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Sepsis and invasive bacterial infection is a major cause of human disease and death worldwide. Streptococcus pyogenes is one of the major pathogens responsible for bacterial infections, which range from mild to severe and life threatening conditions. S. pyogenes contains a cell wall anchored M protein, which is an important virulence factor that can interact with many cells of the immune system. O
In this thesis, human behavior in rail tunnel fires is explored. Descriptive knowledge is presented related to the evacuation of passenger trains, and the subsequent tunnel evacuation to a safe location. More specifically, a theoretical framework that can aid the understanding of human behavior is identified, and its applicability to rail tunnels is demonstrated. In addition, new empirical data on
We have investigated the possibility of using the 2.45 GHz ISM band for communication between binaural hearing aids. The small size of a modern hearing aid makes it necessary to miniaturize the antennas to make this feasible. Two different types of hearing aid placements have been investigated: in the outer ear and in the ear canal. Both put strict demands on the size of the antenna, which have be
Background: Derivatized celluloses, such as methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC), are of pharmaceutical importance and extensively employed in tablet matrices. Each batch of derivatized cellulose is thoroughly characterized before utilized in tablet formulations as batch-to-batch differences can affect drug release. The substitution pattern of the derivatized cellulose pol
Aims The aims were to (i) investigate initial construct validity of a tool for assessment of time allocation in occupational balance, and (ii) describe perceived occupational balance and its relationship with socio-demographics, well-being, and personal recovery among people with mental illness. Methods Satisfaction with Daily Occupations and Occupational Balance (SDO-OB) was administered to 226 p
The aim of this study was to examine the effects of speech rate on children's performance on a widely used language comprehension test, the Test for Reception of Grammar, version 2 (TROG'2), and to explore how test performance interacts with task difficulty and with the child's working memory capacity. Participants were 102 typically-developing Swedish-speaking children randomly assigned to one of
Despite an abundance of peptides inside a cell, only a small fraction is ultimately presented by HLA-I on the cell surface. The presented peptides have HLA-I allomorph-specific motifs and are restricted in length. So far, detailed length studies have been limited to few allomorphs. Peptide-HLA-I (pHLA-I) complexes of different allomorphs are qualitatively and quantitatively influenced by tapasin t
Mixtures of two cationic proteins were used to prepare protein-DNA gel particles, employing associative phase separation and interfacial diffusion (Moran et al., 2009a). By mixing the two proteins, we have obtained particles that displayed higher loading efficiency and loading capacity values than those obtained in single-protein systems. However, nothing is known about the adverse effects on haem
Complement components and their cascade of reactions are important defense mechanisms within both innate and adaptive immunity. Many complement deficient patients still remain undiagnosed because of a lack of high throughput screening tools. Aiming towards neonatal proteome screening for immunodeficiencies, we used a multiplex profiling approach with antibody bead arrays to measure 9 complement pr
Purpose of this paper The purpose of this article is to explore themes and challenges in making logistics environmentally sustainable with a complexity theoretical perspective. Design/methodology/approach The research is explorative and based on a cross-sectional design focusing on different entities of supply chains. The study set out with a systematic review and content analysis of articles in
There is currently an imbalance with regards to the way that risks are treated in construction projects. Risks associated with structural failures as well as construction safety risks are often in focus while building performance risks (e.g. related to moisture or energy performance) receive less attention. These types of risks often disproportionately affect the end users/owners and can in many c
Objective: Exclusively breastfed infants with unrecognised cholestatic jaundice are at high risk of a vitamin K deficiency (VKD) bleeding. It is presently unknown whether (the size of) this risk depends on the degree of cholestasis. Since alpha-1-antitrypsin deficiency (A1AD) induces a variable degree of cholestasis, we assessed the risk of VKD bleeding in infants with cholestatic jaundice due to
Evidence of a possible association of cutaneous human papillomavirus (HPV) types, especially members of the genus Betapapillomavirus, and the development of non-melanoma skin cancer (NMSC) is accumulating. Vaccination with virus-like particles (VLPs) consisting of self-assembled L1, the major capsid protein, has been introduced to control anogenital HPV infection. This study examined the serologic
The thesis represents an instrumental case study exploring the planning and development process of the Norra Sorgenfri neighbourhood in Malmö, Sweden in relation to its envisioned and attested spatial and social inclusivity. The thesis aims to trace the existing dynamics of a growth-equity conflict in the planning and development process of Norra Sorgenfri in relation to the Sustainable Developmen
Emerging fine-grained cloud resource billing creates incentives to review the software execution footprint in virtual environments. Operators can use novel virtual execution environments with ever lower overhead: from virtual machines to containers, to unikernels and serverless functions. However, the execution footprint of security mechanisms in virtualized deployments has either remained the sam
OBJECTIVE: Spontaneous motility of the human oviduct is an important factor in the regulation of fertility that can be influenced by a variety of substances. In this study we examined the effects of several antiepileptic drugs on spontaneous contractions of isolated human oviducts.METHODS: The isolated ampullar and isthmic segments of Fallopian tubes, taken from 34 patients with extensive uterine
