962-1200 and binds to amino acids 198-224 of the IgD C(H)1 region. In the present study, we describe a method to purify IgD from serum with high levels of IgD using a two-step affinity chromatography pro

This paper presents a summary analysis of data regarding evacuation model users experiences and needs obtained via an online survey. The survey was available in 6 languages: English, German, Chinese, Spanish, Italian and Russian. The different versions allowed the survey to be accessible to an international participant base. The survey was developed by the team at www.Evacmod.net ; an evacuation m

Innovation is an interactive learning process that is facilitated naturally by geographic proximity. Innovation intermediaries can serve as an extra catalyst to and facilitator of interaction and collaboration. With today’s more globalized knowledge and innovation landscape, companies and research organizations seek complementary competencies and partners with whom they can collaborate on a much b

Den ryska invasionen av Ukraina har orsakat ofattbart mänskligt lidande och har destabiliserat den europeiska säkerhetsordningen. I gengäld har världsledare och internationella organisationer krävt att den ryska aggressionen beivras. Den rättsvetenskapliga debatten om lämpliga åtgärder för att säkerställa straffrättsligt ansvar för aggressionsbrottet har emellertid uppvisat stor oenighet bland forThe Russian invasion of Ukraine has brought immense suffering to the Ukrainian people and has destabilised the European security order. In response, world leaders and international organisations have called for the prosecution of the Russian aggression. However, the scholarly debate on the appropriate measures to ensure criminal accountability for the crime of aggression has demonstrated widesprea

After the end of the Cultural Revolution, restrictions on art production in China eased considerably, and alternative accounts of life under Mao emerged, conflicting earlier official accounts of life in Maoist China. Since then, a number of films depicting the so-called decade of turmoil and the years preceding it have been produced. This essay studies and compares two Chinese films: Hibiscus Town

Artikel 1(1) i FN-stadgan ger uttryck för FN:s grundläggande syfte, att bevara den internationella fred- och säkerheten. Vidare föreskriver artikel 2(4) FN-stadgan att alla medlemsstater ska avhålla sig från bruk av, eller hot om, mellanstatligt våld. Dessa regleringar kompletteras av att stater enligt folkrätten tilldelas en omfattande suveränitet. Som utgångspunkt är stater således förbjudna attArticle 1(1) of the Charter of the United Nations states the main purpose of the United Nations, which is to maintain international peace and security. To achieve the purposes laid out in the Charter all states shall, according to article 2(4) of the Charter, refrain from the threat or use of force against the territorial integrity or political independence of any state, or in any other manner inc

The Swedish metropolitan politics have had the bottom-up perspective as a major principle to evolve the democratic participation in segregated areas. My objective was to investigate if a bottom-up perspective has been used as a method of evaluation in a sample of 10 evaluation reports made about democratic participation in Malmö. The key questions were; In the evaluations: - How was the bottom-u

The main purpose of this thesis is to study the impact of a number of independent variables on the cross-section of expected returns on NYSE, ALTERNEXT (formed AMEX) and NASDAQ stocks between 1990 and 2008 in the American market. The analysis is based on methods presented in a number of scientific articles, which will be dealt with below. This study starts with the formation of portfolios by pre-r

To provide retrospective, descriptive information on patients with cervical necrotizing fasciitis treated at a single center during the years 1998-2014, and to evaluate the outcome of a newly introduced treatment strategy. Retrospective analysis of clinical data obtained from medical records. Mortality, pre-morbidity, severity of illness, primary site of infection, type of bacteria, time parameter

Today's dynamic invariant detectors often produce invariants that are inconsistent with program semantics or programmer knowledge. We improve the consistency of dynamically discovered invariants by considering second-order constraints. These constraints encode knowledge about invariants, even when the invariants themselves are unknown. For instance, even though the invariants describing the behavi

We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. Of the seven SR proteins analyzed here, SRSF1, SRSF3, and SRSF9 induced HPV16 late gene expression, and five of the SR proteins affected HPV16 L1 mRNA splicing. Of the 15 hnRNP proteins analyzed here, hn

Carefully selecting the right collection datastructure can significantly improve the performance of a Java program. Unfortunately, the performance impact of a certain collection selection can be hard to estimate.To assist developers there are tools that recommend collections to use based on static and/or dynamic information about a program. The majority of existing collection selection tools for J

Juvenile idiopathic arthritis (JIA) is a heterogenous inflammatory joint disease and the most commonrheumatic disease in children. Oligoarticular JIA (oJIA) is the major subgroup, which mainly affects fewand large joints, such as the knee. The immunological processes and key players driving inflammationwithin the affected joints are not well characterised. Research has primarily focused on adaptiv

Besides friction and wear, airborne particle emission has become a central parameter when evaluating disc brake performance due to its potential adverse health effects as component of ambient air pollution. The pad friction material of brake system is composed of a mixture of ingredients grouped into four material categories: abrasives, reinforcing fibres, lubricants, and fillers. Some other ingre

Syftet med gällande studie var att, baserat på den dualistiska modellen för passion (DMP), undersöka huruvida harmonisk och tvångsmässig passion utgör två olika subkonstrukt, samt undersöka förhållandet mellan passion, prestationsbaserad självkänsla, behovstillfredsställelse och meningsfullhet i livet. Data samlades in genom självskattningsformulär och de statistiska analyserna utgick från 157 delThe purpose of the current study was to investigate, on the basis of the dualistic model of passion (DMP), whether harmonious (HP) and obsessive passion (OP) constitute two different sub-constructs, as well as investigate the relationship between passion, performance-based self-esteem, need satisfaction and meaningfulness in life. Data was collected through self-assessment forms and the statistica

Purpose – This article aims to examine how the agile approach interrelates with project complexity in product development. Design/methodology/approach – The study adopts a case study approach, using multiple dimensions of project complexity as an analytical framework to examine two complementary product development projects that involved the agile approach. Findings – The findings reveal that the