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The objective of this study was to determine the prevalence and some predictors for vaccine and non-vaccine types of HPV infections among bivalent HPV vaccinated and non-vaccinated young women in Uganda. This was a comparative cross sectional study 5.5 years after a bivalent HPV 16/18 vaccination (Cervarix®, GlaxoSmithKline, Belgium) pilot project in western Uganda. Cervical swabs were collected b
Annually laminated sediments of Lake Woserin in north-eastern Germany are investigated using sedimentological and palynological methods. They facilitate high-resolution reconstruction of environmental and land-use change during ca. 7000–4000 cal. BP. Between 6100 and 5800 cal. BP, changes in woodland composition and structure are evident which coincide with a change in subsistence strategy, that i
Popular Abstract in Swedish Diabetes är en folksjukdom som kännetecknas av förhöjt blodsocker. Sjukdomens förekomst ökar dramatiskt över hela världen och beskrivs ofta som en pandemi. I huvudsak finns det två olika former av diabetes, typ 1 och typ 2. Typ 1 drabbar oftast barn och ungdomar – de insulinproducerande β-cellerna förstörs av kroppens egna immunförsvar. Vid typ 2 diabetes ser sjukdomsbiDefective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. T2D research has in recent years invested tremendous efforts in identifying new risk variants for the disease. It has proven t
The function of the efflux pump P-glycoprotein (Pgp) and ABCB1 single nucleotide polymorphisms (SNPs) should be considered as important tools to deepen knowledge of drug nephrotoxicity and disposition mechanisms. The aim of this study is to investigate the association of C3435T, G2677T, C1236T, and T129C ABCB1 SNPs with Pgp activity and exposure to different immunosuppressive drugs in renal transp
A method for the quantitative determination of non-steroidal anti-inflammatory drugs (NSAIDs) in sewage sludge was developed and validated. The target compounds were extracted using pressurized hot water extraction (PHWE) and then purified and preconcentrated by three-phase hollow fiber liquid phase microextraction (HF-LPME) followed by LC-ESI-MS analysis. The PHWE was optimized with regard to the
Background: Familial adenomatous polyposis (FAP) is typically characterized by multiple colonic polyps and frequent extracolonic features. Whereas the number of colonic polyps has been linked to the APC gene mutation, possible genotype-phenotype correlations largely remain to be defined for the extracolonic manifestations. Methods: Full genomic sequencing combined with multiplex ligation-dependent
PHENIX has measured the e(+)e(-) pair continuum in root s(NN) = 200 GeV Au+Au and p+p collisions over a wide range of mass and transverse momenta. The e(+)e(-) yield is compared to the expectations from hadronic sources, based on PHENIX measurements. In the intermediate-mass region, between the masses of the phi and the J/psi meson, the yield is consistent with expectations from correlated c (c) o
Background: We have previously reported that expression of the RNA-and DNA-binding protein RBM3 is associated with a good prognosis in breast cancer and ovarian cancer. In this study, the prognostic value of immunohistochemical RBM3 expression was assessed in incident cases of malignant melanoma from a prospective population-based cohort study. Methods: Until Dec 31(st) 2008, 264 incident cases of
Purpose Hip dislocation after arthroplasty for femoral neck fractures (FNF) remains a serious complication. The aim of our study was to investigate FNF patients treated with THA, with a special focus of comparing the effect of surgical approach and femoral head size on the risk of revision for dislocation. Methods Data were derived from the Lithuanian Arthroplasty Register, and we calculated the c
This paper investigates a time interval within the Late Ludfordian (Late Silurian), involving changes in faunal composition (the Lau Event), a major positive carbon isotope excursion (CIE), and contemporaneous sea-level changes in remote palaeo-basins. Based on the Silurian strata of Gotland (Sweden), we integrate sequence stratigraphy, carbon isotope stratigraphy, and platform-scale palaeoecologi
The inclusive top quark pair (t (t) over tilde) production cross-section sigma(t (t) over bar) has been measured in proton-proton collisions at root s = 7 TeV and root s = 8 TeV with the ATLAS experiment at the LHC, using t (t) over bar events with an opposite-charge e mu pair in the final state. The measurement was performed with the 2011 7 TeV dataset corresponding to an integrated luminosity of
A search for the Standard Model Higgs boson in the H -> WW(*()) -> lvlv (l = e.mu) decay mode is presented. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 4.7 fb(-1) at a centre-of-mass energy of 7 TeV collected during 2011 with the ATLAS detector at the Large Hadron Collider. No significant excess of events over the expected background is o
The human Sushi Domain-Containing Protein 4 (SUSD4) was recently shown to function as a novel inhibitor of the complement system, but its role in tumor progression is unknown.
BACKGROUND: Changes in glycosylation of serum proteins are common, and various glycoforms are being explored as biomarkers in cancer and inflammation. We recently showed that glycoforms detected by endogenous galectins not only provide potential biomarkers, but also have different functions when they encounter galectins in tissue cells. Now we have explored the use of a combination of two galectin
Family caregivers in palliative care have a need for knowledge and support from health professionals, resulting in the need for educational and supportive interventions. However, research has mainly focused on the experiences of family caregivers taking part in interventions. To gain an increased understanding of complex interventions, it is necessary to integrate the perspectives of health profes
Background: To investigate hand bone loss (HBL) measured by digital X-ray radiogrammetry (DXR) in patients with early rheumatoid arthritis (RA) receiving different treatment regimens, and to evaluate if DXR change rates during the first 12 months correlate with radiological damage after 24 months. Methods: From the total SWEFOT trial population, 159 patients had hand radiographs correctly timed an
The Dalitz decay eta -> e(+) e(-) gamma has been measured in the gamma p -> eta p reaction with the Crystal Ball and TAPS multiphoton spectrometers, together with the photon-tagging facility at the Mainz Microtron MAMI. The experimental statistic used in this work is one order of magnitude greater than in any previous measurement of eta -> e(+) e(-) gamma. The value obtained for the slope paramete
