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PURPOSE To compare the effect of therapy with anastrozole versus a combination of fulvestrant and anastrozole in women in first relapse of endocrine-responsive breast cancer. PATIENTS AND METHODS Postmenopausal women, or premenopausal women receiving a gonadotropin-releasing hormone agonist, with estrogen receptor- and/or progesterone receptor-positive disease at first relapse after primary trea

There are increasing reports of deaths and serious complications associated with the use of negative pressure wound therapy (NPWT). Bleeding may occur in patients when NPWT is applied to a wound with exposed blood vessels or vascular grafts, possibly due to mechanical deformation and hypoperfusion of the vessel walls. Recent evidence suggests that using a rigid barrier disc to protect underlying t

BACKGROUND: A previous study of healthy subjects showed that intake of 6 g cinnamon with rice pudding reduced postprandial blood glucose and the gastric emptying rate (GER) without affecting satiety. OBJECTIVE: The objective was to study the effect of 1 and 3 g cinnamon on GER, postprandial blood glucose, plasma concentrations of insulin and incretin hormones [glucose-dependent insulinotropic poly

Components derived from cartilage have been suggested to maintain the inflammation in joints in arthritis. Small leucine-rich repeat proteins (SLRPs) are structural components of cartilage important in organizing the meshwork of extracellular matrix components. It has recently been shown that the SLRP fibromodulin interacts with complement initiator C1q, leading to complement activation. The compl

Trees growing at their altitudinal or latitudinal distribution in Fennoscandia have been widelyused to reconstruct warm season temperatures, and the region hosts some of the world’slongest tree-ring chronologies. These multi-millennial long chronologies have mainly beenbuilt from tree remains found in lakes (subfossil wood from lake-shore trees). We used aunique dataset of Scots pine tree-ring dat

Haemophilus influenzae type b (Hib) is, in contrast to non-b H. influenzae, associated with severe invasive disease such as meningitis and epiglottitis in small children. To date accurate H. influenzae capsule typing requires PCR, a time-consuming and cumbersome method. MALDI-TOF MS provides rapid bacterial diagnostics and is increasingly used in clinical microbiology laboratories. Here MALDI-TOF

The ABBI (Audio Bracelet for Blind Interaction) device is designed for visually impaired and blind children to wear on the wrist and produce sound based on the movement of the arm through space. The primary func- tion is to inform a child (or adult) about his/her own movements to aid spatial cognition rehabilitation. How- ever, the device could also be worn by friends and family and be used to inf

It has been proposed that the EU Ecodesign Directive can promote resource efficiency through relevant ecodesign requirements. This paper examines the potential for rare earth element (REE) resource efficiency improvements in the event the current regulation for electric motors under the Ecodesign Directive is to be extended to comprise REE-based permanent magnet motors. The research is based on li

Viewing information systems (IS) as services is beneficial but still an unexplored approach for IS in organizations. The aim of this exercise is to contribute to the knowledge base on designing IS as services. This paper presents an analysis of enterprise resource planning (ERPs) systems through the lens of service oriented architecture (SOA). Services are explained and defined through SOA theory.

Popular Abstract in French L'inquiétude grandit quant à la perte de la biodiversité liée aux changements d'utilisation des terres, l’effet de cette perte sur les services écosystémiques fournis par les communautés naturelles et semi-naturelles et, finalement, la menace que cela pourrait entraîner sur le bien-être de l’Homme. Ce travail de thèse examine l'impact de l'utilisation des terres présenteConcerns are increasing about the loss of biodiversity under land use change and how this will affect the ecosystem services provided by natural and semi-natural communities and consequently how this will threaten human well-being. The thesis examines the impact of present and past land use on different aspects of biodiversity; namely species diversity, traits and functional diversity and on ecos

Popular Abstract in Swedish I många organisationer och företag har vi idag allt äldre medarbetare. Detta kommer troligen att bli ett bekymmer en bit in på 2000-talet, då medarbetare och chefer blir allt äldre eller går i pension. Rekryteringen av nya medarbetare innebär att man får in unga människor, som ofta är mer välutbildade och som har andra värderingar och attityder till arbete och styrning.Research has indicated that there is a growing tendency for young, well-educated people to hold different values toward work and management of work than previous generations. Thus managerial difficulties can arise when these different generations collaborate at work. In order to survive organisations and companies need a managerial leadership that knows how the younger workers view leadership, how

The most pronounced effects of FSH signaling are potentially displayed in follicle fluid (FF), which acts as a reservoir for FSH induced granulosa cell (GC) secreted hormones. This study investigates the effects of two common polymorphisms of FSHR, FSHR 307 (rs6165) and FSHR 680 (rs6166), by evaluating the hormone and gene expression profiles of human small antral follicles collected under physiol