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The adipokine resistin is suggested to be an important link between obesity and insulin resistance. In the present study, we assessed the impact of resistin as inflammatogenic cytokine in the setting of arthritis. In vitro experiments on human PBMC were performed to assess cytokine response and transcription pathways of resistin-induced inflammation. Proinflammatory properties of resistin were eva

Moraxella catarrhalis IgD-binding protein (MID) is a multimeric outer membrane protein belonging to the family of autotransporters. The IgD-binding domain of MID is located between amino acids MID 962-1200 and binds to amino acids 198-224 of the IgD C(H)1 region. In the present study, we describe a method to purify IgD from serum with high levels of IgD using a two-step affinity chromatography pro

IL-8 is a major human neutrophil chemoattractant at mucosal infection sites. This study examined the C-X-C chemokine response to mucosal infection, and, specifically, the role of macrophage inflammatory protein (MIP)-2, one of the mouse IL-8 equivalents, for neutrophil-epithelial interactions. Following intravesical Escherichia coli infection, several C-X-C chemokines were secreted into the urine,

The thesis comprises four independent research papers and a summary that focus on two related dimensions. The first dimension focuses on the understanding of the production of health. Particularly, the question is asked whether community's stock of social capital influence individual's health. The second dimension focuses on an attempt to understand the causes of socioeconomic health inequality (S

Popular Abstract in Swedish Strategiska allianser utgör en tillväxtstrategi som har blivit ett allt vanligare inslag i näringslivet. Även forskningsbidragen kring strategiska allianser har vuxit i omfattning. Dessa forskningsbidrag har i stor utsträckning utgått från ett ekonomiskt/rationellt perspektiv samt fokuserat på de inledande faserna i samarbetet, med inriktning på motiv och val av samarbeThe purpose of this thesis is to develop an increased understanding of strategic alliance processes. A specific aim has been to explore the trust processes involved, and to better understand the dynamics of the strategic alliance processes. The study includes socio-cultural elements and captures both the manager´s and the employee´s perspectives in everyday life. The theoretical discussions were b

Sediment successions in coastal cliffs around Mezen Bay, southeastern White Sea, record an unusually detailed history of former glaciations, interstadial marine and fluvial events from the Weichselian. A regional glaciation model for the Weichselian is based on new data from the Mezen Bay area and previously published data from adjacent areas. Following the Mikulinian (Eemian) interglacial a shelf

As the number of new enteroviruses and human parechoviruses seems ever growing, the necessity for updated diagnostics is relevant. We have updated an enterovirus assay and combined it with a previously published assay for human parechovirus resulting in a multiplex one-step RT-PCR assay. The multiplex assay was validated by analysing the sensitivity and specificity of the assay compared to the res

The abundant serine proteinase inhibitor heparin cofactor II (HCII) has been proposed to inhibit extravascular thrombin. However, the exact physiological role of this plasma protein remains enigmatic. In this study, we demonstrate a previously unknown role for HCII in host defense. Proteolytic cleavage of the molecule induced a conformational change, thereby inducing endotoxin-binding and antimicr

Functional analysis of quantitative expression data is becoming common practice within the proteomics and transcriptomics fields; however, a gold standard for this type of analysis has yet not emerged. To grasp the systemic changes in biological systems, efficient and robust methods are needed for data analysis following expression regulation experiments. We discuss several conceptual and practica

Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart from these surfaces also neutrophil extracellular traps (NETs) provide a surface tha

A software breast phantom, based upon a breast tissue model derived from physical properties of breast anatomy, has been developed for mammography simulation. Synthetic mammograms, obtained by applying a breast compression model and an x-ray acquisition model to the software breast phantom, were compared by quantitative and qualitative means with real mammograms at different scales. Good agreement

Primary headaches are one of the most common conditions; migraine being most prevalent. Recent work on the pathophysiology of migraine suggests a mismatch in the communication or tuning of the trigeminovascular system, leading to sensitization and the release of calcitonin gene-related peptide (CGRP). In the current Opinion, we use the up-to-date molecular understanding of mechanisms behind migrai

Today's dynamic invariant detectors often produce invariants that are inconsistent with program semantics or programmer knowledge. We improve the consistency of dynamically discovered invariants by considering second-order constraints. These constraints encode knowledge about invariants, even when the invariants themselves are unknown. For instance, even though the invariants describing the behavi

We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. Of the seven SR proteins analyzed here, SRSF1, SRSF3, and SRSF9 induced HPV16 late gene expression, and five of the SR proteins affected HPV16 L1 mRNA splicing. Of the 15 hnRNP proteins analyzed here, hn

Purpose: To explore school-aged children's experiences about their best interests and participation in care during a hospital admission. Design and methods: A descriptive qualitative design involving in-depth, iterative inductive review of child responses to generate key words that led to identification of categories and themes. The study was guided by the United Nations Convention on the Rights o

Using examples from fieldwork among armed groups in Congo and pre-1989 Romania, this article argues against the prevailing ethos of ethnographers engagement with the people they study, in favor of a dynamic between engagement and detachment, what we call 'emotional management'. Two examples from our fieldwork are given, Hedlund on fieldwork with armed groups, Sampson on his informants being haraas